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Histological improvement after anti-viral treatment for chronic hepatitis B virus infection.

Author: BrookM G, McDonaldJ A, PetrovicL, ScheuerP J, ThomasH C

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A study of 66 patients with chronic hepatitis B virus infection found that successful treatment with interferon or adenine arabinoside 5'-monophosphate was associated with the loss of both serum and hepatic markers of viral replication and a reduction in liver inflammation. This may prevent progression to cirrhosis.
Paper Details　
Original Abstract of the Article :
Sequential liver biopsies were taken from 66 patients with chronic hepatitis B virus (HBV) infection being followed in randomised controlled trials of therapy with alpha interferons or adenine arabinoside 5'-monophosphate. In the group of 23 patients responding to treatment with the permanent loss o...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://doi.org/10.1016/0168-8278(89)90010-x

データ提供：米国国立医学図書館（NLM）

Antiviral Treatment for Chronic Hepatitis B

Chronic hepatitis B virus (HBV) infection presents a formidable challenge for researchers, as the virus can persist in the liver for years, leading to inflammation and even cirrhosis. This study focuses on the impact of antiviral treatment on liver health. It examines liver biopsies taken from patients with chronic HBV infection who received antiviral therapy with alpha interferons or adenine arabinoside 5'-monophosphate. The research found that those patients who responded to treatment by eliminating HBe antigen and HBV-DNA from their blood showed a significant reduction in liver inflammation. In contrast, inflammation continued in those who did not respond to therapy, and even progressed to cirrhosis in some cases. The research further confirms that successful treatment of chronic HBV infection is associated with the loss of both serum and liver markers of HBV replication, highlighting the potential of antiviral therapy to prevent the progression to cirrhosis.

Fighting the Virus, Healing the Liver

The findings of this study, like a cool oasis in a scorching desert, provide hope for patients with chronic HBV infection. This study demonstrates the effectiveness of antiviral therapy in reducing liver inflammation and preventing the progression of the disease.

Protecting Liver Health

This research emphasizes the importance of early and effective antiviral treatment for chronic HBV infection to prevent liver damage.

Dr.Camel's Conclusion

The results of this study have significant implications for the treatment of chronic HBV infection.

Date :
  1. Date Completed 1989-06-19
  2. Date Revised 2019-08-17
Further Info :

Pubmed ID

2469711

DOI: Digital Object Identifier

10.1016/0168-8278(89)90010-x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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