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Neutrophil depletion suppresses pulmonary vascular hyperpermeability and occurrence of pulmonary edema caused by hantavirus infection in C.B-17 SCID mice.

Author: AmadaTakako, ArikawaJiro, HasegawaHideki, KomaTakaaki, NagataNoriyo, NishioSanae, SatoYuko, ShimizuKenta, YasudaShumpei P, YoshimatsuKumiko

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Neutrophils play a key role in the development of pulmonary edema after Hantaan virus infection in SCID mice by contributing to increased vascular permeability.
Paper Details　
Original Abstract of the Article :
Hantavirus infections are characterized by vascular hyperpermeability and neutrophilia. However, the pathogenesis of this disease is poorly understood. Here, we demonstrate for the first time that pulmonary vascular permeability is increased by Hantaan virus infection and results in the development ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054411/

データ提供：米国国立医学図書館（NLM）

Unveiling the Role of Neutrophils in Hantavirus-Induced Pulmonary Edema

This study explores the complexities of hantavirus infection, a serious illness that can lead to pulmonary edema. It's like investigating the delicate balance of a desert ecosystem, where even the smallest changes can have significant consequences.

The researchers are investigating the role of neutrophils, a type of white blood cell, in the development of pulmonary edema during hantavirus infection. They are seeking to understand the mechanisms behind this dangerous complication, much like desert archaeologists uncovering the secrets of ancient civilizations.

This research offers crucial insights into the pathogenesis of hantavirus infection, providing valuable information for developing potential treatments and prevention strategies. It's like discovering a hidden oasis of knowledge, offering a path to understanding and combating this threat.

Neutrophils: A Key Player in Hantavirus-Induced Pulmonary Edema

The study suggests that neutrophils play a significant role in the development of pulmonary edema during hantavirus infection. This is like discovering a critical link in a complex desert ecosystem, where a single species can have a major impact on the entire system.

Protecting Against Hantavirus Infection: A Multifaceted Approach

This research underscores the importance of understanding the complex mechanisms behind infectious diseases to develop effective treatment and prevention strategies. It's like carefully studying the desert landscape to identify the most vulnerable areas and develop strategies for mitigating risks.

Dr. Camel's Conclusion

This research highlights the importance of ongoing research into the complex mechanisms of infectious diseases. It provides crucial insights into the role of neutrophils in hantavirus infection, paving the way for new approaches to treatment and prevention.

Date :
  1. Date Completed 2015-01-20
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

24719427

DOI: Digital Object Identifier

PMC4054411

Related Literature

Article Analysis
・Effective treatment of hantavirus infections
SNS
PICO Info
in preparation
Languages

English

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