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Systematic review: The use of thiopurines or anti-TNF in post-operative Crohn's disease maintenance--progress and prospects.

Author: ArnottI D, JonesG R, KennedyN A, LeesC W, SatsangiJ

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Crohn's disease can recur after surgery, with recurrence rates as high as 77% within two years. Treatment with thiopurines or infliximab can reduce recurrence rates, but variations exist in effectiveness.
Paper Details　
Original Abstract of the Article :
Post-operative recurrence of Crohn's disease is an important management challenge, with 2-year recurrence rates defined by clinical, endoscopic and radiological parameters of up to 77%, 64% and 49%. Clinical and severe endoscopic recurrence vary widely in controlled trials from 13% to 36% and 22% to...See full text at original site
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引用元：
https://doi.org/10.1111/apt.12743

データ提供：米国国立医学図書館（NLM）

Post-Operative Crohn's Disease: Navigating the Shifting Sands of Recurrence

Crohn's disease, a chronic inflammatory bowel disease, can be a challenging condition to manage, particularly after surgery. This systematic review delves into the use of thiopurines and anti-TNF therapies in maintaining remission after surgery for Crohn's disease. The authors examine the effectiveness of these treatments in preventing disease recurrence and discuss the potential benefits and drawbacks of each approach.

A Compass for Post-Operative Crohn's: Guiding Treatment Decisions

The authors provide a comprehensive overview of the current evidence on thiopurines and anti-TNF therapies for post-operative Crohn's disease maintenance. This review is a valuable resource for clinicians navigating treatment decisions, offering insights into the effectiveness and potential side effects of these different therapies. It is a beacon of knowledge in the desert of Crohn's disease management.

The Desert of Crohn's Disease: Navigating the Landscape of Recurrence

This research highlights the challenges of managing post-operative Crohn's disease, emphasizing the need for effective treatment strategies to prevent disease recurrence. The authors' review of the available evidence provides valuable insights into the potential benefits and limitations of different treatment approaches, guiding clinicians in making informed decisions for their patients. This research is a crucial step towards improving the management of this complex and often debilitating disease.

Dr. Camel's Conclusion

Post-operative Crohn's disease can be a challenging journey for patients and clinicians alike. This systematic review provides a valuable compass for navigating the complex landscape of treatment options. By understanding the effectiveness and potential risks of thiopurines and anti-TNF therapies, clinicians can make informed decisions to optimize patient care and minimize disease recurrence.

Date :
  1. Date Completed 2014-09-22
  2. Date Revised 2022-01-29
Further Info :

Pubmed ID

24738574

DOI: Digital Object Identifier

10.1111/apt.12743

SNS
PICO Info
in preparation
Languages

English

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