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Efficacy of multi-functional liposomes containing daunorubicin and emetine for treatment of acute myeloid leukaemia.
Author: BarrattGillian, DøskelandStein Ove, HerfindalLars, MyhrenLene, NicolasValérie, NilssenIda Mostrøm
Original Abstract of the Article :
Despite recent advances in chemotherapy against acute myeloid leukaemia (AML), the disease still has high mortality, particularly for patients who tolerate extensive chemotherapy poorly. Nano-formulations have potential to minimise the adverse effects of chemotherapy. We present here a liposomal for...See full text at original site
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引用元:
https://doi.org/10.1016/j.ejpb.2014.04.002
データ提供:米国国立医学図書館(NLM)
A Multifunctional Liposomal Approach for Acute Myeloid Leukemia
Acute myeloid leukemia (AML) is a serious blood cancer, like a relentless desert sandstorm that can quickly overwhelm the body. This study investigates a novel liposomal formulation for treating AML, combining two chemotherapy drugs, daunorubicin (DNR) and emetine (Eme), within a single liposome. The liposome's surface was modified with folate to target AML cells, enhancing drug delivery and improving the drugs' cytotoxic activity. The researchers also explored the effect of methotrexate (MTX) on drug delivery and efficacy.
Targeted Therapy for AML
This research offers a promising new approach to treating AML. The liposomal formulation, designed to target AML cells, delivers a potent combination of chemotherapy drugs directly to the cancer cells, minimizing damage to healthy cells. This is like a desert nomad using a well-aimed arrow to target a specific threat, ensuring minimal collateral damage. The study also demonstrates that the liposomes' efficacy is enhanced by pre-treating AML cells with MTX, further increasing drug delivery and cytotoxic activity.
Hope for AML Patients
This innovative liposomal formulation holds significant potential for treating AML. It offers a more targeted and effective approach to chemotherapy, potentially reducing the severe side effects associated with traditional treatments. Imagine a future where AML patients experience better outcomes and quality of life, much like a desert oasis offering respite and rejuvenation to weary travelers. This research is a step in that direction.
Dr. Camel's Conclusion
This study offers a promising new weapon in the fight against AML. By utilizing liposomal technology to target chemotherapy drugs directly to cancer cells, this research holds the potential to improve treatment outcomes and reduce side effects for AML patients. This approach is like a skilled desert nomad using a well-aimed arrow to neutralize a dangerous threat, ensuring a more targeted and effective intervention.
Date :
- Date Completed 2015-07-03
- Date Revised 2018-12-02
Further Info :
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