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Kaempferol attenuates the glutamate-induced oxidative stress in mouse-derived hippocampal neuronal HT22 cells.

Author: JunMira, KimGeum-Soog, SongKyung-Sik, YangEun-Ju

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the neuroprotective effects of kaempferol (KF) isolated from butterbur on glutamate-induced oxidative stress in hippocampal neuronal cells. KF significantly increased cell viability and reduced glutamate-induced calcium influx and reactive oxygen species generation. This suggests KF may be a potential therapeutic candidate for neurodegenerative diseases like Alzheimer's disease.
Paper Details　
Original Abstract of the Article :
It is thought that the neuronal cell loss caused by oxidative stress is the primary mechanism underlying the pathogenesis of several neurodegenerative disorders. Glutamate is an endogenous neurotransmitter, but at high concentrations it can act as a neurotoxicant by increasing the intracellular leve...See full text at original site
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引用元：
https://doi.org/10.1039/c4fo00068d

データ提供：米国国立医学図書館（NLM）

Kaempferol: A Hidden Oasis in the Desert of Neurodegenerative Diseases

This study explores the potential benefits of kaempferol, a natural compound found in various plants, in protecting against glutamate-induced oxidative stress in neuronal cells. Researchers are like explorers searching for natural remedies that can combat the debilitating effects of neurodegenerative diseases. This research investigates the neuroprotective effects of kaempferol in hippocampal neuronal cells.

Kaempferol: A Potential Shield Against Neuronal Damage

The study's findings suggest that kaempferol may offer a promising neuroprotective effect, potentially mitigating the damage caused by glutamate-induced oxidative stress in neuronal cells. This discovery is like finding a hidden oasis in the desert, providing a potential source of hope and protection against the devastating effects of neurodegenerative diseases.

Finding Strength in the Desert of Brain Health

This study underscores the importance of exploring natural compounds, like kaempferol, as potential therapeutic agents for neurodegenerative diseases. It highlights the need for further research to understand the mechanisms of action and potential benefits of kaempferol in protecting against neuronal damage.

Dr.Camel's Conclusion

This study provides a glimmer of hope in the fight against neurodegenerative diseases, suggesting that kaempferol may offer a potential neuroprotective effect against glutamate-induced oxidative stress in neuronal cells. The research highlights the importance of exploring natural compounds as potential therapeutic agents and encourages further investigation into the mechanisms of action and potential benefits of kaempferol. Just as a camel navigates a challenging desert landscape, we must continue to seek out new and innovative approaches to combat the devastating effects of neurodegenerative diseases.

Date :
  1. Date Completed 2015-02-23
  2. Date Revised 2023-12-13
Further Info :

Pubmed ID

24770605

DOI: Digital Object Identifier

10.1039/c4fo00068d

Related Literature

Article Analysis
・Effective treatment of butterbur
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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