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D-penicillamine-induced granulomatous hepatitis in brown Norway rats.
Author: MetushiImir G, UetrechtJack, ZhuXu
Original Abstract of the Article :
The mechanism of idiosyncratic drug reactions (IDRs) remains poorly understood. D-penicillamine treatment is associated with a wide range of autoimmune reactions including liver injury. An animal model which utilizes brown Norway (BN) rats has been used to investigate the mechanism of D-penicillamin...See full text at original site
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引用元:
https://doi.org/10.1007/s11010-014-2065-8
データ提供:米国国立医学図書館(NLM)
D-penicillamine-Induced Granulomatous Hepatitis: Navigating the Desert of Idiosyncratic Drug Reactions
Imagine a vast and complex desert, where the intricate balance of the immune system can be disrupted by unexpected interactions with medications. Idiosyncratic drug reactions (IDRs) are unpredictable responses to drugs that occur in a small percentage of individuals. This study explores the mechanisms underlying D-penicillamine-induced granulomatous hepatitis, a rare but potentially serious liver injury. The research, conducted in an animal model, provides insights into the immunological processes that contribute to this condition. It's like uncovering a hidden oasis in the desert of IDR research, providing a deeper understanding of these complex and often baffling reactions.
The Desert of Idiosyncratic Drug Reactions: Understanding the Complexities of D-penicillamine
The study sheds light on the mechanisms underlying D-penicillamine-induced granulomatous hepatitis, revealing the role of specific immunological processes in triggering this condition. This understanding is crucial for developing strategies to prevent or manage these adverse reactions, ensuring the safety of patients taking D-penicillamine. It's like finding a way to navigate the treacherous paths within the desert of IDR research, paving the way for safer and more effective drug treatments.
Navigating the Desert of Drug Reactions: Seeking Safer Treatments
Idiosyncratic drug reactions (IDRs) can be unpredictable and potentially dangerous. Continued research into the mechanisms underlying these reactions is essential for developing safer and more effective drug treatments. It's like exploring the vast desert of drug reactions, seeking to identify the hidden dangers and create more secure pathways for patient care.
Dr.Camel's Conclusion
This study provides valuable insights into the mechanisms underlying D-penicillamine-induced granulomatous hepatitis. It's like finding a hidden oasis in the desert of idiosyncratic drug reactions, offering a path to better understand and manage these complex and potentially dangerous events.
Date :
- Date Completed 2015-02-12
- Date Revised 2021-10-21
Further Info :
Related Literature
English
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