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Dopamine transporter genotype and stimulant dose-response in youth with attention-deficit/hyperactivity disorder.

Author: BishopJeffrey, CookEdwin H, KittlesRick, NewcornJeffrey, SteinMark A, WaldmanIrwin

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Children with attention-deficit/hyperactivity disorder (ADHD) and the 9/9 genotype may require higher stimulant doses to achieve adequate symptom control.
Paper Details　
Original Abstract of the Article :
OBJECTIVES: This study seeks to determine if variation in the dopamine transporter gene (SLC6A3/DAT1) moderates the dose-response effects of long-acting dexmethylphenidate (D-MPH) and mixed amphetamine salts (MAS) in children with attention-deficit/hyperactivity disorder (ADHD). METHODS: Fifty-six ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064733/

データ提供：米国国立医学図書館（NLM）

Unlocking the Secrets of ADHD Treatment: The Dopamine Transporter's Role

The realm of [psychiatry] is continually seeking to refine [treatment strategies] for [attention-deficit/hyperactivity disorder (ADHD)]. This study delves into the genetic underpinnings of [ADHD] and explores the relationship between [dopamine transporter genotype] and the effectiveness of [stimulant medication]. The authors investigate the [dose-response effects] of [long-acting dexmethylphenidate (D-MPH)] and [mixed amphetamine salts (MAS)], uncovering a significant connection between [genotype] and [treatment outcomes].

Individualized Treatment: A Tailored Approach to ADHD

The authors' findings provide valuable insights into the [individualized nature of ADHD treatment]. Their research demonstrates that [genetic variations] can influence [drug response] and highlight the importance of considering [individualized treatment plans] based on [genotype]. This discovery underscores the need for a more personalized approach to [ADHD] management.

A New Horizon for ADHD Treatment: The Promise of Precision Medicine

This study offers a glimpse into the future of [ADHD] treatment. The authors' exploration of [genotype-specific drug response] paves the way for [precision medicine] approaches tailored to the unique needs of each patient. By incorporating [genetic testing] into [clinical practice], we can optimize treatment outcomes and enhance the quality of life for individuals with [ADHD].

Dr. Camel's Conclusion

Just like a camel adapts to its environment by seeking out the most suitable water source, individuals with [ADHD] require personalized treatment approaches. This research highlights the importance of considering [genetic factors] in tailoring treatment plans. By embracing this individualized approach, we can create a more effective and compassionate path to recovery for those living with [ADHD].

Date :
  1. Date Completed 2015-02-07
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

24813374

DOI: Digital Object Identifier

PMC4064733

Related Literature

Article Analysis
・Effects of dexmethylphenidate
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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