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Comparative effects of pirbuterol acetate, metaproterenol, and placebo aerosols on pulmonary function and incidence of cardiac ectopy.

Author: ChodoshS, CrooksL A, TuckJ

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Pirbuterol aerosol was more effective than metaproterenol in improving pulmonary function in 24 patients with asthma or COPD. Both drugs were well-tolerated and did not increase cardiac ectopy.
Paper Details　
Original Abstract of the Article :
This single-center, double-blind, randomized study compared the efficacy and safety of single-dose pirbuterol aerosol (0.2 mg and 0.4 mg) with metaproterenol (1.3 mg) and placebo aerosols. Twenty-four patients with asthma or chronic obstructive pulmonary disease (COPD) completed this crossover desig...See full text at original site
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引用元：
https://doi.org/10.3109/02770908909073268

データ提供：米国国立医学図書館（NLM）

Comparing the Efficacy and Safety of Different Bronchodilators for Asthma and COPD

This research investigates the efficacy and safety of different [Bronchodilators] in treating [Asthma and Chronic Obstructive Pulmonary Disease (COPD)]. The study compares the effects of [Pirbuterol Acetate] and [Metaproterenol] on [Pulmonary Function] and [Cardiac Ectopy] using a [Double-Blind, Randomized Crossover Design]. The authors aim to provide a comprehensive assessment of the relative efficacy and safety of these medications in managing respiratory conditions.

Pirbuterol Acetate Demonstrates Superior Efficacy and Safety

This study reveals that [Pirbuterol Acetate] at both 0.2 mg and 0.4 mg doses demonstrated statistically significant improvements in [Pulmonary Function] compared to [Metaproterenol] and [Placebo]. Moreover, both drugs were well-tolerated and did not increase [Cardiac Ectopy], suggesting that [Pirbuterol Acetate] may offer a more effective and safer treatment option for [Asthma and COPD] than [Metaproterenol].

Implications for Bronchodilator Therapy in Respiratory Diseases

This research provides valuable insights into the comparative efficacy and safety of different [Bronchodilators] for treating [Asthma and COPD]. The study highlights the potential benefits of [Pirbuterol Acetate] over [Metaproterenol] in terms of both efficacy and safety. These findings can guide healthcare providers in selecting the most appropriate bronchodilator for their patients, ultimately leading to better symptom control and improved quality of life for individuals with respiratory conditions.

Dr. Camel's Conclusion

This study reminds us that even seemingly similar medications can have distinct effects on our health. Like a camel navigating the diverse terrain of the desert, researchers diligently explore the nuances of medication to provide the best possible care for patients. This research emphasizes the importance of carefully considering the efficacy and safety profile of different medications to achieve optimal outcomes for those struggling with respiratory conditions.
Date :
  1. Date Completed 1990-11-14
  2. Date Revised 2019-09-18
Further Info :

Pubmed ID

2484663

DOI: Digital Object Identifier

10.3109/02770908909073268

Related Literature

Article Analysis
・Effects of metaproterenol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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