Effects of metaproterenol: A Synthesis of Findings from 14 Studies

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Original Abstract of the Article

Major Research Findings

Metaproterenol is a β2-adrenergic agonist used to treat respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD). These research papers examine the bronchodilator effects, cardiovascular effects, and metabolic effects of metaproterenol.

Metaproterenol shows bronchodilator effects, as reported in 10 , , 4 , , 8 , 14 , 13 , , 3 , 12 , 6 , 7 , 5 , 9 , . The effectiveness may differ depending on the method of administration, either inhalation or oral. 8 It has also been found that metaproterenol can have cardiovascular effects, such as increased heart rate and blood pressure. , , 11 , 13 , 12 , , , 1 , 2 Administering metaproterenol may increase blood glucose, lactate, free fatty acids, insulin, and glucagon levels. 11 , 13 , 1 Side effects such as tremors, palpitations, anxiety, and headaches may occur with metaproterenol. 10 , 8 , 13 However, metaproterenol is generally considered a safe drug. 10 , 12 .

Benefits and Risks

Benefits Summary

Metaproterenol is effective in relieving symptoms of respiratory diseases such as asthma and COPD. It alleviates symptoms such as shortness of breath and wheezing by widening the airways.

Risks Summary

Side effects of metaproterenol include tremors, palpitations, anxiety, and headaches. Metaproterenol can also increase heart rate and blood pressure. Furthermore, metabolic effects such as increased blood sugar levels and decreased blood potassium levels have been reported.

Comparison between Studies

Similarities between Studies

These studies show that metaproterenol has bronchodilator effects. They also show that metaproterenol can affect the cardiovascular and metabolic systems.

Differences between Studies

These studies indicate that the effects and side effects of metaproterenol, and the effectiveness may vary depending on the method of administration. For example, inhalation tends to have a faster onset of effect compared to oral administration. Also, the side effects of metaproterenol vary depending on individual susceptibility.

Consistency and Contradictions in Results

These studies suggest that metaproterenol is an effective drug for treating respiratory diseases. However, the effects and side effects of metaproterenol may vary from person to person, so caution is needed.

Practical Applications and Cautions

It is important to use metaproterenol according to your doctor’s instructions. Do not take it without consulting a doctor or change the dosage yourself. If you experience any side effects while using metaproterenol, consult your doctor immediately.

Limitations of Current Research

These studies were conducted on specific populations, so their applicability to other populations is unclear. Additionally, these studies did not investigate the long-term effects of metaproterenol.

Future Research Directions

Further research is needed on the long-term effects of metaproterenol, its effects in various populations, and its interactions with other medications. Research is also needed to reduce the side effects of metaproterenol.

Conclusion

Metaproterenol is an effective drug for treating respiratory diseases such as asthma and COPD. However, metaproterenol can cause side effects, so it is important to use it according to your doctor’s instructions. Further research is needed on metaproterenol.

Literature analysis of 14 papers
Positive Content
13
Neutral Content
0
Negative Content
1
Article Type
5
0
0
0
14
1.

Metabolic effects of metaproterenol overdose: hypokalemia, hyperglycemia and hyperlactatemia.

Author: BarnewoltB A, WalterF G, BeyT A

Hyperglycemia
Hyperlactatemia
Hypokalemia
Metaproterenol toxicity

Metaproterenol toxicity can present with a combination of hypokalemia, hyperglycemia, and hyperlactatemia, a triad similar to theophylline poisoning. This highlights the importance of considering both theophylline and beta-agonist toxicity in patients with this metabolic profile, as their treatments are distinct.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

3.

A comparison of the effects of ipratropium bromide and metaproterenol sulfate in acute exacerbations of COPD.

Author: KarpelJ P, PesinJ, GreenbergD, GentryE

Effective for COPD exacerbations
Decline in blood oxygenation

Both ipratropium bromide and metaproterenol sulfate are effective medications for acute exacerbations of chronic obstructive pulmonary disease when administered via a metered dose inhaler. However, ipratropium may be safer as it did not cause a decline in blood oxygenation.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Effects of inhaled metaproterenol and atropine on the pulmonary mechanics of infants with bronchopulmonary dysplasia.

Author: KaoL C, DurandD J, NickersonB G

Airway resistance improvement
Expiratory flow improvement
None reported

Inhaled metaproterenol and atropine both improve pulmonary function in infants with bronchopulmonary dysplasia. In a randomized, double-blind study of 15 infants, both drugs significantly improved airway resistance and maximal expiratory flow at functional residual capacity. There were no significant differences between the effects of the two drugs, and no synergy was observed when they were combined.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Comparative effects of pirbuterol acetate, metaproterenol, and placebo aerosols on pulmonary function and incidence of cardiac ectopy.

Author: ChodoshS, CrooksL A, TuckJ

Improves lung function
Treats asthma
None reported

Pirbuterol aerosol was more effective than metaproterenol in improving pulmonary function in 24 patients with asthma or COPD. Both drugs were well-tolerated and did not increase cardiac ectopy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Dose-related effects of nebulized metaproterenol in asthmatic children.

Author: CrainE F, GershelJ C, KadarA, KastnerT

Effective bronchodilation
Side effects

Inhaled metaproterenol solution (5%) was effective in treating acute bronchospasm in asthmatic children aged 6-12. The study found that a dose of 0.1 ml (5 mg) provided as much bronchodilation as higher doses but with fewer side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Bronchodilator and side effects of different modes of administration of metaproterenol: inhaled, oral, and in combination.

Author: MaguireG P, EmirgilC

Bronchodilation
Increased heart rate
Palpitation
Systolic blood pressure
Tremor

Inhaled and oral metaproterenol were compared in 20 patients with asthma. The combination of inhaled and oral metaproterenol resulted in greater bronchodilation than either route alone. Inhaled metaproterenol had no significant side effects, while oral metaproterenol was associated with a small increase in pulse rate and blood pressure and unpleasant sensations such as tremor and palpitation.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Acute effects of aerosolized metaproterenol on breathing pattern of patients with symptomatic bronchial asthma.

Author: TobinM J, BirchS, JenouriG, SacknerM A

Bronchodilation
Improved breathing

Metaproterenol improved FEV1.0 in patients with symptomatic bronchial asthma, but did not alter respiratory center drive, suggesting that the mechanism underlying heightened respiratory drive does not wholly depend on bronchoconstriction.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

10.

Comparison of the acute cardiopulmonary effects of oral albuterol, metaproterenol, and terbutaline in asthmatics.

Author: WolfeJ D, YamateM, BiedermannA A, ChuT J

Bronchodilation
Long duration of action
Central nervous system side effects
Musculoskeletal side effects

Oral albuterol and terbutaline were found to be more effective and longer-acting bronchodilators than oral metaproterenol. Albuterol was associated with fewer side effects. The more rapid onset of action of metaproterenol suggests that it may be advantageous for as-needed use.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

11.

Comparative metabolic and cardiovascular effects of carbuterol, isoproterenol, metaproterenol and salbutamol in the baboon.

Author: PotterD E, WoodsonL C, KempenR R, EllisS

Bronchodilation
Cardiovascular effects

Isoproterenol was more effective than selective beta-adrenergic drugs in elevating metabolic substrates and increasing heart rate and respiratory rate. Selective beta-adrenergic drugs also produced significant changes at higher doses.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

12.

Acute bronchial and cardiovascular effects of oral pirbuterol and metaproterenol.

Author: EnceT J, TashkinD P, HoD, ChildJ S

Beta 2-adrenergic specificity
Effective bronchodilator
Long duration of action
Low toxicity
Mild side effects

Pirbuterol, an orally active beta 2-selective sympathomimetic agent, provided a longer duration of bronchodilatation than metaproterenol in 24 asthmatic patients, without significant cardiovascular effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

13.

Metabolic and cardiovascular effects of carbuterol and metaproterenol.

Author: SandersJ P, PotterD E, EllisS, BeeD E, GrantJ A

Bronchodilation
Side effects

Carbuterol, a selective beta-adrenergic bronchodilator, was well tolerated at a dose of 2 mg in 8 patients with asthma. The higher dose (4 mg) was associated with more frequent side effects, including increases in glucose, insulin, lactate, and free fatty acids. Metaproterenol also caused increases in glucose and insulin.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

14.

Long-term effects of metaproterenol in asthmatic children.

Author: SacknerM A, SilvaG, ZuckerC, MarksM B

Effective for asthma
Long-acting
No tolerance

Oral metaproterenol was administered to asthmatic children for 3 months. No chronic tolerance developed to the drug. The bronchodilating effect of metaproterenol lasted at least 5 hours.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

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