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Pharmacogenetics of second-generation antipsychotics.

Author: BrennanMark D

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This review examines pharmacogenetics of 'second-generation' antipsychotics, emphasizing replicated findings for polymorphisms and comparing them with larger-scale studies. Variants in pharmacokinetic, pharmacodynamic, and pharmacotypic genes are discussed, with CYP2D6 metabolizer phenotype showing clinical significance for dosing, and pharmacotypic genes emerging as potential biomarkers for drug response and side effects.
Paper Details　
Original Abstract of the Article :
This review considers pharmacogenetics of the so called 'second-generation' antipsychotics. Findings for polymorphisms replicating in more than one study are emphasized and compared and contrasted with larger-scale candidate gene studies and genome-wide association study analyses. Variants in three ...See full text at original site
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引用元：
https://doi.org/10.2217/pgs.14.50

データ提供：米国国立医学図書館（NLM）

Pharmacogenetics of Second-Generation Antipsychotics: Mapping the Desert of Personalized Medicine

The world of mental health is complex, and finding the right treatment for each individual can be like navigating a vast and often confusing desert. This study delves into the field of pharmacogenetics, exploring the role of genetic variations in influencing the effectiveness and side effects of second-generation antipsychotics.

The researchers examine the potential role of genetic variations in influencing the metabolism, target engagement, and response to second-generation antipsychotics. The study highlights the potential of genetic testing to guide medication selection and optimize treatment outcomes for individuals with mental health disorders. The authors' findings suggest that pharmacogenetic testing could be a valuable tool for personalizing mental health care, ensuring that individuals receive the most appropriate treatment based on their unique genetic makeup.

A Personalized Approach: Mapping the Desert of Genetic Diversity

The study's findings underscore the importance of considering genetic factors when prescribing medications. The researchers' work highlights the potential of pharmacogenetic testing to guide medication selection and optimize treatment outcomes for individuals with mental health disorders.

A New Era in Mental Health Care: Finding Oasis in the Desert of Personalized Medicine

This study provides a glimpse into the future of mental health care, suggesting that pharmacogenetics could play a significant role in tailoring treatment approaches to individual needs. The authors' findings encourage further research into the potential of genetic testing to personalize mental health care, ensuring that individuals receive the most effective and safe treatment possible.

Dr. Camel's Conclusion

This research is a testament to the ongoing advancements in the field of personalized medicine. The study's findings highlight the potential of pharmacogenetic testing to optimize treatment outcomes for individuals with mental health disorders. The authors' work encourages us to continue exploring the vast and often hidden oases of knowledge within the human genome, seeking to unravel the secrets that will help us to personalize healthcare and improve the lives of all.

Date :
  1. Date Completed 2015-01-13
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

24897292

DOI: Digital Object Identifier

10.2217/pgs.14.50

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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