Effects of iloperidone: A Synthesis of Findings from 25 Studies

  1. Home
  2. Effects of iloperidone
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Effects of iloperidone: A Synthesis of Findings from 25 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Effects of iloperidone: A Synthesis of Findings from 25 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Key Research Findings

Iloperidone has emerged as a potentially effective treatment option for schizophrenia, particularly for patients experiencing inadequate response or poor tolerability to other antipsychotics like risperidone, olanzapine, or aripiprazole. A study comparing gradual and immediate switching to iloperidone from these agents found no significant differences in overall efficacy, as measured by the Integrated Clinical Global Impression of Change (I-CGI-C), at 12 weeks. This suggests that switching to iloperidone, regardless of the transition method, can effectively improve symptoms. 14 Additionally, research has highlighted the potential metabolic advantages of iloperidone. Compared to older second-generation antipsychotics like olanzapine or clozapine, iloperidone is associated with a lower risk of weight gain and metabolic abnormalities. 21 However, iloperidone, similar to other atypical antipsychotics, can induce prolactin elevation. While this effect is generally dose-dependent, it remains a potential concern, especially considering the comparable prolactin-elevating profile of iloperidone to drugs like clozapine. 12 Furthermore, iloperidone has been linked to cases of ejaculatory dysfunction, including retrograde ejaculation. This highlights the importance of considering potential sexual side effects when prescribing iloperidone. 6

Benefits and Risks

Benefit Summary

Iloperidone has demonstrated effectiveness in improving symptoms of schizophrenia. Additionally, it holds a potential advantage over some other atypical antipsychotics in terms of a lower risk of weight gain and metabolic complications. 21 Iloperidone can be a suitable option for switching patients from other antipsychotics. 14

Risk Summary

Iloperidone can lead to elevated prolactin levels, which may require monitoring. It may also cause sexual side effects, such as retrograde ejaculation. 12 6 Similar to other antipsychotics, iloperidone can cause side effects like dizziness, dry mouth, somnolence, and weight increase. 14

Study Comparison

Commonalities

Studies consistently show iloperidone to be effective in improving schizophrenia symptoms. Moreover, research consistently indicates a lower risk of weight gain and metabolic abnormalities compared to other atypical antipsychotics. However, the evidence regarding prolactin elevation and sexual side effects is more variable across different studies.

Differences

The extent of prolactin elevation and the occurrence of sexual side effects associated with iloperidone have shown inconsistencies across different studies. Some research suggests a higher risk of prolactin elevation, while others show a lower risk. Similarly, some studies have documented cases of ejaculatory dysfunction, while others have not reported this side effect. These differences could be attributed to factors such as study design variations, patient populations, and other methodological considerations.

Consistency and Contradictions

While iloperidone demonstrates consistent efficacy in improving schizophrenia symptoms, research findings regarding its prolactin-elevating potential and sexual side effects display some inconsistencies. Further investigation is warranted to clarify these aspects and provide a more comprehensive understanding of iloperidone's effects.

Practical Implications

Iloperidone serves as a therapeutic option for schizophrenia. Its potential for prolactin elevation and sexual side effects should be considered, and regular monitoring may be needed. As with all antipsychotics, individuals should be aware of potential side effects like dizziness, dry mouth, somnolence, and weight increase. It is crucial to strictly adhere to medical guidance and report any adverse effects promptly.

Current Research Limitations

Iloperidone is a relatively new drug, and the available data on its long-term safety and effectiveness is limited. Additional research is necessary to enhance our understanding of its long-term effects.

Future Research Directions

Further research is needed to investigate the long-term safety and effectiveness of iloperidone. Additional studies are also needed to understand the mechanisms behind its potential prolactin elevation and sexual side effects, and to explore ways to mitigate these risks. Comparative studies examining iloperidone alongside other antipsychotics will also provide valuable insights.

Conclusion

Iloperidone is a promising treatment option for schizophrenia, offering potential benefits in symptom improvement and a reduced risk of metabolic complications. However, potential side effects, particularly concerning prolactin and sexual function, should be carefully considered. Remember to follow your doctor's instructions and report any side effects promptly. Continued research is essential to expand our knowledge of iloperidone's safety, efficacy, and optimal use in treating schizophrenia.

Literature analysis of 25 papers
Positive Content
23
Neutral Content
1
Negative Content
1
Article Type
1
3
3
10
24
2.

Fast quantification of ten psychotropic drugs and metabolites in human plasma by ultra-high performance liquid chromatography tandem mass spectrometry for therapeutic drug monitoring.

Author: AnsermotNicolas, Brawand-AmeyMarlyse, KottelatAstrid, EapChin B

Psychotropic drug quantification

This study developed a sensitive and fast method to measure the levels of 10 psychotropic drugs and their metabolites in human plasma. The method uses ultra-high performance liquid chromatography coupled with tandem mass spectrometry. It was fully validated to ensure accurate and reliable measurements, making it suitable for therapeutic drug monitoring and pharmacokinetic studies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Validation StudyResearch to assess the validity and reliability of new measurement methods or diagnostic tests.

Language : English

3.

An Open Trial of Iloperidone for Mixed Episodes in Bipolar Disorder.

Author: SinghVivek, ArnoldJodi Gonzalez, PrihodaThomas J, MartinezMelissa, BowdenCharles L

Mixed episode treatment
Adverse events

This study examined the tolerability and efficacy of iloperidone for bipolar disorder mixed episodes in a 5-month open-label trial. Mania and depression scores significantly improved over the course of the study for study completers. However, 39% of the eligible sample discontinued early because of adverse effects, most commonly increased heart rate/palpitations and urinary incontinence/intense urge to urinate.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

4.

The effects of second generation antipsychotic drugs on sleep variables in healthy subjects and patients with schizophrenia.

Author: MontiJaime M, TorteroloPablo, Pandi PerumalSeithikurippu R

Ameliorate insomnia
SGAs for schizophrenia

Insomnia is a common feature in schizophrenia. Second-generation antipsychotics, including clozapine, olanzapine, and paliperidone, have shown promise in improving sleep quality in patients with schizophrenia. These medications may increase total sleep time, sleep efficiency, and slow-wave sleep, while reducing sleep latency.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

5.

Retrograde ejaculation associated with quetiapine and treatment with low-dose imipramine.

Author: RoughleyMatthew, LyallMarc

Quetiapine treatment
RE treatment
Sexual side-effects

This case report describes a 25-year-old man who developed retrograde ejaculation (RE) during treatment with quetiapine, a commonly used antipsychotic. RE improved with low-dose imipramine, suggesting a potential treatment option for antipsychotic-associated RE.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

Iloperidone-induced ejaculatory dysfunction: A case series.

Author: RavaniNiraj Narendra, KatkePramod H

Retrograde ejaculation

Iloperidone, a medication used to treat schizophrenia, can cause retrograde ejaculation, likely due to its effect on alpha 1-adrenergic receptors.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

7.

Body weight and metabolic adverse effects of asenapine, iloperidone, lurasidone and paliperidone in the treatment of schizophrenia and bipolar disorder: a systematic review and exploratory meta-analysis.

Author: De HertMarc, YuWeiping, DetrauxJohan, SweersKim, van WinkelRuud, CorrellChristoph U

Improved adverse effect burden
Tolerability benefits
Metabolic dysregulations

This review compares the metabolic risks associated with newer second-generation antipsychotics (SGAs) - asenapine, iloperidone, lurasidone, and paliperidone - to those of older SGAs, such as olanzapine and clozapine. While SGAs offer improved tolerability compared to first-generation antipsychotics (FGAs), they can still cause metabolic problems, particularly in patients without prior exposure to antipsychotics, those with first episodes of illness, and children and adolescents.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

8.

Effects of iloperidone, combined with desipramine, on alcohol drinking in the Syrian golden hamster.

Author: KhokharJibran Y, GreenAlan I

Alcohol use disorder
Desipramine
Iloperidone

This study investigated the potential of iloperidone, a safer clozapine-like antipsychotic, to reduce alcohol drinking in patients with schizophrenia. Results in a hamster model showed that iloperidone reduced alcohol drinking as effectively as clozapine, and the effect was enhanced when combined with desipramine.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

A review of the pharmacology, efficacy and tolerability of recently approved and upcoming oral antipsychotics: an evidence-based medicine approach.

Author: CitromeLeslie

Antipsychotic treatment
Akathisia
Extrapyramidal side effects
Metabolic abnormalities
QTc prolongation
Somnolence
Weight gain

Newly approved oral antipsychotics, including iloperidone, asenapine, and lurasidone, offer potential benefits over existing agents but differ in their side effect profiles. Lurasidone appears to minimize weight gain and metabolic abnormalities, while other agents have varying effects on QT interval, akathisia, and sedation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

11.

Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis.

Author: LeuchtStefan, CiprianiAndrea, SpineliLoukia, MavridisDimitris, OreyDeniz, RichterFranziska, SamaraMyrto, BarbuiCorrado, EngelRolf R, GeddesJohn R, KisslingWerner, StapfMarko Paul, LässigBettina, SalantiGeorgia, DavisJohn M

Schizophrenia treatment

This study aimed to integrate the available evidence to create hierarchies of the comparative efficacy, risk of all-cause discontinuation, and major side-effects of antipsychotic drugs for the treatment of schizophrenia.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

12.

The effects of novel and newly approved antipsychotics on serum prolactin levels: a comprehensive review.

Author: PeuskensJ, PaniL, DetrauxJ, De HertM

Hyperprolactinemia

Hyperprolactinemia (HPRL) is a common side effect of antipsychotic medications used to treat schizophrenia. While newer antipsychotics are generally associated with lower prolactin levels, all antipsychotics can still cause HPRL. This review summarizes the available evidence on the effects of different antipsychotics on prolactin levels.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

14.

A trial evaluating gradual- or immediate-switch strategies from risperidone, olanzapine, or aripiprazole to iloperidone in patients with schizophrenia.

Author: WeidenPeter J, CitromeLeslie, AlvaGus, BramsMatthew, GlickIra D, JacksonRichard, MattinglyGreg, KianifardFarid, MengXiangyi, PestreichLinda, HochfeldMarla, WinseckAdam

Schizophrenia treatment
Dizziness
Dry mouth
Somnolence
Weight increase

This 12-week randomized open-label trial compared the efficacy and tolerability of switching to iloperidone, a novel antipsychotic, gradually or immediately in patients with schizophrenia. Both methods showed similar improvements in overall efficacy and safety/tolerability outcomes at 12 weeks, indicating that the choice of switching method may not significantly impact clinical outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Novel Atypical Antipsychotics: Metabolism and Therapeutic Drug Monitoring (TDM).

Author: MandrioliRoberto, ProttiMichele, MercoliniLaura

Schizophrenia treatment
Pharmacokinetic interactions
Side effects

Ioperidone, asenapine, and lurasidone are new atypical antipsychotics with distinct metabolic characteristics. Therapeutic drug monitoring (TDM) can be valuable for personalizing and optimizing treatment with these drugs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

17.

Asenapine, iloperidone and lurasidone: critical appraisal of the most recently approved pharmacotherapies for schizophrenia in adults.

Author: BoboWilliam V

Schizophrenia treatment
Weight gain reduction

Ioperidone, asenapine, and lurasidone are new atypical antipsychotics that are similar in efficacy and have a low propensity for weight gain or adverse changes in glycemic or lipid profile.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

19.

A Systematic Review of Atypical Antipsychotics in Chronic Pain Management: Olanzapine Demonstrates Potential in Central Sensitization, Fibromyalgia, and Headache/Migraine.

Author: JimenezXavier F, SundararajanTharani, CovingtonEdward C

Fibromyalgia relief
Headache relief
Pain relief
Extrapyramidal symptoms
Metabolic side effects
Weight gain

Olanzapine shows preliminary and consistent efficacy in fibromyalgia and headache/migraine, but more robust studies are needed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

21.

Clinical pharmacology of atypical antipsychotics: an update.

Author: MauriM C, PalettaS, MaffiniM, ColasantiA, DragognaF, Di PaceC, AltamuraA C

Antipsychotic treatment
Weight management

This review summarizes the clinical pharmacology and pharmacodynamic data related to atypical antipsychotics, including clozapine, risperidone, paliperidone, olanzapine, quetiapine, amisulpride, ziprasidone, aripiprazole, asenapine, iloperidone, lurasidone and cariprazine. It also provides a summary of their acute pharmacokinetic properties. Four new second-generation antipsychotics are available: iloperidone, asenapine, lurasidone and in the next future cariprazine. These new agents are advisable for the lower propensity to give weight gain and metabolic abnormalities compared with older second-generation antipsychotics. Lurasidone seems to be best in terms of minimizing unwanted alterations in body weight and metabolic variables. Therapeutic drug monitoring is not strictly necessary for all of the new antipsychotic drugs because there are no unequivocal data supporting a relationship between plasma drug levels and clinical outcomes or side effects. The exception can be represented by clozapine for which plasma levels of 350-420 ng/ml are reported to be associated with an increased probability of a good clinical response. Also for olanzapine an established therapeutic range (20-50 ng/ml) is proposed to yield an optimal response and minimize side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

23.

Metabolic side-effects of the novel second-generation antipsychotic drugs asenapine and iloperidone: a comparison with olanzapine.

Author: BoydaHeidi N, ProcyshynRic M, PangCatherine C Y, HawkesErin, WongDaniel, JinChen Helen, HonerWilliam G, BarrAlasdair M

SGA efficacy
Metabolic side effects

Preclinical models were used to evaluate the metabolic side-effects of glucose intolerance and insulin resistance for the novel second-generation antipsychotics (SGAs) asenapine and iloperidone, with olanzapine as a comparator.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

24.

Therapeutic drug monitoring of common antipsychotics.

Author: PatteetLisbeth, MorrensManuel, MaudensKristof E, NiemegeersPeter, SabbeBernard, NeelsHugo

Individualized therapy
Therapeutic drug monitoring
Antipsychotic side effects
Treatment failure

This review provides information for interpreting outcome results from monitoring antipsychotics in biological samples. It covers the working mechanisms, pharmacological effects, drug interactions, and analytical methods of classical and atypical antipsychotics.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.