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Antibody induction versus placebo, no induction, or another type of antibody induction for liver transplant recipients.

Author: ChanAn-Wen, GluudChristian, PenningaLuit, SteinbrüchelDaniel A, WettergrenAndré, WilsonColin H

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

T-cell specific antibody induction seems to reduce acute rejection when compared with no induction. No other clear benefits or harms were associated with the use of any kind of T-cell specific antibody induction compared with no induction, or when compared with another type of T-cell specific antibody.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Liver transplantation is an established treatment option for end-stage liver failure. To date, no consensus has been reached on the use of immunosuppressive T-cell antibody induction for preventing rejection after liver transplantation. OBJECTIVES: To assess the benefits and harms of im...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8925015/

データ提供：米国国立医学図書館（NLM）

Liver Transplantation: A Quest for Effective Immunosuppression

Liver transplantation is a life-saving procedure for individuals with end-stage liver failure. This research examines the use of immunosuppressive T-cell antibody induction in preventing rejection after liver transplantation. The authors systematically review the evidence for various antibody induction strategies, comparing their benefits and risks in a comprehensive meta-analysis. Their findings provide valuable insights for clinicians seeking to optimize immunosuppression protocols for liver transplant recipients.

Immunosuppressive Antibody Induction: Balancing Benefits and Risks

This research provides a nuanced overview of the use of immunosuppressive T-cell antibody induction in liver transplantation. The authors' meta-analysis suggests that while T-cell antibody induction may reduce the risk of acute rejection, it does not appear to have a significant impact on other important outcomes such as mortality, graft loss, or adverse events. Their findings underscore the need for careful consideration of the benefits and risks of antibody induction in individual patients.

A Balancing Act: Navigating Immunosuppression in Liver Transplantation

Imagine a camel traversing a desert, carefully navigating the shifting sands to reach its destination. This research explores the complexities of immunosuppression in liver transplantation, emphasizing the need for a balanced approach that considers both the benefits and risks of different treatment strategies. By understanding the evidence for various antibody induction protocols, clinicians can make informed decisions that optimize patient care and minimize the potential for adverse outcomes.

Dr.Camel's Conclusion

This research provides a valuable review of the evidence for immunosuppressive T-cell antibody induction in liver transplantation. While antibody induction may reduce the risk of acute rejection, it does not appear to have a significant impact on other important outcomes. The authors highlight the need for careful consideration of the benefits and risks of antibody induction in individual patients to ensure optimal care.
Date :
  1. Date Completed 2015-10-02
  2. Date Revised 2023-10-11
Further Info :

Pubmed ID

24901467

DOI: Digital Object Identifier

PMC8925015

Related Literature

Article Analysis
・Effective treatment of liver transplantation
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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