Effective treatment of liver transplantation: A Synthesis of Findings from 34 Studies

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Original Abstract of the Article

Major Research Findings

Liver transplantation has become a widely accepted treatment for various end-stage liver diseases, including hepatocellular carcinoma (HCC), and is often considered the best option. However, the shortage of donor organs poses a significant challenge for this life-saving procedure. 1

In the case of HCC, repeat liver resection (RLR) is considered the first-line treatment for intrahepatic recurrence, while salvage liver transplantation (SLT) is seen as a second-line option. 22

Several studies have focused on improving liver transplantation techniques. One notable example is the "no-touch" technique, which has shown promise in improving survival rates for patients with advanced HCC. 31

A significant challenge in liver transplantation is the management of recurrent HCC after the procedure. While surgery is often the preferred approach, systemic treatments combining mTOR inhibitors with sorafenib are emerging as potential options. However, these treatments can have significant side effects. 14

Researchers are exploring alternative treatments for liver disease, including autologous stem cell therapy, which is being investigated as a potential alternative to liver transplantation due to the shortage of donor organs. 9

Treatment Summary

Liver transplantation is a surgical procedure that involves replacing a diseased liver with a healthy liver from a donor. It is considered the gold standard for end-stage liver disease and has demonstrated significant success rates. 1

For patients with HCC, the treatment options include surgical resection and liver transplantation. Liver transplantation is shown to have better long-term survival outcomes compared to resection, but it is associated with higher perioperative morbidity and mortality rates. However, the tumor-free survival rate is significantly higher with liver transplantation. 13

Salvage liver transplantation (SLT) is a treatment option for patients with recurrent HCC after initial hepatic resection. 8

The “no-touch” technique is a new technique for liver transplantation that aims to minimize trauma to the liver during the procedure. This technique has shown promise in improving survival rates for patients with advanced HCC. 31

After liver transplantation, immunosuppressive drugs are administered to prevent the rejection of the transplanted liver. There is ongoing research on reducing the dosage of glucocorticosteroids in immunosuppressive regimens, which could potentially reduce the risk of side effects such as diabetes and hypertension. 16

Benefits and Risks

Benefits Summary

Liver transplantation offers the potential for a cure for end-stage liver disease and HCC, providing a significant improvement in quality of life and survival rates. Liver transplantation can provide patients with a longer survival period and a better quality of life compared to other treatment options. 13

Risks Summary

Liver transplantation involves significant risks, including infection, rejection of the transplanted liver, bleeding, and death. 10 Additionally, long-term immunosuppression therapy after transplantation can lead to side effects like diabetes, hypertension, and increased susceptibility to infections. 16

Comparison Between Studies

Commonalities Among Studies

Many studies confirm that liver transplantation is an effective treatment for end-stage liver disease and HCC.

Differences Between Studies

There are differences in research findings regarding the optimal management of recurrent HCC following liver transplantation, as well as in the types and dosages of immunosuppressive drugs used.

Consistency and Contradictions in Results

The majority of research consistently indicates that liver transplantation is a viable and effective treatment for end-stage liver disease and HCC. However, inconsistencies exist regarding the most effective strategies for managing recurrent HCC and the optimal immunosuppressive regimens. Further research is needed to clarify these areas and provide more definitive guidance for treatment decisions.

Considerations for Real-World Application

Liver transplantation is a major surgical procedure with inherent risks, including infection, rejection, bleeding, and death. 10 Post-transplantation, patients must manage immunosuppressive medications, which carry their own risks like diabetes, hypertension, and increased risk of infections. 16 It is crucial for patients to have open discussions with their medical team to fully understand the benefits and risks associated with liver transplantation before making a decision.

Limitations of Current Research

Many studies on liver transplantation rely on retrospective data, which can be susceptible to biases. Additionally, numerous factors can influence patient outcomes after transplantation, making it challenging to draw definitive conclusions based on research findings.

Future Research Directions

Further research is needed to address key areas in liver transplantation, including the development of more effective methods for preventing recurrent HCC after transplantation. It is also essential to explore new techniques and therapies that can help alleviate the shortage of donor organs.

Conclusion

Liver transplantation is a powerful treatment option that can offer a cure for end-stage liver disease and HCC, providing patients with the potential for a longer lifespan and a better quality of life. However, it is crucial to remember that liver transplantation is a complex and high-risk procedure. It is important for patients to fully understand the risks and benefits before making a decision. Furthermore, ongoing research is vital for advancing liver transplantation techniques and therapies, ultimately improving outcomes for patients in need.

Treatment List

Liver transplantation, surgical resection, sorafenib, immunosuppressive drugs, glucocorticosteroids, hypothermic oxygenated machine perfusion (HOPE), Milan Criteria, repeat liver resection (RLR), salvage liver transplantation (SLT), “no-touch” technique, autologous stem cell therapy

Keywords
Benefit Keywords
Liver transplant success
1
Hepatocellular carcinoma treatment
2
Effective HCV treatment
Improved SVR
3
Liver transplant treatment
4
Improved survival
5
Liver transplant benefit
6
Improved survival
No increased mortality
7
Salvage liver transplantation
8
Liver disease treatment
9
LT for malignancies
10
Reduced cytomegalovirus infection
Reduced diabetes mellitus
11
Reduced acute rejection
Reduced cytomegalovirus infection
Reduced diabetes mellitus
12
Higher long-term survival
Higher tumor-free survival
13
HCC recurrence treatment
14
Increased survival
15
Reduced diabetes
Reduced hypertension
16
Improved organ allocation
Longer survival
18
Improved liver transplant outcomes
19
Reduced diabetes
Reduced hypertension
20
Liver transplant
Simvastatin protection
21
Improved HCC treatment
22
End-stage liver disease
Liver transplant
23
Liver transplantation management
24
LT for CRLM
25
Expanded donor pool
Reconditioned organs
26
Favorable outcomes
Improved pregnancy
27
APOLT for PALF
28
Treatment for NRCLM
29
Improved outcome
LT for malignancies
30
Improved survival
Reduced tumor growth
31
Improved outcomes
Reduced complications
32
CRLM treatment
33
Post-hepatectomy liver failure treatment
34
Risk Keywords
No consensus on criteria
Restrictive criteria
6
Recurrence
7
Hepatocellular carcinoma
8
Recurrence risk
10
Increased serum creatinine
12
Higher surgery-related morbidity
Higher surgery-related mortality
Lower 1-year survival
13
Recurrence risk
14
Severe side effects
15
Increased rejection
Renal impairment
16
Increased rejection
Renal impairment
20
Liver damage
21
Steatotic liver impact
23
Increased complications
Maternal and fetal risks
27
Liver graft shortage
33
Literature analysis of 34 papers
Positive Content
32
Neutral Content
1
Negative Content
1
Article Type
5
19
24
18
33
1.

Bile acids for liver-transplanted patients.

Author: ChenW, GluudC

Liver transplant success

This study investigates the potential role of bile acids in reducing allograft rejection after liver transplantation by modulating the expression of major histocompatibility complex class molecules.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

2.

Liver transplantation for hepatocellular carcinoma: University Hospital Essen experience and metaanalysis of prognostic factors.

Author: SotiropoulosGeorgios C, LangHauke, NadalinSilvio, NeuhäuserMarkus, MolmentiErnesto P, BabaHideo A, PaulAndreas, SanerFuat H, WeberFrank, HilgardPhilipp, FrillingAndrea, BroelschChristoph E, MalagóMassimo

Hepatocellular carcinoma treatment

This study aimed to correlate pathologic findings with outcomes after liver transplantation for hepatocellular carcinoma.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

3.

Clinical trial: peg-interferon alfa-2b and ribavirin for the treatment of genotype-1 hepatitis C recurrence after liver transplantation.

Author: LodatoF, BerardiS, GramenziA, MazzellaG, LenziM, MorelliM C, TameM R, PiscagliaF, AndreoneP, , BallardiniG, BernardiM, BianchiF B, BiselliM, BolondiL, CesconM, ColecchiaA, D'ErricoA, Del GaudioM, ErcolaniG, GraziG L, GrigioniW, LorenziniS, PinnaA D, RavaioliM, RodaE, SamaC, VivarelliM

Effective HCV treatment
Improved SVR

A study of 53 patients with hepatitis C virus recurrence after liver transplantation found that pegylated-interferon alfa-2b plus ribavirin was effective in 26% of patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Bile acids for liver-transplanted patients.

Author: PoropatGoran, GiljacaVanja, StimacDavor, GluudChristian

Liver transplant treatment

This article discusses the potential role of bile acids in decreasing allograft rejection after liver transplantation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

5.

Liver transplantation for hepatic metastases of neuroendocrine pancreatic tumors: a survival-based analysis.

Author: MáthéZoltan, TagkalosEvangelos, PaulAndreas, MolmentiErnesto P, KóboriLászló, FouzasIoannis, BeckebaumSusanne, SotiropoulosGeorgios C

Improved survival

Liver transplantation (LT) was a viable treatment option for pancreatic neuroendocrine tumors (NETs) with hepatic metastases. In a systematic review of 20 studies involving 89 patients, LT was associated with a 5-year survival rate of 44%. Age greater than or equal to 55 years and simultaneous LT-pancreatic resection were predictors of worse survival.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

6.

Criteria for liver transplantation for HCC: what should the limits be?

Author: SilvaMauricio F, ShermanMorris

Liver transplant benefit
No consensus on criteria
Restrictive criteria

This systematic review clarifies the debate surrounding liver transplantation for patients with hepatocellular carcinoma (HCC) whose tumors exceed the traditional Milan criteria. The review examines data for patients whose tumors exceed the criteria at presentation and those whose tumors are down-staged with treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

7.

Salvage liver transplantation in the treatment of hepatocellular carcinoma: a meta-analysis.

Author: LiHong-Yu, WeiYong-Gang, YanLv-Nan, LiBo

Improved survival
No increased mortality
Recurrence

Salvage liver transplantation (SLT) for the treatment of hepatocellular carcinoma (HCC) has similar long-term survival rates compared to primary liver transplantation (PLT) without increasing perioperative mortality.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

8.

Systematic review of efficacy and outcomes of salvage liver transplantation after primary hepatic resection for hepatocellular carcinoma.

Author: ChanDaniel L, AlzahraniNayef A, MorrisDavid L, ChuaTerence C

Salvage liver transplantation
Hepatocellular carcinoma

A liver transplant is the best treatment for people with liver cancer (HCC) and cirrhosis, but a shortage of donor organs means many patients have to wait, during which time their condition can worsen. This review examines the safety and effectiveness of liver transplantation as a second option for people with HCC who have had part of their liver removed and then had the cancer return.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

9.

Systematic review: the effects of autologous stem cell therapy for patients with liver disease.

Author: MooreJ K, StutchfieldB M, ForbesS J

Liver disease treatment

Liver disease is becoming more common and serious. While liver transplantation is a valuable option, it is expensive and requires lifelong medication to suppress the immune system, and there are not enough donor organs. Using a patient's own stem cells is being investigated as a potential treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

10.

Liver transplantation for hepatic tumors: a systematic review.

Author: RavaioliMatteo, ErcolaniGiorgio, NeriFlavia, CesconMatteo, StacchiniGiacomo, Del GaudioMassimo, CucchettiAlessandro, PinnaAntonio Daniele

LT for malignancies
Recurrence risk

Liver transplantation has become a more common and successful treatment, but the use of transplantation to treat liver cancer is still debated due to the high risk of the cancer returning. This review examines liver transplantation for various liver cancers, including hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA), liver metastases (LM), and other rare tumors. While liver transplantation is a promising option for selected patients with liver cancer, it's important to weigh the potential benefits against the limited availability of organs and the costs involved.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

11.

Antibody induction versus corticosteroid induction for liver transplant recipients.

Author: PenningaLuit, WettergrenAndré, WilsonColin H, ChanAn-Wen, SteinbrüchelDaniel A, GluudChristian

Reduced cytomegalovirus infection
Reduced diabetes mellitus

T-cell specific antibody induction seems to reduce diabetes mellitus and may reduce cytomegalovirus infection when compared with corticosteroid induction. No other clear benefits or harms were associated with the use of T-cell specific antibody induction compared with corticosteroid induction.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

12.

Antibody induction versus placebo, no induction, or another type of antibody induction for liver transplant recipients.

Author: PenningaLuit, WettergrenAndré, WilsonColin H, ChanAn-Wen, SteinbrüchelDaniel A, GluudChristian

Reduced acute rejection
Reduced cytomegalovirus infection
Reduced diabetes mellitus
Increased serum creatinine

T-cell specific antibody induction seems to reduce acute rejection when compared with no induction. No other clear benefits or harms were associated with the use of any kind of T-cell specific antibody induction compared with no induction, or when compared with another type of T-cell specific antibody.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

13.

Liver transplantation versus liver resection for hepatocellular carcinoma: a meta-analysis.

Author: XuXin-Sen, LiuChang, QuKai, SongYan-Zhou, ZhangPeng, ZhangYue-Lang

Higher long-term survival
Higher tumor-free survival
Higher surgery-related morbidity
Higher surgery-related mortality
Lower 1-year survival

LT achieved significantly higher rates of surgery-related morbidity and mortality, and the 1-year survival rate was lower in LT. However, the 3- and 5-year survival rates and tumor-free survival rate were significantly higher in LT.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

14.

Recurrence of hepatocellular carcinoma after liver transplantation: an update.

Author: MazzolaAlessandra, CostantinoAndrea, PettaSalvatore, BartolottaTommaso Vincenzo, RaineriMaurizio, SaccoRodolfo, BrancatelliGiuseppe, CammàCalogero, CabibboGiuseppe

HCC recurrence treatment
Recurrence risk

Liver transplantation is the only cure for some patients with hepatocellular carcinoma (HCC). This review examines the challenges of HCC recurrence after transplantation and explores the use of systemic treatments, such as combining an mTOR inhibitor with sorafenib.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

15.

Managements of recurrent hepatocellular carcinoma after liver transplantation: A systematic review.

Author: de'AngelisNicola, LandiFilippo, CarraMaria Clotilde, AzoulayDaniel

Increased survival
Severe side effects

This study reviewed the efficacy and safety of treatments for recurrent hepatocellular carcinoma in patients who had undergone liver transplantation. The study found that recurrence rates are high and overall survival is poor. The most effective treatments were surgical resection for localized recurrence and Sorafenib for systemic spread of the cancer.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

16.

Glucocorticosteroid-free versus glucocorticosteroid-containing immunosuppression for liver transplanted patients.

Author: FairfieldCameron, PenningaLuit, PowellJames, HarrisonEwen M, WigmoreStephen J

Reduced diabetes
Reduced hypertension
Increased rejection
Renal impairment

This Cochrane review assesses the benefits and harms of glucocorticosteroid avoidance or withdrawal versus glucocorticosteroid-containing immunosuppression following liver transplantation. There was no statistically significant difference in mortality, graft loss, or infection. Glucocorticosteroid avoidance or withdrawal appeared to reduce diabetes mellitus and hypertension but increased acute rejection, glucocorticosteroid-resistant rejection, and renal impairment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

17.

Liver transplantation for unresectable colorectal liver metastases: A systematic review.

Author: MorisDimitrios, TsilimigrasDiamantis I, ChakedisJeffery, BealEliza W, FelekourasEvangelos, VernadakisSpiridon, SchizasDimitrios, FungJohn J, PawlikTimothy M

This systematic review explored the efficacy, safety, and outcomes of liver transplantation (LT) for colorectal liver metastases (CLM) in countries with high organ supply, addressing the renewed interest in LT as a treatment option.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

18.

Resection or Transplant in Early Hepatocellular Carcinoma.

Author: SchoenbergMarkus B, BucherJulian N, VaterAdrian, BazhinAlexandr V, HaoJingcheng, GubaMarkus O, AngeleMartin K, WernerJens, RentschMarkus

Improved organ allocation
Longer survival

For patients with early hepatocellular carcinoma (HCC) and well-compensated cirrhosis, liver transplantation (LT) leads to longer survival than surgical liver resection (LR), as LT removes pre-cancerous tissue as well as the tumor.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

19.

Hypothermic oxygenated machine perfusion (HOPE) for orthotopic liver transplantation of human liver allografts from extended criteria donors (ECD) in donation after brain death (DBD): a prospective multicentre randomised controlled trial (HOPE ECD-DBD).

Author: CziganyZoltan, SchöningWenzel, UlmerTom Florian, BednarschJan, AmygdalosIakovos, CramerThorsten, RogiersXavier, PopescuIrinel, BoteaFlorin, FroněkJiří, KroyDaniela, KochAlexander, TackeFrank, TrautweinChristian, TolbaRene H, HeinMarc, KoekGer H, DejongCornelis H C, NeumannUlf Peter, LurjeGeorg

Improved liver transplant outcomes

Orthotopic liver transplantation (OLT) is the standard treatment for end-stage liver disease, and using extended criteria donor (ECD) liver allografts may improve access to donor organs. Hypothermic oxygenated machine perfusion (HOPE) shows promise for reconditioning poor quality ECD liver allografts.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

20.

Glucocorticosteroid-free versus glucocorticosteroid-containing immunosuppression for liver transplanted patients.

Author: FairfieldCameron, PenningaLuit, PowellJames, HarrisonEwen M, WigmoreStephen J

Reduced diabetes
Reduced hypertension
Increased rejection
Renal impairment

Glucocorticosteroid avoidance or withdrawal after liver transplantation may reduce diabetes and hypertension but increase acute rejection and renal impairment. More research is needed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

21.

The addition of simvastatin administration to cold storage solution of explanted whole liver grafts for facing ischemia/reperfusion injury in an area with a low rate of deceased donation: a monocentric randomized controlled double-blinded phase 2 study.

Author: PaganoDuilio, OlivaElisabetta, KhouzamSimone, TuzzolinoFabio, CintorinoDavide, Li PetriSergio, di FrancescoFabrizio, RicottaCalogero, BonsignorePasquale, TropeaAlessandro, CalamiaSergio, CostanzoFederico, LucaAngelo, GruttadauriaSalvatore

Liver transplant
Simvastatin protection
Liver damage

Liver transplantation is the best treatment for end-stage liver disease. The interruption of blood supply to the donor liver during cold storage can damage the liver, affecting its function after transplantation. This study aims to evaluate the benefits of treating the donor liver with Simvastatin compared to the standard transplant procedure.

Clinical Trial ProtocolA plan for conducting a clinical trial. It describes in detail the purpose, design, methodology, and statistical considerations of the trial, ensuring the transparency and consistency of the trial.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

22.

Comparison Between Salvage Liver Transplantation and Repeat Liver Resection for Recurrent Hepatocellular Carcinoma: A Systematic Review and Meta-analysis.

Author: KostakisI D, MachairasN, ProdromidouA, StamopoulosP, GaroufaliaZ, FouzasI, SotiropoulosG C

Improved HCC treatment

Salvage liver transplantation (SLT) and repeat liver resection (RLR) are compared as treatment options for hepatocellular carcinoma (HCC) recurrence.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

23.

The Impact of Steatosis on the Outcome of Liver Transplantation: A Meta-Analysis.

Author: ZhangQiong-Yue, ZhangQiong-Fang, ZhangDa-Zhi

End-stage liver disease
Liver transplant
Steatotic liver impact

This systematic review and meta-analysis found that steatotic livers can be used for liver transplantation, but the impact on outcome is still controversial.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

24.

Induction immunosuppression in adults undergoing liver transplantation: a network meta-analysis.

Author: BestLawrence Mj, LeungJeffrey, FreemanSuzanne C, SuttonAlex J, CooperNicola J, MilneElisabeth Jane, CowlinMaxine, PayneAnna, WalshawDana, ThorburnDouglas, PavlovChavdar S, DavidsonBrian R, TsochatzisEmmanuel, WilliamsNorman R, GurusamyKurinchi Selvan

Liver transplantation management

Liver transplantation is the best treatment for liver failure. After surgery, people need medication to prevent their body from rejecting the new liver. These medications are divided into those used in the first few months after surgery (induction immunosuppression) and those used long-term (maintenance immunosuppression). There's a lot of debate about whether the initial medications are necessary and which are best.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

25.

The role of liver transplantation for colorectal liver metastases: A systematic review and pooled analysis.

Author: GiannisDimitrios, SiderisGeorgios, KakosChristos D, KatsarosIoannis, ZiogasIoannis A

LT for CRLM

Liver transplantation (LT) is being considered more often as a treatment option for colorectal cancer that has spread to the liver and cannot be surgically removed. While early results were not promising, recent reports from countries with a good supply of donor organs suggest that LT may be a viable option for some patients with this type of cancer.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

26.

Ex vivo machine perfusion: current applications and future directions in liver transplantation.

Author: MichelottoJulian, GassnerJoseph M G V, MoosburnerSimon, MuthVanessa, PatelMadhukar S, SelznerMarkus, PratschkeJohann, SauerIgor M, RaschzokNathanael

Expanded donor pool
Reconditioned organs

This systematic review of prospective clinical studies on ex vivo liver machine perfusion found that the technique is safe and feasible in both standard and expanded criteria donors. Ex vivo liver machine perfusion seems to be a suitable strategy to expand the donor pool for liver transplantation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

27.

Pregnancy Outcomes After Liver Transplantation: A Systematic Review and Meta-Analysis.

Author: ValentinNelson, GuerridoIsabel, RozenshteynFrederick, PinottiRachel, WuYi Chia, CollinsKelsey, ShahMichelle, HershmanMelissa, WeisbergIlan

Favorable outcomes
Improved pregnancy
Increased complications
Maternal and fetal risks

Pregnancy outcomes after liver transplantation (LT) are favorable, with a live birth rate of 80.4%. However, the risk of maternal and fetal complications is increased, including preterm birth (32.1%), preeclampsia (12.5%), and cesarean delivery (42.2%).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

28.

Auxiliary liver transplantation for management of acute liver failure in children - Systematic review.

Author: QuadrosJoana, PiedadeCláudia, LopesMaria Francelina

APOLT for PALF

This systematic review assessed auxiliary partial liver orthotopic transplantation (APOLT) for acute pediatric liver failure (PALF). APOLT offers a potential alternative to liver transplantation (LT) by providing a graft that supports liver function until the native liver recovers, potentially allowing for immunosuppression withdrawal.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

29.

Liver Transplantation for Non-Resectable Liver Metastases from Colorectal Cancer: A Systematic Review and Meta-Analysis.

Author: VarleyRebecca, TaraziMunir, DavéMadhav, MobarakShahd, StottMartyn C, BaltatzisMinas, SatyadasThomas

Treatment for NRCLM

This study compared the current evidence for liver transplantation for non-resectable colorectal liver metastases (NRCLM) with the current standard treatment of palliative chemotherapy. Historically, colorectal liver metastases were considered a contraindication to liver transplantation. However, advancements in liver transplantation (LT) and dismal outcomes for those with metastatic colorectal cancer have led to a renewed interest in the topic.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

32.

Right Lobe Versus Left Lobe Living Donor Liver Transplantation: A Systematic Review and Meta-analysis of Donor and Recipient Outcomes.

Author: AcunaSergio A, ZhangWei, YoonPeter D, IvanicsTommy, ZhuMary P, ClaasenMarco, ZuckermanJesse, GhanekarAnand, CattralMark S, SapisochinGonzalo

Improved outcomes
Reduced complications

This meta-analysis compared outcomes of right lobe (RL) and left lobe (LL) living donor liver transplantation (LDLT). LL donors experienced fewer complications than RL donors. LL-LDLT recipients had similar outcomes to RL-LDLT recipients. These findings suggest that LL-LDLT may be preferable for living donors.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

33.

SOULMATE: the Swedish study of liver transplantation for isolated colorectal cancer liver metastases not suitable for operation or ablation, compared to best established treatment-a randomized controlled multicenter trial.

Author: ReivellVeronica, HagmanHelga, HauxJohan, JornsCarl, LindnérPer, TaflinHelena

CRLM treatment
Liver graft shortage

This study discusses the potential of liver transplantation as a treatment option for selected patients with colorectal liver metastases (CRLM) who are not suitable for surgical intervention or ablation. Although non-randomized studies show positive results, further validation through a randomized controlled trial is needed before liver transplantation for CRLM can be implemented as standard clinical practice.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

34.

Rescue liver transplantation after post-hepatectomy acute liver failure: A systematic review and pooled analysis.

Author: AngelicoRoberta, SiragusaLeandro, SerenariMatteo, ScaleraIrene, KauffmanEmanuele, LaiQuirino, VitaleAlessandro,

Post-hepatectomy liver failure treatment

This systematic review examines the indication for rescue liver transplantation (LT) in patients with post-hepatectomy liver failure and the outcomes of LT. Post-hepatectomy liver failure is a severe complication after major liver surgery with a high mortality rate.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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