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A treatment for severe nodular acne: a randomized investigator-blinded, controlled, noninferiority trial comparing fixed-dose adapalene/benzoyl peroxide plus doxycycline vs. oral isotretinoin.

Author: , AudibertF, BarankinB, GooderhamM, HumphreyS, KerroucheN, LyndeC, TanJ, VenderR

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Doxycycline 200 mg plus adapalene 0.1%/benzoyl peroxide 2.5% gel (D+A/BPO) is a safe and effective alternative to oral isotretinoin (ISO) for severe nodular acne. In a randomized controlled trial, D+A/BPO showed an earlier onset of action and a favorable composite efficacy/safety profile compared to ISO.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Oral isotretinoin (ISO) is the gold standard for severe nodular acne. However, as some patients are unwilling or unable to take, or are intolerant to, ISO, other options are needed. OBJECTIVES: To compare efficacy and safety of oral ISO vs. doxycycline 200 mg plus adapalene 0·1%/benzoyl...See full text at original site
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引用元：
https://doi.org/10.1111/bjd.13191

データ提供：米国国立医学図書館（NLM）

Fighting Acne: A New Battle Plan

Severe nodular acne can be a difficult condition to treat, and oral isotretinoin (ISO) is often considered the gold standard. However, this study explores the efficacy and safety of an alternative treatment: adapalene/benzoyl peroxide plus doxycycline (D+A/BPO).

A New Weapon in the Fight Against Acne: Adapalene/Benzoyl Peroxide Plus Doxycycline

This study found that D+A/BPO showed a faster onset of action and was noninferior to ISO in treating severe nodular acne. Furthermore, D+A/BPO had fewer treatment-related side effects. This suggests that D+A/BPO could be a viable alternative for patients who are intolerant to or unable to take ISO.

Navigating the Desert of Acne Treatment: Finding the Right Oasis

This research provides a promising new option for treating severe nodular acne. It's like discovering a new oasis in the desert of acne treatment. However, it's important to remember that every individual's journey is unique, and finding the right treatment requires careful consideration of individual needs and potential risks.

Dr.Camel's Conclusion

D+A/BPO offers a valuable alternative to ISO for severe nodular acne. It's like finding a new path through the desert of acne treatment, but remember to choose the path that best suits your individual needs and potential challenges.

Date :
  1. Date Completed 2015-08-18
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

24934963

DOI: Digital Object Identifier

10.1111/bjd.13191

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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