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Ototoxicity of antimycotics.

Author: MarshR R, TomL W

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Five antimycotic preparations were tested for ototoxicity in guinea pigs. Preparations containing acetic acid or propylene glycol caused hearing impairment, while tolnaftate or clotrimazole solutions in polyethylene glycol 400 showed little to no ototoxicity.
Paper Details　
Original Abstract of the Article :
Neither otomycoses nor defects of the tympanic membrane are rare. In cases of fungal infection when the tympanic membrane is not intact, the possibility exists that antimycotic medication could enter the middle ear and diffuse into the cochlea via the round window. Five antimycotic preparations were...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://doi.org/10.1177/019459988910000209

データ提供：米国国立医学図書館（NLM）

Ototoxicity of Antimycotics: A Careful Approach

The ear is a delicate organ, like a precious oasis in the desert, susceptible to damage from various threats. This study delves into the potential ototoxicity of antimycotic medications, exploring how these drugs might affect the delicate balance of the inner ear. The researchers investigated the impact of different antimycotic formulations on hearing function in guinea pigs, seeking to understand which medications might pose a risk to this vital sense.

Navigating the Risks of Antimycotics

The study highlights the importance of careful consideration when prescribing antimycotics, particularly in cases of ear infections. It's like recognizing that certain desert plants might be poisonous and taking precautions to avoid them. By understanding the potential risks associated with different formulations, clinicians can make informed decisions to minimize the risk of hearing loss.

Protecting Hearing Health

This research serves as a reminder that even seemingly benign medications can have unintended consequences. It emphasizes the need for careful monitoring and evaluation when prescribing antimycotics, particularly in cases of ear infections. It's like taking extra care when navigating a desert terrain, ensuring that you have the right equipment and supplies to handle any unexpected challenges.

Dr.Camel's Conclusion

This study underscores the importance of careful consideration when using antimycotics, particularly in cases of ear infections. Just like a camel guide must be aware of the potential dangers in the desert, clinicians should be mindful of the potential ototoxicity of these medications to protect their patients' hearing health.
Date :
  1. Date Completed 1989-05-19
  2. Date Revised 2017-02-14
Further Info :

Pubmed ID

2495509

DOI: Digital Object Identifier

10.1177/019459988910000209

Related Literature

Article Analysis
・Effects of tolnaftate
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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