Does moxifloxacin alter oxidant status in the cornea? An experimental study.

Author: AkalAli, AksoyNurten, GoncuTugba, GuldurMuhammet Emin, KarakasEmel Yigit, KocarslanSezen, KoksalMete, OzkanUfuk, SavikEmin, TaskinAbdullah, UlasTurgay

Paper Details 
Original Abstract of the Article :
OBJECTIVE: In this experimental study, we investigated the possible effects of intracameral moxifloxacin on oxidative stress parameters and endothelial cell morphology in corneal tissue. METHODS: In total, 30 rats were randomly assigned to three groups of 10 rats: the sham group (Group 1, n = 10); ...See full text at original site
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引用元:
https://doi.org/10.3109/15569527.2014.918138

データ提供:米国国立医学図書館(NLM)

Moxifloxacin's Impact on Corneal Oxidative Stress: An Experimental Study

Moxifloxacin, a widely used antibiotic, is often administered intracamerally for eye infections. This study investigates the potential effects of moxifloxacin on corneal oxidative stress and endothelial cell morphology in an experimental setting.

Moxifloxacin: A Potential Threat to Corneal Health

The research suggests that intracameral moxifloxacin injection, while safe systemically, may have adverse effects on corneal tissues. The study found increased oxidative stress parameters and apoptotic activity in the cornea of rats treated with moxifloxacin, raising concerns about the potential for corneal toxicity. The findings underscore the importance of carefully considering the potential risks and benefits of moxifloxacin administration, particularly in the context of corneal health.

Navigating the Desert of Corneal Health

The cornea, like a delicate desert flower, is susceptible to environmental stressors. This research reminds us that even commonly used medications can have unforeseen consequences, highlighting the need for further investigation and cautious use. The findings underscore the importance of understanding the potential risks and benefits of different treatment options, particularly when it comes to delicate tissues like the cornea.

Dr. Camel's Conclusion

Just like a desert traveller must carefully choose their path to avoid treacherous sands, eye doctors must carefully consider the potential risks of using moxifloxacin. This study sheds light on the potential for corneal toxicity associated with this antibiotic. It's a reminder that the desert of medical knowledge is vast, and we must continually explore the potential consequences of our interventions to ensure the well-being of our patients.
Date :
  1. Date Completed 2016-06-06
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

24964171

DOI: Digital Object Identifier

10.3109/15569527.2014.918138

Related Literature

SNS
PICO Info
in preparation
Languages

English

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