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Should the standard dimethyl sulfoxide concentration be reduced? Results of a European Group for Blood and Marrow Transplantation prospective noninterventional study on usage and side effects of dimethyl sulfoxide.

Author: , ApperleyJane, BrandRonald, ChiusoloPatrizia, DickmeissEbbe, HentrichMarcus, KrogerNicolaus, LenhoffStig, MartinelliGiovanni, MorrisCurly, OnidaFrancesco, PabstThomas, QuinnMichael, RuutuTapani, ScholtenMarijke, SuredaAnna, TrnenyMarek, de WitteTheo, de WreedeLiesbeth, van BiezenAnja, van ImhoffGustaaf W

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Dimethyl sulfoxide (DMSO) is essential for preserving frozen stem cells but can cause toxicity. The use of lower DMSO concentrations and cell washing before infusion may reduce toxicity. Patients receiving higher doses of DMSO experienced more side effects, suggesting the need for better standardization and dose control.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Dimethyl sulfoxide (DMSO) is essential for the preservation of liquid nitrogen-frozen stem cells, but is associated with toxicity in the transplant recipient. STUDY DESIGN AND METHODS: In this prospective noninterventional study, we describe the use of DMSO in 64 European Blood and Marr...See full text at original site
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引用元：
https://doi.org/10.1111/trf.12759

データ提供：米国国立医学図書館（NLM）

Dimethyl Sulfoxide (DMSO): Balancing Preservation and Toxicity in Stem Cell Transplantation

This study examines the use of dimethyl sulfoxide (DMSO) in stem cell transplantation, focusing on its role in preserving frozen stem cells and its potential toxicity in recipients. The research analyzes data from a prospective non-interventional study involving 64 European Blood and Marrow Transplant Group centers. The study found that while many centers continue to use 10% DMSO, a significant proportion are using lower concentrations or washing cells before infusion. The study highlights the need for further standardization of DMSO use to minimize potential toxicity and improve patient outcomes.

Optimizing DMSO Use in Stem Cell Transplantation

This research underscores the need for a balanced approach to using dimethyl sulfoxide (DMSO) in stem cell transplantation. The study highlights the importance of minimizing potential toxicity while ensuring effective preservation of stem cells. It recommends further standardization of DMSO use, including exploring lower concentrations or cell washing techniques, to improve patient outcomes.

Navigating the Sands of Stem Cell Transplantation

This research provides valuable insights into the intricate details of stem cell transplantation. Just as a camel navigates a desert, carefully choosing its path, we must navigate the complexities of this procedure, balancing the benefits of stem cell preservation with the potential risks associated with DMSO. This study emphasizes the importance of continuous research and optimization to ensure safe and effective transplantation practices.

Dr.Camel's Conclusion

This research highlights the need for a balanced approach to using dimethyl sulfoxide (DMSO) in stem cell transplantation. It underscores the importance of minimizing potential toxicity while ensuring effective preservation of stem cells. The study emphasizes the importance of continuous research and standardization to optimize DMSO use and improve patient outcomes.

Date :
  1. Date Completed 2014-12-31
  2. Date Revised 2022-03-31
Further Info :

Pubmed ID

24964911

DOI: Digital Object Identifier

10.1111/trf.12759

Related Literature

Article Analysis
・Side Effects of dimethyl sulfoxide (dmso)
SNS
PICO Info
in preparation
Languages

English

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