L-658,310, a new injectable cephalosporin. I. In vitro antibacterial properties.

Author: AbruzzoG K, FromtlingR A, GadebuschH H, GillC, PonticasS, ShunguD L, ValiantM E, WeissbergerB A

Paper Details 
Original Abstract of the Article :
The in vitro antibacterial spectrum of L-658,310, a new semisynthetic cephalosporin, was compared with ceftazidime, aztreonam and piperacillin against a wide variety of randomly selected human clinical isolates. The compound was found to be a broad spectrum bactericidal agent that was more potent th...See full text at original site
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引用元:
https://doi.org/10.7164/antibiotics.42.795

データ提供:米国国立医学図書館(NLM)

Introducing L-658,310: A Novel Injectable Cephalosporin

This study delves into the realm of [antimicrobial drug development] – the investigation of a new semisynthetic cephalosporin, L-658,310, for its in vitro antibacterial properties. The study employed a [comparative analysis] approach to assess the antibacterial spectrum and potency of L-658,310 against a wide range of clinical isolates, comparing it to established antibiotics like ceftazidime, aztreonam, and piperacillin. The study found that L-658,310 demonstrated broad-spectrum bactericidal activity and exhibited superior potency against glucose nonfermenting bacteria, including multi-resistant strains of Pseudomonas aeruginosa. The researchers attributed this enhanced activity to the presence of dihydroxy substituents on the 2-methylisoindoline moiety of L-658,310.

A Promising New Cephalosporin: L-658,310

The findings highlight L-658,310 as a promising new cephalosporin with potent antibacterial activity, particularly against multi-resistant bacteria. This research underscores the need for continued development of novel antibiotics to combat the growing challenge of antimicrobial resistance.

Battling Antimicrobial Resistance: A Global Challenge

This study underscores the ongoing battle against antimicrobial resistance. Developing new antibiotics is crucial to ensure effective treatment options for bacterial infections. As a wise old camel, I've always said that we must stay vigilant in our fight against these tenacious microbes.

Dr.Camel's Conclusion

This study introduces L-658,310, a promising new cephalosporin with potent antibacterial activity. It highlights the importance of continued research in antimicrobial drug development to combat the growing threat of antimicrobial resistance.

Date :
  1. Date Completed 1989-06-30
  2. Date Revised 2019-07-23
Further Info :

Pubmed ID

2498277

DOI: Digital Object Identifier

10.7164/antibiotics.42.795

Related Literature

SNS
PICO Info
in preparation
Languages

English

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