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Precision cut intestinal slices are an appropriate ex vivo model to study NSAID-induced intestinal toxicity in rats.

Author: GroothuisGeny M M, NiuXiaoyu, de GraafInge A M, van der BijHendrik A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Rat precision cut intestinal slices (PCIS) were evaluated as an ex vivo model to study NSAID-induced intestinal toxicity. The model accurately reflected various mechanisms of diclofenac-induced toxicity. PCIS were then used to assess the toxicity of five NSAIDs, and the results showed good correlation with published in vitro and in vivo data.
Paper Details　
Original Abstract of the Article :
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used therapeutic agents, however, they are associated with a high prevalence of intestinal side effects. In this investigation, rat precision cut intestinal slices (PCIS) were evaluated as an ex vivo model to study NSAID-induced intestinal to...See full text at original site
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引用元：
https://doi.org/10.1016/j.tiv.2014.06.010

データ提供：米国国立医学図書館（NLM）

Precision Cut Intestinal Slices: A Model for Studying NSAID-Induced Intestinal Toxicity

The desert of drug discovery is a vast and unpredictable landscape, where researchers constantly strive to understand the potential side effects of medications. This study focuses on NSAIDs (non-steroidal anti-inflammatory drugs), a class of medications commonly used to relieve pain and inflammation. Researchers sought to develop a reliable ex vivo model using precision cut intestinal slices (PCIS) to study the intestinal toxicity induced by NSAIDs.

PCIS: A Valuable Tool for Studying NSAID Toxicity

This study, like a skilled caravan leader navigating a challenging desert, demonstrates the potential of PCIS as a valuable tool for studying NSAID-induced intestinal toxicity. The researchers showed that PCIS accurately reflect the toxic mechanisms of NSAIDs, including morphological damage, ATP depletion, and the activation of various cellular pathways involved in toxicity. This finding provides a valuable platform for further research into the mechanisms of NSAID-induced intestinal damage.

Navigating the Desert of Drug Safety

This research, like a beacon of light in the desert, emphasizes the importance of developing reliable and efficient models for studying drug toxicity. The use of PCIS offers a promising approach for understanding the mechanisms of drug-induced side effects, facilitating the development of safer and more effective medications.

Dr. Camel's Conclusion

This study, like a well-stocked caravan, provides researchers with a valuable tool for navigating the desert of drug safety. The development of PCIS as a reliable model for studying NSAID-induced intestinal toxicity offers a promising path towards minimizing the risks associated with these essential medications.

Date :
  1. Date Completed 2015-03-31
  2. Date Revised 2021-03-09
Further Info :

Pubmed ID

25014874

DOI: Digital Object Identifier

10.1016/j.tiv.2014.06.010

Related Literature

Article Analysis
・Side Effects of diflunisal
SNS
PICO Info
in preparation
Languages

English

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