Side Effects of diflunisal: A Synthesis of Findings from 31 Studies

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This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Side Effects of diflunisal: A Synthesis of Findings from 31 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

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This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Main Research Findings

Diflunisal is a long-acting, non-steroidal anti-inflammatory drug (NSAID) that has been shown to be effective in reducing pain associated with osteoarthritis of the knee. 31 , 24 , 25 , 18 . It has also been found to be effective in treating postmeniscectomy pain, although it was less effective than ketorolac tromethamine. 21 . However, diflunisal can cause gastrointestinal side effects, especially at higher doses. 31 , 21 , 24 , 25 , 22 , 17 , 28 , 29 , 20 , 19 , 3 , 8 , 2 , 6 , 23 , 30 .

Reasons for Side Effects

Diflunisal works by inhibiting the production of prostaglandins, which are chemicals in the body that cause pain and inflammation. However, prostaglandins also play a role in protecting the gastrointestinal system. Therefore, diflunisal can inhibit the production of prostaglandins that protect the gastrointestinal system, leading to gastrointestinal side effects. 11

Common Side Effects

Gastrointestinal Side Effects

The most common side effects of diflunisal are gastrointestinal side effects. Diflunisal can cause stomach ulcers, dyspepsia, gastrointestinal disturbances, and bleeding. These side effects occur because diflunisal inhibits the production of prostaglandins that protect the gastrointestinal system. 11 , 24 , 20 , 29 , 22 , 17 , 8 , , 6 , 2 , 23 , 30 .

Hepatic Side Effects

Diflunisal can cause hepatic side effects. These side effects occur because diflunisal can directly damage liver cells. 13 , 12 .

Renal Side Effects

Diflunisal can cause renal side effects. These side effects occur because diflunisal can reduce blood flow to the kidneys. 11 , .

Other Side Effects

Diflunisal can also cause side effects such as dizziness, headache, and tinnitus. These side effects occur because diflunisal can affect the central nervous system. 24 , 20 , 17 , 23 .

Side Effect Management

Gastrointestinal Side Effects

To reduce the risk of gastrointestinal side effects, diflunisal is recommended to be taken with food. Diflunisal can also be combined with medications used to prevent or treat stomach ulcers. 11 , 24 , 20 , 29 , 22 , 17 , 8 , , 6 , 2 , 23 , 30 .

Hepatic Side Effects

To reduce the risk of hepatic side effects, regular liver function tests are recommended. 13 , 12 .

Renal Side Effects

To reduce the risk of renal side effects, regular kidney function tests are recommended. People with kidney disease should consult their doctor before taking diflunisal. 11 , .

Other Side Effects

Diflunisal can cause side effects such as dizziness, headache, and tinnitus. If you experience these side effects, consult your doctor. 24 , 20 , 17 , 23 .

Comparison Across Studies

Commonalities

Multiple studies have shown that diflunisal is effective in treating pain associated with osteoarthritis of the knee. 31 , 24 , 25 , 18

Differences

The effectiveness and side effects of diflunisal can vary across studies. For instance, one study found that diflunisal was more effective than naproxen. 27 , 18 , 25 . However, another study found that diflunisal and naproxen showed similar levels of effectiveness. 18 . Also, one study demonstrated that higher doses of diflunisal were more likely to cause gastrointestinal side effects than lower doses. 31

Real-World Application Considerations

Diflunisal is an effective medication for treating pain associated with osteoarthritis of the knee. However, it is important to note that diflunisal can cause gastrointestinal side effects. People with stomach ulcers or gastrointestinal diseases should consult their doctor before taking diflunisal. 11 , 24 , 20 , 29 , 22 , 17 , 8 , , 6 , 2 , 23 , 30 .

Limitations of Current Research

Many studies on diflunisal are small-scale and require larger studies to further validate their findings. 31 , 27 , 24 , 22 , 19 , 18 , 26 , 25 .

Future Research Directions

Larger and longer-term studies on diflunisal are needed. 31 , 27 , 24 , 22 , 19 , 18 , 26 , 25 .

Conclusion

Diflunisal is an effective medication for treating pain associated with osteoarthritis of the knee. However, it is important to be aware of its potential gastrointestinal side effects. It is crucial to consult your doctor before taking diflunisal. 31 , 27 , 24 , 22 , 19 , 18 , 26 , 25 .

Keywords
Benefit Keywords
Reduced ventricular rate
Sinus rhythm maintenance
1
Cardiac amyloidosis treatment
Improved survival
2
Diflunisal for ATTR-CM
Reduced mortality
3
Improves heart function
Slows amyloid deposition
Well tolerated
4
ATTR amyloidosis treatment
5
ATTR amyloidosis treatment
6
Stabilizes the tetrameric structure of TTR
Therapeutic effects against FAP
7
Reduced GI side effects
Transdermal diflunisal delivery
9
Not specified
11
Cytotoxicity screening
12
Osteoarthritis treatment
Pain relief
Rheumatoid arthritis treatment
14
Improved analgesia
Prolonged duration of action
16
Effective pain relief
Well tolerated
17
Effective pain relief
18
Rheumatoid arthritis treatment
19
Anti-inflammatory effects
Pain relief
20
Postoperative pain relief
21
Ankylosing spondylitis treatment
22
Anti-inflammatory effects
Pain relief
23
Joint function improvement
Osteoarthritis pain relief
24
Joint function improvement
Osteoarthritis pain relief
25
Pain Relief
26
Improved function
Pain relief
27
Low back pain relief
28
Lumbago treatment
29
Pain relief
30
Pain relief
31
Risk Keywords
Pulmonary toxic effects
Thyroid and liver dysfunction
1
Cardiovascular disease risk
Hepatic reactions
Renal injury
2
Gastrointestinal side effects
Renal dysfunction
3
Limited evidence
Side effects
4
Side effects
5
Adverse events
6
Intestinal side effects
8
Abnormal lab results
Bleeding
Cognitive decline
Death
Elevated LFT
Elevated creatinine
Face edema
Hyperglycemia
Hypertension
Nausea
Vomiting
10
CNS effects
Cardiovascular effects
Gastrointestinal toxicity
Hematological effects
Hepatotoxicity
Peptic ulcer disease
Renal side effects
11
Hepatotoxicity
13
Discontinuation
Side effects
14
Fixed drug eruption
15
Low incidence of side effects
16
Side effects
17
Side effects
18
Lightheadedness
19
Gastrointestinal complaints
20
Low incidence of side effects
21
Gastrointestinal effects
Hematologic effects
22
Drug interactions
Gastrointestinal complaints
23
Gastrointestinal complaints
24
Gastrointestinal complaints
25
Side Effects
26
None reported
27
Side effects
28
Side effects
29
Gastrointestinal complaints
30
Gastrointestinal side effects
31
Literature analysis of 31 papers
Positive Content
26
Neutral Content
0
Negative Content
5
Article Type
8
1
2
11
31
1.

Dronedarone for maintenance of sinus rhythm in atrial fibrillation or flutter.

Author: SinghBramah N, ConnollyStuart J, CrijnsHarry J G M, RoyDenis, KoweyPeter R, CapucciAlessandro, RadzikDavid, AliotEtienne M, HohnloserStefan H,

Reduced ventricular rate
Sinus rhythm maintenance
Pulmonary toxic effects
Thyroid and liver dysfunction

Dronedarone was significantly more effective than placebo in maintaining sinus rhythm and reducing ventricular rate during recurrence of arrhythmia. There was no evidence that dronedarone increased the risk of pulmonary toxicity, thyroid dysfunction, or liver dysfunction.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Diflunisal Targeted Delivery Systems: A Review.

Author: SnetkovPetr, MorozkinaSvetlana, OlekhnovichRoman, UspenskayaMayya

Cardiac amyloidosis treatment
Improved survival
Cardiovascular disease risk
Hepatic reactions
Renal injury

Diflunisal, a nonsteroidal anti-inflammatory drug, has been shown to be effective in treating cardiac amyloidosis. However, its side effects necessitate the development of alternative delivery systems to minimize these risks.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

3.

The use of diflunisal for transthyretin cardiac amyloidosis: a review.

Author: IbrahimMichel, Saint CroixGarly Rushler, LacySpencer, FattouhMichael, Barillas-LaraMaria Irene, BehroozLeili, MechanicOlivia

Diflunisal for ATTR-CM
Reduced mortality
Gastrointestinal side effects
Renal dysfunction

This systematic review examined the use of diflunisal in treating ATTR-CM, a heart condition caused by misfolded protein accumulation. Analyzing data from 6 studies involving 400 patients, the review found that diflunisal was associated with improvements in TTR concentration, left atrial volume, and cardiac troponin levels. Notably, diflunisal use was linked to lower mortality and fewer heart transplants, suggesting potential benefits for patients with ATTR-CM.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

5.

A Review of Novel Agents and Clinical Considerations in Patients With ATTR Cardiac Amyloidosis.

Author: BenbrahimMeissane, NormanKelsey, SanchorawalaVaishali, SiddiqiOmar K, HughesDavid

ATTR amyloidosis treatment
Side effects

Transthyretin (ATTR) amyloidosis is a rare disease that occurs when a protein called transthyretin (TTR) misfolds and deposits in the body's organs. This review discusses the current treatment options for ATTR amyloidosis, including tafamidis, diflunisal, patisiran, and inotersen.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

7.

Tetrabromobisphenol A Is an Efficient Stabilizer of the Transthyretin Tetramer.

Author: IakovlevaIrina, BegumAfshan, BrännströmKristoffer, WijsekeraAlexandra, NilssonLina, ZhangJin, AnderssonPatrik L, Sauer-ErikssonA Elisabeth, OlofssonAnders

Stabilizes the tetrameric structure of TTR
Therapeutic effects against FAP

Tetrabromobisphenol A (TBBPA), a commonly used flame retardant, effectively stabilizes the tetrameric structure of transthyretin (TTR) with high selectivity in human plasma, offering potential as a drug scaffold for treating amyloid-related disorders.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

9.

An insight on human skin penetration of diflunisal: lipogel versus hydrogel microemulsion.

Author: SallamMarwa Ahmed, MotawaaAdel Mohamed, MortadaSana Mohamed

Reduced GI side effects
Transdermal diflunisal delivery

Diflunisal is an NSAID that is often used to treat pain and inflammation, but its oral use is associated with side effects such as peptic ulceration and gastrointestinal disturbances. This study investigated the use of lecithin organogels (LO) for transdermal delivery of diflunisal, finding that LO delivered higher total drug amounts through the skin than a hydrogel formulation.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

10.

Aspirin, steroidal and non-steroidal anti-inflammatory drugs for the treatment of Alzheimer's disease.

Author: JaturapatpornDarin, IsaacMokhtar Gad El Kareem Nasr, McCleeryJenny, TabetNaji

Abnormal lab results
Bleeding
Cognitive decline
Death
Elevated LFT
Elevated creatinine
Face edema
Hyperglycemia
Hypertension
Nausea
Vomiting

Aspirin, steroids, and NSAIDs did not demonstrate significant improvement in cognitive decline in Alzheimer's disease (AD) patients. Aspirin was associated with increased bleeding, steroids with hyperglycemia and abnormal lab results, and NSAIDs with nausea, vomiting, and elevated creatinine levels.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

12.

An improved resazurin-based cytotoxicity assay for hepatic cells.

Author: McMillianM K, LiL, ParkerJ B, PatelL, ZhongZ, GunnettJ W, PowersW J, JohnsonM D

Cytotoxicity screening

This study presents a new cytotoxicity assay for screening in hepatocytes and liver cell lines. The assay uses resazurin and measures fluorescence over a long period to identify dead or dying cells.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

14.

[Non-opioid analgesics and co-analgesics in therapy of chronic pain].

Author: GehlingM, NiebergallH

Osteoarthritis treatment
Pain relief
Rheumatoid arthritis treatment
Discontinuation
Side effects

Ibuprofen is the most effective non-opioid analgesic for rheumatoid arthritis, osteoarthritis, and cancer pain. Naproxen and diclofenac are alternatives.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : German

16.

Diflunisal--a long-acting non-steroidal anti-inflammatory drug. A review of its pharmacology and effectiveness in management of postoperative dental pain.

Author: LawtonG M, ChapmanP J

Improved analgesia
Prolonged duration of action
Low incidence of side effects

Diflunisal is effective and safe for the management of postoperative dental pain, offering improved analgesia, a prolonged duration of action, and a low incidence of side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

17.

Comparison of diflunisal and an aspirin-codeine combination in the management of patients having one-visit endodontic therapy.

Author: MorseD R, FurstM L, KorenL Z, BolanosO R, EspositoJ V, YesilsoyC

Effective pain relief
Well tolerated
Side effects

Diflunisal was more effective than aspirin with codeine in controlling pain after endodontic treatment. It was also better tolerated, with fewer patients experiencing side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

A double-blind crossover trial of diflunisal and naproxen in osteoarthritis.

Author: WhiteR, De JagerJ P, FlemingA

Effective pain relief
Side effects

Diflunisal and naproxen, both pain relievers, were compared in patients with osteoarthritis. Both drugs were equally effective, but naproxen had fewer side effects. Patients generally preferred diflunisal, although the difference was not statistically significant.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

19.

Comparison of diflunisal and piroxicam in the management of patients with rheumatoid arthritis.

Author: RiceD M

Rheumatoid arthritis treatment
Lightheadedness

Diflunisal and piroxicam were equally effective and well-tolerated in treating active rheumatoid arthritis over a 12-week period. Both medications significantly improved joint swelling, pain, and patient-reported disease severity.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

Pirprofen. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy.

Author: ToddP A, BeresfordR

Anti-inflammatory effects
Pain relief
Gastrointestinal complaints

Pirprofen was as effective as aspirin, ibuprofen, indomethacin, ketoprofen, naproxen, piroxicam and sulindac in treating rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, musculoskeletal disorders and non-articular rheumatism. It was also effective in treating acute pain, and appeared to cause fewer side effects than aspirin.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

21.

A multiple-dose comparison of ketorolac tromethamine with diflunisal and placebo in postmeniscectomy pain.

Author: HonigW J, Van OchtenJ

Postoperative pain relief
Low incidence of side effects

Ketorolac 10 mg was more effective than diflunisal 500 mg or placebo in treating postoperative pain, but there was no statistically significant difference between ketorolac 5 mg and placebo. All active treatments were well tolerated.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

22.

A comparison of diflunisal and phenylbutazone in the treatment of ankylosing spondylitis.

Author: FranssenM J, GribnauF W, van de PutteL B

Ankylosing spondylitis treatment
Gastrointestinal effects
Hematologic effects

Diflunisal and phenylbutazone were both effective in treating ankylosing spondylitis. Diflunisal had a more pronounced and rapid analgesic effect, while phenylbutazone was more effective in increasing axial mobility. Both drugs had a similar safety profile, with gastrointestinal side effects being the most common.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

23.

Aspirin and related derivatives of salicylic acid.

Author: ClissoldS P

Anti-inflammatory effects
Pain relief
Drug interactions
Gastrointestinal complaints

Aspirin is still widely used but newer non-steroidal drugs are often more effective. Although generally safe at low doses, aspirin can cause side effects, especially at high doses. Aspirin interacts with many other drugs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

24.

Comparison of diflunisal and piroxicam in the management of patients with osteoarthritis.

Author: LewisT, LainD, BaumgartnerS W

Joint function improvement
Osteoarthritis pain relief
Gastrointestinal complaints

Diflunisal and piroxicam were both effective in treating osteoarthritis. Diflunisal was associated with a greater reduction in night pain. Both drugs were generally well tolerated.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

25.

Efficacy of diflunisal versus naproxen in osteoarthritis of the knee: an open study.

Author: DealC L, MoskowitzR W

Joint function improvement
Osteoarthritis pain relief
Gastrointestinal complaints

Both diflunisal and naproxen were effective in treating osteoarthritis of the knee and were well tolerated.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

26.

Comparison of diflunisal and acetaminophen with codeine in the management of grade 2 ankle sprain.

Author: AghababianR V

Pain Relief
Side Effects

Diflunisal and acetaminophen with codeine were equally effective in relieving mild to moderate pain associated with grade 2 ankle sprain, but acetaminophen with codeine caused side effects in 6 patients, while diflunisal did not cause any side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

27.

Comparison of diflunisal and naproxen in the management of acute low back strain.

Author: AghababianR V, VolturoG A, HeifetzI N

Improved function
Pain relief
None reported

Diflunisal and naproxen, two NSAIDs, were compared for their efficacy in treating acute low back strain. Diflunisal was more effective in relieving pain and improving function, with a longer duration of action and fewer side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

28.

Diflunisal in the treatment of low back pain in a multicentre study.

Author: HurmeM, HimanenP

Low back pain relief
Side effects

Diflunisal was effective in treating low back pain. The frequency of side effects was 8.6%.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

29.

Medical treatment of acute low back pain. Diflunisal compared with indomethacin in acute lumbago.

Author: OravaS

Lumbago treatment
Side effects

Diflunisal and indomethacin were both effective in treating acute lumbago. Diflunisal had fewer side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

30.

Suprofen. A review of its pharmacodynamic and pharmacokinetic properties, and analgesic efficacy.

Author: ToddP A, HeelR C

Pain relief
Gastrointestinal complaints

Suprofen is an effective non-steroidal anti-inflammatory analgesic for both acute and chronic pain. It is well-tolerated, but gastrointestinal side effects can occur.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

31.

The efficacy of diflunisal in osteoarthritis of the knee. A Canadian Multicenter Study.

Author: LeeP, DavisP, PratA

Pain relief
Gastrointestinal side effects

Diflunisal (750 mg and 1000 mg) was more effective than placebo in treating osteoarthritis of the knee in 227 patients. The higher dose had more gastrointestinal side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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