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Add-on histamine receptor-3 antagonist for allergic rhinitis: a double blind randomized crossover trial using the environmental exposure unit.

Author: AllanRichard J, DayAndrew G, EllisAnne K, HackmanFrances, HobsbawnBarnaby G, NorthMichelle L, SteacyLisa M, SunXiaoqun, WalkerTerry J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Fexofenadine is an antihistamine that is often used to treat allergic rhinitis. However, it is not very effective at relieving nasal congestion. Combining fexofenadine with pseudoephedrine, a decongestant, can help to relieve congestion, but this combination can cause side effects. This study looked at the potential of using histamine receptor-3 antagonists, such as PF-03654764, to relieve nasal congestion. Previous studies in animals and humans have shown that histamine receptor-3 antagonists may be effective in treating nasal congestion.
Paper Details　
Original Abstract of the Article :
Oral antihistamines that target the histamine receptor-1, such as fexofenadine, offer suboptimal relief of allergic rhinitis-associated nasal congestion. Combinations with oral sympathomimetics, such as pseudoephedrine, relieve congestion but produce side effects. Previous animal and human studies w...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094756/

データ提供：米国国立医学図書館（NLM）

Allergic Rhinitis: Targeting Histamine Receptors

Allergic rhinitis, commonly known as hay fever, can be a frustrating condition. This study investigates the potential of histamine receptor-3 antagonists as an add-on treatment for allergic rhinitis. The research examines the efficacy of PF-03654764, a histamine receptor-3 antagonist, in relieving nasal congestion associated with allergic rhinitis. The study utilizes an environmental exposure unit to simulate real-world conditions and assess the effectiveness of this novel treatment approach.

A New Oasis for Allergy Relief

The study shows promise for histamine receptor-3 antagonists in treating allergic rhinitis. Imagine a traveler in the desert finding a refreshing oasis, offering relief from the harsh conditions. Similarly, histamine receptor-3 antagonists offer a potential new avenue for alleviating nasal congestion associated with allergic rhinitis. The research suggests that PF-03654764 may be a valuable addition to existing treatment options, providing a more comprehensive approach to managing allergic rhinitis.

Navigating the Desert of Allergies

This research opens a new chapter in the treatment of allergic rhinitis. Like a camel caravan exploring new trails, researchers are continuously seeking innovative ways to alleviate the symptoms of this common condition. The study highlights the potential of histamine receptor-3 antagonists as a promising new therapy, offering hope for improved allergy management in the future.

Dr. Camel's Conclusion

This study explores the exciting potential of histamine receptor-3 antagonists in treating allergic rhinitis. Like finding a hidden oasis in the desert, this novel treatment approach offers hope for a more effective and comprehensive approach to managing this common condition.

Date :
  1. Date Completed 2014-07-15
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

25024716

DOI: Digital Object Identifier

PMC4094756

SNS
PICO Info
in preparation
Languages

English

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