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Topotecan-tamoxifen duple PLGA polymeric nanoparticles: investigation of in vitro, in vivo and cellular uptake potential.
Author: IqbalZeenat, KhurooTahir, PadhiSantwana, PandaAmulya K, TalegaonkarSushama, VermaDevina
Original Abstract of the Article :
The dual drug loaded poly(dl-lactic-co-glycolic acid) (PLGA(1)) nanoparticles (TOP-TAM NPs(2)) concurrently delivering topotecan hydrochloride (TOP(3)) and tamoxifen citrate (TAM(4)) were developed to achieve synergism for the treatment of breast cancer by enhancing the permeation of TOP through the...See full text at original site
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引用元：
https://doi.org/10.1016/j.ijpharm.2014.07.022
データ提供：米国国立医学図書館（NLM）
Topotecan-Tamoxifen Nanoparticles for Breast Cancer: Enhanced Delivery and Synergistic Effects
The development of effective cancer therapies often involves innovative approaches to drug delivery. This research explores the potential of dual-drug loaded polymeric nanoparticles to improve the treatment of breast cancer. The researchers developed nanoparticles containing both topotecan hydrochloride (TOP) and tamoxifen citrate (TAM), aiming to enhance the delivery of these drugs and achieve synergistic effects.
Topotecan-Tamoxifen Nanoparticles Show Promise in Breast Cancer Treatment
The study indicates that topotecan-tamoxifen nanoparticles (TOP-TAM NPs) hold promise as a novel therapeutic approach for breast cancer. The researchers found that the nanoparticles effectively delivered both drugs, enhancing the permeation of TOP through the gut and into breast cancer cells. The study also suggests that the combination of TOP and TAM may have synergistic effects, potentially leading to improved therapeutic outcomes.
Implications for Breast Cancer Treatment
This research offers a glimpse into the future of breast cancer treatment. The study's findings suggest that TOP-TAM NPs could offer a more effective and targeted approach to delivering chemotherapy drugs, potentially improving outcomes and reducing side effects. This research encourages further investigation of nanoparticle-based drug delivery systems as a promising strategy for breast cancer therapy.
Dr. Camel's Conclusion
This research explores a promising new approach to treating breast cancer, like finding a hidden oasis in a vast desert. TOP-TAM NPs, like a camel carrying a precious cargo, offer a more effective and targeted way to deliver chemotherapy drugs, potentially leading to improved outcomes and reduced side effects for breast cancer patients. This research encourages continued exploration of nanoparticle-based drug delivery systems as a promising avenue for breast cancer therapy.
Date :
- Date Completed 2015-05-14
- Date Revised 2022-04-08
Further Info :
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