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Methotrexate for induction of remission in refractory Crohn's disease.

Author: FeaganBrian G, MacDonaldJohn K, McDonaldJohn W D, TsoulisDavid J, WangYongjun

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This systematic review updates previous research on the use of methotrexate for treating refractory Crohn's disease. Methotrexate has been explored as an alternative to azathioprine or 6-mercaptopurine for inducing remission in Crohn's disease, and this review examines the current evidence for its efficacy and safety.
Paper Details　
Original Abstract of the Article :
Although corticosteroids are effective for induction of remission of Crohn's disease, many patients relapse when steroids are withdrawn or become steroid dependent. Furthermore, corticosteroids exhibit significant adverse effects. The success of methotrexate as a treatment for rheumatoid arthritis l...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154581/

データ提供：米国国立医学図書館（NLM）

Methotrexate for Refractory Crohn's Disease: A Camel's Perspective on Gut Health

The desert of inflammatory bowel disease (IBD), like a vast and unforgiving landscape, can be a source of great suffering. This research explores the potential of methotrexate, a medication traditionally used to treat rheumatoid arthritis, as a treatment for refractory Crohn's disease, a severe form of IBD that often fails to respond to conventional therapies. The researchers, like skilled desert guides, sought to determine whether methotrexate could effectively induce remission in patients with refractory Crohn's disease.

Methotrexate: A Potential Oasis in the Desert of Crohn's Disease

The study, like a caravan searching for a source of water, examined the efficacy of methotrexate in inducing remission in patients with refractory Crohn's disease. The results suggest that methotrexate, like a hidden spring, may offer a valuable treatment option for these patients, providing an alternative to other medications with potential side effects. This research, like a beacon of hope in the desert, offers a glimmer of possibility for patients struggling with this debilitating condition.

Navigating the Desert of Crohn's Disease: A Camel's Guide

This research offers a promising avenue for treating refractory Crohn's disease. While further research is needed to fully understand the long-term effects and optimize treatment strategies, methotrexate appears to hold potential as a valuable addition to the therapeutic arsenal for this challenging condition. Just as a camel adapts to the harsh desert environment, we must remain open to new and innovative treatments for IBD.

Dr.Camel's Conclusion

This research highlights the potential of methotrexate as a treatment option for refractory Crohn's disease. While more research is needed, methotrexate offers a glimmer of hope for patients struggling with this challenging condition. The desert of IBD is vast and complex, but with continued research and innovative therapies, we can find pathways to healing and well-being.

Date :
  1. Date Completed 2014-09-19
  2. Date Revised 2023-11-13
Further Info :

Pubmed ID

25099640

DOI: Digital Object Identifier

PMC7154581

SNS
PICO Info
in preparation
Languages

English

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