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PDGF-BB does not accelerate healing in diabetic mice with splinted skin wounds.
Author: AbbottNicholas L, CovertJill, DubielzigRichard, IsseroffRoslyn Rivkah, McAnultyJonathan, MottaMonica J, MurphyChristopher J, ParkShin Ae, RaghunathanVijay Krishna, SchurrMichael, ShahNihar M, TeixeiraLeandro
Original Abstract of the Article :
Topical application of platelet-derived growth factor-BB (PDGF-BB) is considered to accelerate tissue repair of impaired chronic wounds. However, the vast literature is plagued with conflicting reports of its efficacy in animal models and this is often influenced by a wide array of experimental vari...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133340/
データ提供:米国国立医学図書館(NLM)
PDGF-BB: A Complex Role in Wound Healing
The study of wound healing is like navigating a complex desert of cellular signaling pathways and regenerative processes. This study, published in the Wound Repair and Regeneration, investigates the efficacy of platelet-derived growth factor-BB (PDGF-BB) in accelerating healing in diabetic mice with splinted skin wounds. The researchers employed a controlled, splinted wound model to evaluate the effects of PDGF-BB on wound closure and re-epithelialization. This study provides valuable insights into the complex role of PDGF-BB in wound healing and highlights the importance of considering the specific wound model when evaluating the efficacy of therapeutic agents.
PDGF-BB: A Mixed Bag in Wound Healing
The study found that PDGF-BB, despite being bioactive in vitro, failed to accelerate wound healing in vivo in diabetic mice. This finding suggests that the efficacy of PDGF-BB in wound healing is complex and may vary depending on the specific wound model and other factors. It's like discovering a water source in the desert that appears promising, but upon closer inspection, it's found to be contaminated and unusable.
Navigating the Desert of Wound Healing Research
This study emphasizes the importance of carefully considering the wound model used when evaluating therapeutic agents. It highlights the need for more comprehensive research to understand the complex role of PDGF-BB in wound healing and identify the factors that influence its efficacy. It's like using a GPS device to navigate the desert of wound healing research, ensuring that we choose the right path and avoid dead ends.
Dr. Camel's Conclusion
This study is a reminder that the desert of wound healing research is filled with hidden complexities. We must continue to explore different wound models and investigate the intricate interplay of factors that influence the efficacy of therapeutic agents. By carefully navigating this complex landscape, we can develop more effective treatments and improve the lives of patients with chronic wounds.
Date :
- Date Completed 2015-04-17
- Date Revised 2021-10-21
Further Info :
Related Literature
English
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