Effects of becaplermin topical: A Synthesis of Findings from 27 Studies

  1. Home
  2. Effects of becaplermin topical
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Effects of becaplermin topical: A Synthesis of Findings from 27 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Effects of becaplermin topical: A Synthesis of Findings from 27 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Major Research Findings

Becaplermin is a platelet-derived growth factor (PDGF) used to treat chronic wounds such as diabetic foot ulcers. Several studies have shown that becaplermin can accelerate wound healing. 27 , 25 , 18 , 24 Becaplermin is believed to promote wound healing by increasing proliferation and migration of various cells involved in the healing process. 27 Studies using animal models have shown that becaplermin can speed up wound healing. 19 , 18 However, there is also evidence suggesting that becaplermin may increase the risk of cancer. , 21 When using becaplermin, it is important to carefully consider the potential benefits and risks, including the risk of cancer.

Benefits and Risks

Benefit Summary

Becaplermin shows promise in accelerating the healing of chronic wounds, such as diabetic foot ulcers. 27 , 25 , 18 , 24 It promotes wound healing by stimulating the growth and movement of various cells involved in the healing process. 27 Animal models have demonstrated its effectiveness in speeding up wound closure. 19 , 18

Risk Summary

There is a potential risk of increased cancer development associated with becaplermin use. , 21 Therefore, a thorough evaluation of benefits and risks, including the risk of cancer, is crucial before using becaplermin.

Comparison Between Studies

Similarities

Numerous studies indicate that becaplermin promotes wound healing. 27 , 25 , 18 , 24 , 19 Becaplermin achieves this by stimulating the growth and migration of various cells involved in the healing process. 27

Differences

The effectiveness of becaplermin in promoting wound healing may vary depending on the type and model of the wound. For example, while animal models have shown becaplermin to accelerate wound healing, a study using diabetic mice did not observe a positive effect on wound healing. 17 Additionally, the level of risk associated with becaplermin and cancer development differs across studies. , 21

Consistency and Contradictions in Results

While becaplermin shows promise in promoting wound healing, there is also a potential risk of increased cancer development. , 21 The effectiveness of becaplermin in promoting wound healing can vary depending on the type and model of the wound. 17 Further research is needed to clarify these factors and their impact on treatment outcomes.

Considerations for Practical Application

Becaplermin is a potential treatment option for chronic wounds such as diabetic foot ulcers. 27 , 25 , 18 , 24 However, it is crucial to weigh the benefits against the risks, including the potential for increased cancer risk, before using becaplermin. , 21

Limitations of Current Research

While various studies have investigated the effects of becaplermin, the effectiveness of becaplermin can vary depending on the type and model of the wound. 17 Furthermore, the level of risk associated with becaplermin and cancer development requires further clarification, as findings across studies differ. , 21

Future Research Directions

To gain a deeper understanding of becaplermin's effects, research utilizing a variety of wound models is necessary. 17 Additionally, large-scale epidemiological studies are needed to accurately assess the risk of cancer associated with becaplermin use. , 21

Conclusion

Becaplermin holds promise as a potential treatment for chronic wounds. 27 , 25 , 18 , 24 However, it is essential to be aware of the potential risk of cancer associated with its use. , 21 Before using becaplermin, a careful evaluation of the benefits and risks is crucial. More research is needed to better understand its effectiveness in different wound types and to accurately assess the cancer risk associated with its use. This information will help healthcare providers make informed decisions regarding its use.

Literature analysis of 27 papers
Positive Content
24
Neutral Content
0
Negative Content
3
Article Type
16
1
1
4
27
1.

Effects of beta-adrenoceptors blocking eye drops in patients with chronic bronchitis.

Author: HuguesF C, MatteJ C, Le JeunneC, SalemA

Bronchoconstriction

Beta-blocker eyedrops, while effective for glaucoma, may enhance asthma symptoms. While most parameters were unchanged, forced expiratory volume in one second decreased in some patients, even with beta 1 selective blockers.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Changes in depressive status associated with topical beta-blockers.

Author: DuchS, DuchC, PastóL, FerrerP

Less depression
Depression risk

Betaxolol may be less likely than timolol to induce depression in predisposed patients. In a small study of glaucomatous patients, those treated with timolol had higher depression scores than those treated with betaxolol.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

The effects of time and dose on the relative beta 1- and beta 2-adrenoceptor antagonism of betaxolol and atenolol.

Author: LipworthB J, IrvineN A, McDevittD G

Beta 1-adrenoceptor blockade
Beta 2-adrenoceptor blockade
None mentioned

The study compared the effects of beta-blockers betaxolol and atenolol on heart rate and other measures in healthy subjects. Beta-blockers reduced exercise heart rate in a dose-dependent manner. Betaxolol was more selective for beta1 receptors, meaning it had a greater effect on the heart than on the lungs.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Assessment of systemic effects of different ophthalmic beta-blockers in healthy volunteers.

Author: BauerK, Brunner-FerberF, DistlerathL M, LippaE A, BinkowitzB, TillP, KaikG

Oculoselective
Safe for eyes
Systemic beta-blockade

The study examined the systemic beta-blockade caused by ophthalmic beta-blockers in healthy volunteers. All beta-blockers tested caused systemic beta-blockade, but betaxolol was less potent than metipranolol and timolol. Butapranolol, a noncardioselective but topically oculoselective drug, did not cause systemic beta-blockade.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Systemic effects of three beta-blocker eyedrops: comparison in healthy volunteers of beta 1- and beta 2-adrenoreceptor inhibition.

Author: Le JeunneC, MuneraY, HuguesF C

Effective beta-blocker
Good efficacy

Carteolol and timolol totally inhibited the beta 1 and beta 2 effects of isoproterenol, whereas betaxolol allowed the same effects with the same dose of isoproterenol.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

The significance of reactions to betaxolol reported by patients.

Author: BrooksA M, BurdenJ G, GilliesW E

Respiratory safety
Respiratory side effects

Betaxolol, an ocular hypotensive drug, was studied for its respiratory safety. Despite some patients reporting wheeze or respiratory distress, no changes in respiratory function were observed with betaxolol in a double-masked clinical study.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

[Comparison of the effect of a selective and a nonselective beta receptor blocker on the ischemic ST segment, lung function and stress-induced decrease in blood glucose].

Author: BrügmannU, BlasiniR

Effective for angina pectoris
Less effect on pulmonary function
Decrease in blood glucose

Betaxolol, a cardioselective beta-blocking agent, was as effective as nadolol, a non-selective agent, in reducing ST-segment depression in patients with stable exercise angina pectoris.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

8.

[Comparative pharmacoclinical study of 2 beta-blockers: atenolol and betaxolol in slight-to-moderate arterial hypertension].

Author: HerpinD, BoutaudP, CiberM A, AmielA, DemangeJ

Prolonged effects
Reduced blood pressure

Betaxolol was shown to have a more prolonged antihypertensive effect on exercising heart rate and blood pressure compared to atenolol, suggesting its potential for treating hypertension associated with physical activity.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : French

9.

Betaxolol vs timolol. A six-month double-blind comparison.

Author: StewartR H, KimbroughR L, WardR L

Cardiopulmonary safety
Glaucoma treatment

Betaxolol hydrochloride (0.5%) and timolol maleate (0.5%) were compared in a six-month study of 29 patients with glaucoma. Both drugs were effective in lowering intraocular pressure, with betaxolol reducing pressure by 7.6 mm Hg (26%) and timolol reducing pressure by 8.4 mm Hg (29%). Ocular side effects were mild and similar for both treatments.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Beta-adrenoceptor blocking effects and pharmacokinetics of betaxolol (SL 75212) in man.

Author: GiudicelliJ F, ChauvinM, ThuillezC, RicherC, BianchettiG, GomeniR, MorselliP L

Long-lasting effect
Potent beta-blocker

Betaxolol was a potent and long-lasting beta-adrenoceptor blocker, more potent than propranolol. It had a long duration of action and a long plasma elimination half-life.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

Observation on the efficacy and pharmacokinetics of betaxolol (SL 75212), a cardioselective beta-adrenoceptor blocking drug.

Author: BalnaveK, NeillJ D, RussellC J, HarronD W, LeaheyW J, WilsonR, ShanksR G

Long duration of effect
Tachycardia reduction

Betaxolol significantly reduced exercise tachycardia with a longer duration of action than other beta-blockers. It had a long plasma elimination half-life.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

12.

Betaxolol and timolol. A comparison of efficacy and side effects.

Author: BerryD P, Van BuskirkE M, ShieldsM B

Lower intraocular pressure
Selective beta 1-blockade

Betaxolol and timolol were comparable in efficacy and side effects for treatment of open-angle glaucoma.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

13.

The favorable effect of topical betaxolol and timolol on glaucomatous visual fields: a 2-year follow-up study.

Author: Vainio-JylhäE, VuoriM L

Visual Field Protection

A randomized, double-blind study comparing the effects of betaxolol and timolol on visual fields in glaucoma patients did not find significant differences.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

14.

Betaxolol versus carvedilol in chronic heart failure (BETACAR study). Rationale and design.

Author: BöhlerS, SaubaduS, ScheldewaertR, FigullaH R

Slows down progression of left ventricular dilatation

Beta-blockers were previously thought to be contraindicated in heart failure due to their negative inotropic effects. However, there is growing evidence that beta-blockers may slow down the progression of heart failure. BETACAR is a comparative study investigating the benefits of beta-blockade with betaxolol versus carvedilol in chronic heart failure.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

15.

Cost-Effectiveness of Becaplermin Gel on Diabetic Foot Ulcer HealingChanges in Wound Surface Area.

Author: WaycasterCurtis R, GilliganAdrienne M, MotleyTravis A

DFU treatment improvement

This study aims to compare the cost-effectiveness of becaplermin plus good wound care versus good wound care alone in treating diabetic foot ulcers. The study aims to inform healthcare decisions regarding the best treatment approach for DFUs, which pose a significant economic burden.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

16.

Growth factors for treating diabetic foot ulcers.

Author: Martí-CarvajalArturo J, GluudChristian, NicolaSusana, Simancas-RacinesDaniel, ReveizLudovic, OlivaPatricio, Cedeño-TabordaJorge

Complete wound healing
Adverse events

A Cochrane systematic review of 28 randomized clinical trials involving 2365 participants with diabetic foot ulcers found that growth factors may increase the likelihood of complete wound healing compared to placebo or no growth factor. However, the conclusion is based on trials with a high risk of systematic error and further trials are needed to draw firm conclusions. The safety profiles of the growth factors are unclear.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

17.

PDGF-BB does not accelerate healing in diabetic mice with splinted skin wounds.

Author: ParkShin Ae, RaghunathanVijay Krishna, ShahNihar M, TeixeiraLeandro, MottaMonica J, CovertJill, DubielzigRichard, SchurrMichael, IsseroffRoslyn Rivkah, AbbottNicholas L, McAnultyJonathan, MurphyChristopher J

Wound healing
PDGF-BB ineffectiveness

This study investigated the effect of topically applied platelet-derived growth factor-BB (PDGF-BB) on wound healing in db/db mice. PDGF-BB, although bioactive in vitro, failed to accelerate wound healing in vivo in the db/db mice using a splinted wound model.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

18.

Commercially available topical platelet-derived growth factor as a novel agent to accelerate burn-related wound healing.

Author: TravisTaryn E, MauskarNeil A, MinoMatthew J, PrindezeNick, MoffattLauren T, FidlerPhilip E, JordanMarion H, ShuppJeffrey W

Wound healing

Topical platelet-derived growth factor (PDGF) was shown to speed up epithelialization of partial-thickness wounds in a porcine model, as evidenced by improved histology, clinical appearance, and vascularity.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

19.

Topical application of recombinant platelet-derived growth factor increases the rate of healing and the level of proteins that regulate this response.

Author: GowdaSantosh, WeinsteinDavid A, BlalockTimothy D, GandhiKavita, MastBruce A, ChinGloria, SchultzGregory S

Accelerated wound healing

Platelet-derived growth factor (PDGF) accelerated wound healing in both normal and ischemic wounds in rats, suggesting its potential in promoting wound healing in conditions like ischemia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

20.

A fragment of secreted Hsp90α carries properties that enable it to accelerate effectively both acute and diabetic wound healing in mice.

Author: ChengChieh-Fang, SahuDivya, TsenFred, ZhaoZhengwei, FanJianhua, KimRosie, WangXinyi, O'BrienKathryn, LiYong, KuangYuting, ChenMei, WoodleyDavid T, LiWei

Diabetic wound healing
Wound healing efficacy

A 115-aa fragment of secreted Hsp90α promoted wound closure more effectively than PDGF-BB in both acute and diabetic wounds.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

21.

A matched cohort study of the risk of cancer in users of becaplermin.

Author: ZiyadehNajat, FifeDaniel, WalkerAlexander M, WilkinsonGregg S, SeegerJohn D

Cancer risk

This study investigated the association between becaplermin use and cancer risk in a large cohort of patients in a clinical practice setting. The results showed a relative risk of cancer of 2.8 in becaplermin users compared with placebo users. However, the 95% confidence interval was wide, suggesting that further studies are needed to confirm this finding.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

22.

Advanced biological therapies for diabetic foot ulcers.

Author: KirsnerRobert S, WarrinerRobert, MichelaMichelle, StasikLaure, FreemanKatherine

Improved healing
Larger wound area
Longer duration

Advanced biological therapies, including engineered skin, topical recombinant growth factor, and platelet releasate, improved healing of refractory diabetic foot ulcers. Larger wound area, more severe grades, and longer time to treatment were associated with longer time to healing.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

23.

Diabetic foot ulcers treated with becaplermin and TheraGauze, a moisture-controlling smart dressing: a randomized, multicenter, prospective analysis.

Author: LandsmanAdam, AgnewPatrick, ParishLawrence, JosephRobert, GalianoRobert D

Faster wound closure

This study evaluated the effectiveness of TheraGauze, a new polymer-impregnated dressing, in regulating moisture and promoting wound healing. The researchers found that TheraGauze was effective in regulating moisture and promoting faster wound closure.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

24.

Treatment of nonhealing diabetic foot ulcers with a platelet-derived growth factor gene-activated matrix (GAM501): results of a phase 1/2 trial.

Author: MulderGerit, TallisArthur J, MarshallV Tracy, MozingoDavid, PhillipsLaurie, PierceGlenn F, ChandlerLois A, SosnowskiBarbara K

Diabetic Foot Ulcer Treatment

This Phase 1/2 study evaluated the safety and efficacy of GAM501, a replication-defective adenovirus encoding human platelet-derived growth factor (PDGF)-B formulated in a bovine collagen gel, for nonhealing neuropathic diabetic foot ulcers. The study found that GAM501 was safe and well-tolerated, with ulcer closure observed in a majority of patients.

Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

25.

Clinical evaluation of recombinant human platelet-derived growth factor for the treatment of lower extremity ulcers.

Author: SteedDavid L

Increased healing
Reduced time to complete healing
Similar adverse events

Platelet-derived growth factor (PDGF) applied once daily was effective in healing chronic diabetic neurotrophic foot ulcers when used in conjunction with good wound care.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

26.

The cost-effectiveness of treating diabetic lower extremity ulcers with becaplermin (Regranex): a core model with an application using Swedish cost data.

Author: PerssonU, WillisM, OdegaardK, ApelqvistJ

Cost effective
Increased healing
Reduced amputations

Treatment with becaplermin in conjunction with GWC consumes fewer resources and generates better outcomes than treatment with GWC alone for diabetic neuropathic ulcers.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

27.

[Becaplermin gel (Regranex gel)].

Author: SenetP

Accelerated wound healing

This article describes becaplermine gel (Regranex), a topical medication used to promote wound healing. It contains a growth factor called PDGF-BB, which stimulates the growth of skin cells and improves healing in patients with diabetic ulcers and other wounds. It is a safe and effective treatment with minimal side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : French

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.