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Nifedipine versus terbutaline, tocolytic effectiveness and maternal and neonatal adverse effects: a randomized, controlled pilot trial.

Author: GuyattGordon, LopesLuciane Cruz, PadovaniTania Regina

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This randomized controlled trial compared the effects of terbutaline and nifedipine on inhibition of uterine contractions, preterm birth, and maternal and neonatal adverse reactions in women in preterm labour. Both drugs performed similarly in their tocolytic effects, but nifedipine was associated with fewer adverse effects.
Paper Details　
Original Abstract of the Article :
Although previous evidence suggests advantages of nifedipine over terbutaline as tocolytic agents, in some jurisdictions, terbutaline is approved for use and nifedipine is not. In women in preterm labour, we compared the impact of terbutaline versus nifedipine on inhibition of uterine contractions, ...See full text at original site
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引用元：
https://doi.org/10.1111/bcpt.12306

データ提供：米国国立医学図書館（NLM）

Tocolytic Therapy: A Comparison of Nifedipine and Terbutaline

The field of obstetrics is constantly seeking effective and safe treatments for preterm labor. This randomized controlled pilot trial compares the efficacy and safety of nifedipine and terbutaline as tocolytic agents in women experiencing preterm labor. The researchers found no significant difference between the two groups in terms of tocolysis or preterm birth. However, they observed a greater incidence of side effects with terbutaline, suggesting a potential advantage for nifedipine in terms of overall tolerability.

Nifedipine: A Potential Tocolytic Option with Fewer Side Effects

The study's findings suggest that nifedipine may be a viable tocolytic option with a favorable side effect profile compared to terbutaline. This information could guide clinical decision-making and potentially enhance the safety and well-being of women experiencing preterm labor.

Navigating the Desert of Preterm Labor

This study offers valuable insights into the tocolytic properties of nifedipine and terbutaline. The research provides a roadmap for clinicians navigating the complex terrain of preterm labor, highlighting the potential advantages of nifedipine in terms of tolerability and side effects.

Dr.Camel's Conclusion

This study suggests that nifedipine may be a viable tocolytic option with a more favorable side effect profile compared to terbutaline. This information could guide clinical decision-making and potentially enhance the safety and well-being of women experiencing preterm labor, providing a potential oasis in the desert of preterm labor management.

Date :
  1. Date Completed 2015-11-03
  2. Date Revised 2015-02-16
Further Info :

Pubmed ID

25146233

DOI: Digital Object Identifier

10.1111/bcpt.12306

Related Literature

Article Analysis
・Side Effects of terbutaline
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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