Side Effects of terbutaline: A Synthesis of Findings from 15 Studies

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Original Abstract of the Article

Main research findings

Terbutaline is a bronchodilator used to treat asthma. Several studies have been conducted on the side effects of terbutaline. 4 reported that infusion of terbutaline sulfate (0.25 mg) was followed by increases in plasma insulin and blood glucose concentrations and by a decrease in plasma potassium. Similar metabolic changes were observed on the first day of oral terbutaline administration (5 mg, 3 times daily). 13 reported a case of stuttering priapism treated with salbutamol, a beta-2 agonist similar to terbutaline. 3 reviewed five years of experience using terbutaline for preterm labor and found a low rate of severe side effects. These findings suggest that terbutaline is an effective bronchodilator, but there is a risk of side effects.

Reasons for side effects

Side effects of terbutaline are thought to be caused by its action on beta-2 adrenergic receptors. Terbutaline works by acting on beta-2 adrenergic receptors in bronchial smooth muscle to cause bronchodilation, but it can also act on beta-2 adrenergic receptors in the heart and other tissues, leading to side effects. 11 suggests that terbutaline may interact with cell membrane models, which may affect its pharmacological activity.

Common side effects

Tremors

One of the most common side effects of terbutaline is tremors. 4 reported that hand tremor always increased after terbutaline, but to a lesser degree on days 5 and 13 than after the first oral dose. 1 compared terbutaline, salbutamol, and fenoterol and found that salbutamol caused the most intense tremors. 2 suggests that reducing the inhaled dose of terbutaline may reduce tremors.

Heart palpitations

Terbutaline can act on beta-2 adrenergic receptors in the heart to increase heart rate. 4 reported that heart rate was moderately increased by terbutaline over the entire period of oral dosing. 1 found that salbutamol and fenoterol caused an increase in heart rate, while terbutaline caused a slight decrease. compared terbutaline and fenoterol and found that fenoterol caused a significantly greater increase in heart rate than terbutaline.

Nausea

Terbutaline can cause nausea. 3 reported that some patients experienced nausea after terbutaline administration. lists nausea as a long-term side effect of terbutaline.

Dizziness

Terbutaline can cause dizziness. lists dizziness as a long-term side effect of terbutaline.

Headache

Terbutaline can cause headaches. lists headaches as a long-term side effect of terbutaline.

Flushing

Terbutaline can cause flushing. lists flushing as a long-term side effect of terbutaline.

Increased blood sugar

Terbutaline can cause an increase in blood sugar levels. 4 reported an increase in blood glucose levels after terbutaline administration.

Decreased blood potassium

Terbutaline can cause a decrease in blood potassium levels. 4 reported a decrease in plasma potassium levels after terbutaline administration.

Other

Terbutaline can cause other side effects. 9 reported a case of focal seizures after terbutaline sulfate syrup. 14 reported psychiatric disorders, respiratory, thoracic, and mediastinal disorders, and skin and subcutaneous disorders as adverse drug reactions associated with asthma medications.

Side effect management

Tremors

Tremors caused by terbutaline usually subside when treatment is discontinued. 4 reported that tremors always increased after terbutaline but were less severe on days 5 and 13 than after the first oral dose.

Heart palpitations

Heart palpitations caused by terbutaline usually subside when treatment is discontinued. 1 found that terbutaline caused less severe palpitations compared to salbutamol and fenoterol.

Nausea

Nausea caused by terbutaline usually subsides when treatment is discontinued. 3 reported that terbutaline caused nausea in some patients but there were few serious side effects. Reducing the dose of terbutaline, taking it before meals, or other methods may help reduce nausea.

Dizziness

Dizziness caused by terbutaline usually subsides when treatment is discontinued. If dizziness is severe, consult your doctor.

Headache

Headaches caused by terbutaline usually subside when treatment is discontinued. If headaches are severe, consult your doctor.

Flushing

Flushing caused by terbutaline usually subsides when treatment is discontinued. If flushing is severe, consult your doctor.

Increased blood sugar

Increased blood sugar levels caused by terbutaline should be monitored carefully in patients with diabetes. Patients with diabetes should consult their doctor for blood sugar management.

Decreased blood potassium

Decreased blood potassium levels caused by terbutaline should be monitored carefully in patients with heart disease. Patients with heart disease should consult their doctor for blood potassium management.

Comparison of studies

Similarities between studies

Many studies have found similar results regarding the side effects of terbutaline. For example, many studies have reported that tremors, palpitations, nausea, dizziness, and headaches are common side effects after terbutaline administration. Terbutaline can also act on beta-2 adrenergic receptors in the heart and other tissues, leading to side effects.

Differences between studies

The severity and frequency of terbutaline side effects vary depending on the study. For example, 4 reported that tremors always increased after terbutaline, but were less severe on days 5 and 13 than after the first oral dose. On the other hand, 1 found that salbutamol caused the most intense tremors. The severity and frequency of terbutaline side effects may vary depending on the individual patient and the method of administration.

Considerations for real-world application

While terbutaline is an effective bronchodilator, it is important to be aware of the potential side effects. When taking terbutaline, it is important to consult with your doctor and understand the risks and benefits of taking the medication. If you experience any side effects such as tremors, palpitations, nausea, dizziness, headaches, or any other side effects while taking terbutaline, consult your doctor.

Limitations of current research

Research on the side effects of terbutaline is still ongoing. More research is needed, especially on long-term side effects and side effects in specific patient populations. provides some findings on long-term side effects of terbutaline but further long-term studies are needed. The mechanisms behind terbutaline side effects are not fully understood. 11 suggests that terbutaline may interact with cell membrane models, but further research is needed.

Future research directions

Future research on terbutaline side effects should focus on long-term side effects, side effects in specific patient populations, and the mechanisms behind side effects. Development of new treatments to reduce terbutaline side effects is also important.

Conclusion

Terbutaline is an effective bronchodilator but carries a risk of side effects. Consult with your doctor before taking terbutaline to understand the risks and benefits of the medication. If you experience any side effects while taking terbutaline, consult your doctor.

Literature analysis of 15 papers
Positive Content
12
Neutral Content
0
Negative Content
3
Article Type
4
0
0
2
14
1.

Efficacy and side effects of beta 2-agonists by inhaled route in acute asthma in children: comparison of salbutamol, terbutaline, and fenoterol.

Author: ScalabrinD M, SoléD, NaspitzC K

Effective bronchodilation
Tachycardia
Tremor

Salbutamol, terbutaline, and fenoterol were equally effective in treating acute bronchospasm in children, but salbutamol was associated with more intense tremor and tachycardia.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

2.

Effects, side effects and plasma concentrations of terbutaline in adult asthmatics after inhaling from a dry powder inhaler device at different inhalation flows and volumes.

Author: EngelT, ScharlingB, SkovstedB, HeinigJ H

Asthma treatment
Reduced efficacy
Side effects

The Turbohaler, a dry powder inhaler device for terbutaline sulfate and budesonide, achieves maximum bronchodilation within 5 minutes after inhalation. Different inspiratory flows through the device (34-88 L/min) result in comparable bronchodilation, while exhaling before inhalation reduces the effect. Reducing inspiratory flow to 34 L/min slightly decreases side effects and plasma terbutaline concentrations.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

A comparative double-blind study of the bronchodilator effects and side effects of inhaled fenoterol and terbutaline administered in equipotent doses.

Author: GrayB J, FrameM H, CostelloJ F

Asthma treatment
Cardiac effects

Fenoterol (100 microgram) was equal in potency to terbutaline (250 microgram) for bronchodilation, but caused significantly more cardiac effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

[The bronchospasmolytics salbutamol, fenoterol, terbutaline and reproterol. Their effects and side effects in asthmatics after inhalation with an electric nebulizer].

Author: BudmigerH, KydK, ScherrerM

Bronchodilator
Hypocapnia
Hypoxemia
Tachycardia

Salbutamol was found to be the most selective beta-stimulator for asthma, followed by fenoterol, terbutaline, and reproterol.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

7.

Aerosolized terbutaline sulfate--an evalution of efficacy and side effects in patients with reversible airway disease.

Author: TrautleinJ, AllegraJ, GillinM

Effective for asthma
Long-acting
Sympathomimetic side effects

Aerosolized terbutaline sulfate was effective in treating reversible airway disease in patients with chronic obstructive pulmonary disease. There was a statistically significant increase in FEV1.0 and MMEFR. Sympathomimetic side effects were observed.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

9.

Focal Seizures in a Child Receiving Terbutaline Sulfate: A Case Report.

Author: NadeemFalah, AliMaria, HameedNida

Focal seizures

This report describes a case of a five-month-old girl who experienced seizures after taking terbutaline sulfate, a medication used to treat asthma. While seizures are not a common side effect of terbutaline sulfate, this case highlights the importance of considering drug-related adverse effects in children with new-onset seizures.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

12.

Advances in the treatment of mild asthma: recent evidence.

Author: O'ByrnePaul M, MejzaFilip

Asthma control
Reduced exacerbations
ICS side effects

This study reviewed the results of two large double-blind randomized trials assessing the use of as-needed budesonide/formoterol in patients with mild asthma. The study found that as-needed budesonide/formoterol therapy has acceptable efficacy in mild asthma and may be viewed as a therapeutic option for these patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

13.

Idiopathic stuttering priapism treated with salbutamol orally: a case report.

Author: MiglioriniF, PorcaroA B, BaldassarreR, ArtibaniW

Stuttering priapism treatment
Hypogonadal state
Infertility

Salbutamol, a beta-2-agonist, was effective in treating a case of stuttering priapism, a rare form of ischaemic priapism.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

15.

Nifedipine versus terbutaline, tocolytic effectiveness and maternal and neonatal adverse effects: a randomized, controlled pilot trial.

Author: PadovaniTania Regina, GuyattGordon, LopesLuciane Cruz

Preterm birth prevention
Tocolysis
Dizziness
Flushing
Headache
Nausea
Tremor

This randomized controlled trial compared the effects of terbutaline and nifedipine on inhibition of uterine contractions, preterm birth, and maternal and neonatal adverse reactions in women in preterm labour. Both drugs performed similarly in their tocolytic effects, but nifedipine was associated with fewer adverse effects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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