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Naloxegol for the treatment of opioid-induced constipation.

Author: CorsettiMaura, TackJan

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This drug profile summarizes published information on the effects of naloxegol, a peripherally-acting µ-opioid receptor antagonist, in opioid-induced constipation (OIC). Naloxegol was effective in inhibiting OIC without signs of opioid withdrawal. Side effects were mainly gastrointestinal in origin and usually transient and mild.
Paper Details　
Original Abstract of the Article :
With increasing chronic opioid use, opioid-induced constipation (OIC) is a rapidly increasing clinical challenge. Naloxegol, an orally administered, peripherally-acting, µ-opioid receptor antagonist, was developed for the treatment of OIC. This drug profile summarizes published information and prese...See full text at original site
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引用元：
https://doi.org/10.1586/17474124.2014.939629

データ提供：米国国立医学図書館（NLM）

Tackling the Opioid-Induced Constipation Challenge

The field of [Gastrointestinal Pharmacology] is constantly evolving, with new challenges emerging regularly. One such challenge is [Opioid-Induced Constipation (OIC)], a common side effect of chronic opioid use. This study delves into the development of [Naloxegol], a novel medication designed to combat this issue. The researchers employed [Pharmacological and Clinical Trial] methodologies to investigate the efficacy and safety of Naloxegol. They discovered that [Naloxegol effectively reduced constipation symptoms without interfering with the analgesic effects of opioids]. This finding holds significant promise for patients suffering from OIC. Notably, [Naloxegol demonstrated a favorable safety profile with minimal side effects].

A Ray of Hope for Opioid Users

This research offers a glimmer of hope for individuals struggling with the debilitating effects of OIC. The study suggests that [Naloxegol represents a viable treatment option with the potential to significantly improve the quality of life for opioid users]. The effectiveness of Naloxegol, coupled with its relatively low risk of side effects, makes it a valuable addition to the therapeutic arsenal for managing OIC.

Navigating the Desert of Constipation

The desert of constipation can be a challenging and uncomfortable place to navigate. This study provides a refreshing oasis in the form of Naloxegol, offering a potential solution for those struggling with OIC. By understanding the mechanisms of Naloxegol, we can better equip ourselves to manage this condition and improve the well-being of individuals who rely on opioids for pain management.

Dr. Camel's Conclusion

Naloxegol offers a beacon of hope in the desert of opioid-induced constipation, paving the way for a more comfortable and fulfilling life for those affected by this condition. It's a testament to the ongoing efforts of researchers to address the complex challenges associated with opioid use.

Date :
  1. Date Completed 2015-06-15
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

25220391

DOI: Digital Object Identifier

10.1586/17474124.2014.939629

Related Literature

Article Analysis
・Side Effects of naloxegol
SNS
PICO Info
in preparation
Languages

English

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