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Are cannabidiol and Δ(9) -tetrahydrocannabivarin negative modulators of the endocannabinoid system? A systematic review.

Author: Di MarzoVincenzo, DuncanMarnie, McPartlandJohn M, PertweeRoger G

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This review article examines the pharmacological mechanisms of cannabidiol (CBD) and Δ(9) -tetrahydrocannabivarin (THCV), two cannabinoids found in cannabis. The article challenges the view that CBD and THCV behave like rimonabant, a CB1 receptor inverse agonist, and instead presents evidence suggesting that they have distinct pharmacological profiles.
Paper Details　
Original Abstract of the Article :
Based upon evidence that the therapeutic properties of Cannabis preparations are not solely dependent upon the presence of Δ(9) -tetrahydrocannabinol (THC), pharmacological studies have been recently carried out with other plant cannabinoids (phytocannabinoids), particularly cannabidiol (CBD) and Δ(...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301686/

データ提供：米国国立医学図書館（NLM）

The Effects of Cannabidiol (CBD) and Δ(9) -Tetrahydrocannabivarin (THCV) on the Endocannabinoid System

The world of cannabinoids is vast and fascinating, like a desert landscape stretching as far as the eye can see. In this research realm, we're exploring the therapeutic potential of cannabinoids beyond the well-known THC. This study uses a systematic review to analyze the effects of cannabidiol (CBD) and Δ(9) -tetrahydrocannabivarin (THCV) on the endocannabinoid system. The authors delved into in vitro and ex vivo studies, combining data in a meta-analysis to understand how CBD and THCV work within the body. They found that these cannabinoids differ significantly from the first-generation CB1 receptor inverse agonists like rimonabant, which are known to cause unwanted CNS effects.

CBD and THCV: A Journey Through the Endocannabinoid System

CBD and THCV are not simple carbon copies of each other in the intricate desert of the endocannabinoid system. CBD, though having a low affinity for CB1 receptors, can indirectly affect their activity, much like a gentle breeze whispering through a sand dune. On the other hand, THCV exhibits a high affinity for CB1 receptors, acting as a potent antagonist in vitro, but only occasionally displaying effects in vivo. THCV also has a special connection with CB2 receptors, acting as a partial agonist. These findings highlight the complex interplay between cannabinoids and the endocannabinoid system.

Understanding the Sand Dunes of the Endocannabinoid System

This study provides a much-needed compass to navigate the complexities of the endocannabinoid system. CBD and THCV, unlike their first-generation counterparts, seem to avoid the unwanted effects of rimonabant. These cannabinoids have unique profiles within the endocannabinoid system, showcasing the importance of in vivo research in understanding their potential therapeutic effects. Just like a desert explorer needs to carefully study the terrain, we must understand the interactions between these cannabinoids and the body to fully harness their benefits.

Dr. Camel's Conclusion

This study sheds light on the complex and nuanced interactions between cannabinoids and the endocannabinoid system. Like a desert oasis offering respite from the heat, CBD and THCV may offer a new path for therapeutic intervention. Their distinct profiles highlight the importance of rigorous in vivo research to truly understand the potential of these cannabinoids for human health.

Date :
  1. Date Completed 2015-11-02
  2. Date Revised 2022-03-18
Further Info :

Pubmed ID

25257544

DOI: Digital Object Identifier

PMC4301686

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SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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