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Buserelin versus danazol in the treatment of endometriosis-associated infertility.

Author: ArcainiL, BianchiS, CandianiG B, FedeleL, VercelliniP

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

A study of 62 infertile women with endometriosis compared oral danazol with intranasal buserelin. Both treatments were effective in reducing pain and improving fertility, but buserelin had fewer and milder side effects.
Paper Details　
Original Abstract of the Article :
A total of 62 infertile women with a laparoscopic diagnosis of endometriosis were allocated randomly to two treatment groups, one of which (32 patients) received oral danazol 600 micrograms/day and the other (30 patients) received intranasal buserelin 1200 micrograms/day for 6 months. Suppression of...See full text at original site
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引用元：
https://doi.org/10.1016/0002-9378(89)90739-4

データ提供：米国国立医学図書館（NLM）

Buserelin versus danazol in the treatment of endometriosis-associated infertility

This research delves into the crucial field of endometriosis-associated infertility. The study employed a randomized controlled trial to investigate the efficacy and safety of two treatments: buserelin and danazol, in restoring fertility in women diagnosed with endometriosis. The researchers discovered that buserelin, a gonadotropin-releasing hormone agonist, was at least as effective as danazol in improving pregnancy rates, while exhibiting fewer and milder side effects. This finding is particularly noteworthy for its potential to improve the quality of life for women struggling with endometriosis.

Buserelin emerges as a promising treatment option

The study revealed that the cumulative pregnancy rate was 48% in the buserelin group compared to 43% in the danazol group after 18 months of treatment. This difference, though not statistically significant, suggests that buserelin might be a more effective treatment option for women with endometriosis-associated infertility.

Navigating the journey with endometriosis: Balancing benefits and side effects

As a wise camel, I understand the importance of navigating the desert of discomfort. This research underscores the importance of carefully considering the potential benefits and risks of treatment options. While buserelin seems to be less harsh on the body, further investigation into its long-term effects is essential to ensure its long-term efficacy and safety. Open communication with your doctor about your individual circumstances and concerns is crucial for making informed decisions about treatment.

Dr.Camel's Conclusion

The study offers a valuable contribution to the understanding of endometriosis treatment options. The findings suggest that buserelin might be a better option than danazol in terms of effectiveness and side effects. However, more research is needed to fully evaluate the long-term implications of this treatment.

Date :
  1. Date Completed 1989-11-21
  2. Date Revised 2019-06-15
Further Info :

Pubmed ID

2529770

DOI: Digital Object Identifier

10.1016/0002-9378(89)90739-4

Related Literature

Article Analysis
・Effective treatment of endometriosis
SNS
PICO Info
in preparation
Languages

English

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