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Efficacy and tolerability of histamine-2 receptor antagonist adjunction of antipsychotic treatment in schizophrenia: a meta-analysis of randomized placebo-controlled trials.

Author: IwataN, KishiT

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Overview

This meta-analysis of 8 randomized controlled trials (n=418) investigating the efficacy of histamine-2 receptor antagonists (H2R-ANTs) as adjunctive therapy for schizophrenia found no significant improvement in overall symptoms. However, H2R-ANTs resulted in lower body mass index (BMI) compared to placebo. Nizatidine was associated with an increase in plasma leptin levels and a higher incidence of depression and dry mouth.
Paper Details　
Original Abstract of the Article :
INTRODUCTION: No comprehensive meta-analysis has been performed concerning the efficacy and tolerability of adjunctive therapy with histamine-2 receptor antagonists (H2R-ANTs) in schizophrenia patients who were treated with antipsychotics. METHODS: Risk ratios, standardized mean differences (SMD), ...See full text at original site
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引用元：
https://doi.org/10.1055/s-0034-1390478

データ提供：米国国立医学図書館（NLM）

Histamine-2 Receptor Antagonists: A New Frontier in Schizophrenia Treatment?

Schizophrenia, a complex brain disorder, presents numerous challenges in treatment. This study, published in the journal Schizophrenia Research, delves into the potential benefits of histamine-2 receptor antagonists (H2R-ANTs) as adjunctive therapy for schizophrenia patients. The researchers meticulously analyzed data from multiple randomized controlled trials to assess the efficacy and tolerability of these medications.

The Results: A Mixed Bag

The study found that H2R-ANTs, when added to existing antipsychotic treatment, did not significantly improve overall symptoms in schizophrenia patients. However, they did observe a reduction in body mass index (BMI) in patients treated with H2R-ANTs compared to placebo. The authors also noted that nizatidine, a specific H2R-ANT, was associated with increased plasma leptin levels and a higher incidence of side effects like depression and dry mouth. The results suggest that while H2R-ANTs may offer some benefits, further research is needed to clarify their optimal role in schizophrenia treatment.

Potential Benefits and Considerations

The findings of this study suggest that H2R-ANTs may help manage weight gain, a common side effect of antipsychotic medications. However, the increased risk of side effects associated with nizatidine underscores the need for careful monitoring and individual patient assessment. As always, it is crucial to discuss any potential treatment options with your healthcare provider to determine the best course of action for your specific needs.

Dr.Camel's Conclusion

While H2R-ANTs may not be a silver bullet for schizophrenia treatment, this research provides valuable insights into their potential benefits and risks. It reminds us that the journey to effective treatment often requires a nuanced approach, carefully considering individual patient factors and the potential benefits and drawbacks of various therapies.

Date :
  1. Date Completed 2015-09-01
  2. Date Revised 2015-01-10
Further Info :

Pubmed ID

25321187

DOI: Digital Object Identifier

10.1055/s-0034-1390478

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SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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