Side Effects of nizatidine: A Synthesis of Findings from 19 Studies

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Original Abstract of the Article

Major Findings

Nizatidine is an H2-receptor antagonist used to treat peptic ulcers. Several studies have shown that nizatidine is as effective as ranitidine, another H2-receptor antagonist, in treating peptic ulcers. 2 , 4 , 12 . Nizatidine has also been shown to suppress nocturnal acid secretion, which may help to speed up the healing of gastric ulcers. 16 , 12 . Nizatidine has the added benefit of not interfering with the hepatic metabolism of other drugs. 6 . Nizatidine is also safe for use in elderly patients or patients with impaired kidney function. 6 . However, the dosage should be reduced in patients with impaired renal function. 6 .

Reasons for Side Effects

The side effects of nizatidine are mainly due to the suppression of gastric acid secretion. The suppression of gastric acid secretion can lead to an increase in the alkalinity of the stomach contents, which may promote the growth of bacteria in the stomach. The suppression of gastric acid secretion can also reduce the protective effects of the stomach. These factors may contribute to the side effects of nizatidine.

Common Side Effects

Headache

Nizatidine may cause headaches. 5 .

Diarrhea

Nizatidine may cause diarrhea. 5 .

Nausea

Nizatidine may cause nausea. 5 .

Constipation

Nizatidine may cause constipation. 5 .

Lower Respiratory Tract Infections

Immunocompromised infants and children, or those with indwelling catheters, may be at risk for lower respiratory tract infections and nosocomial sepsis if they are treated with gastric acid suppressants like nizatidine. 5 .

Side Effect Management

Headache

Consult a doctor if you experience severe headaches. You may also take pain relievers to help reduce headache pain.

Diarrhea

Consult a doctor if you experience severe diarrhea. You may also take medication to stop the diarrhea.

Nausea

Consult a doctor if you experience severe nausea. You may also take medication to stop the nausea.

Constipation

Consult a doctor if you experience severe constipation. You may also take medication to relieve constipation. It is also important to eat a diet high in fiber.

Lower Respiratory Tract Infections

Consult a doctor before taking nizatidine or other gastric acid suppressants if you are an immunocompromised infant or child, or have an indwelling catheter.

Comparison of Studies

Similarities

Numerous studies have shown that nizatidine is as effective as other H2-receptor antagonists. 2 , 4 , 12 . Many studies have also reported that nizatidine does not interfere with the hepatic metabolism of other drugs. 6 .

Differences

Several studies have found that nizatidine helps to speed up the healing of gastric ulcers. 16 , 12 . However, not all studies have confirmed this finding.

Real-World Application Considerations

Nizatidine is a medication used to treat peptic ulcers. Do not take it without consulting a doctor, and follow their instructions carefully. Be aware of the potential side effects of nizatidine, and consult a doctor if you have concerns.

Limitations of Current Research

There is still insufficient research on nizatidine, particularly regarding long-term safety. As a result, the risks associated with long-term nizatidine use are not yet fully understood.

Future Research Directions

Further research is needed to determine the long-term safety of nizatidine. Research is also needed to further investigate the effects of nizatidine on the healing of gastric ulcers.

Conclusion

Nizatidine is an effective treatment for peptic ulcers. However, it is important to be aware of the potential side effects. If you have concerns about side effects, consult a doctor. There is still insufficient research on the long-term safety of nizatidine. As a result, the risks associated with long-term nizatidine use are not yet fully understood. Future research is needed to determine the long-term safety of nizatidine.

Literature analysis of 19 papers
Positive Content
16
Neutral Content
2
Negative Content
1
Article Type
4
2
0
3
19
1.

A comparison of nizatidine and ranitidine in the maintenance treatment of duodenal ulcer. A randomized, double blind, multicentre, 2-year study.

Author: Di MarioF, BattagliaG, SaggioroA, ChiozziniP, D'AngeloA, MarinR, MorelliA, VezzadiniP, BuscariniL, CavassiniG

Prevention of duodenal ulcer relapse
N/A

A study comparing nizatidine and ranitidine for preventing duodenal ulcer relapse found no significant difference in efficacy between the two medications. Both treatments were well tolerated with no significant adverse effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

[Nizatidine].

Author: RomeroM, FranzosiM G

Duodenal ulcer treatment
Gastric ulcer treatment

Nizatidine is a new H2-receptor antagonist that is as potent as ranitidine. It does not interfere with hepatic metabolism and lacks anti-androgenic effects. A single evening dose of 300 mg effectively suppresses nocturnal acid secretion without carryover into the daytime. Clinical trials with nizatidine have shown comparable healing rates for duodenal and gastric ulcers, as well as reduction in relapse rates, compared to ranitidine. Nizatidine has been well tolerated with no unexpected or unwanted side effects reported in over 3800 patients.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : Italian

3.

Triple therapy for the eradication of Helicobacter pylori and reduction of duodenal ulcer relapse: comparison of 1 week and 2 week regimens and recrudescence rates over 12 months.

Author: ChenT S, TsayS H, ChangF Y, LeeS D

Helicobacter pylori treatment
Triple therapy effective

Helicobacter pylori infection was strongly associated with duodenal ulcer relapse. Triple therapy for 1 week or 2 weeks was significantly more effective than no treatment in preventing relapse. Ulcer relapse was significantly more frequent in patients with persistent H. pylori infection.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Nizatidine versus ranitidine in the treatment of peptic ulcer disease: report on the Dutch investigation as part of a European multicentre trial.

Author: KuipersE J, HazenbergH J, QuikR F, HazenbergB P, de ZwartP A

Heal duodenal ulcers
Heal gastric ulcers
Few side effects

Nizatidine, administered as a 300 mg nocte and as a 150 mg b.d. dose, was as effective as ranitidine in the treatment of duodenal and gastric ulceration.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

[Nizatidine: a meta-analytical study].

Author: di CiommoV, FerrarioF

Duodenal ulcer treatment
Nizatidine effective
Side effects

Nizatidine, an H2-antagonist, showed comparable therapeutic efficacy to other H2-antagonists in the treatment of duodenal ulcer disease. In a meta-analysis of randomized clinical trials, nizatidine demonstrated similar effectiveness to ranitidine in both acute and long-term treatments. However, nizatidine was associated with fewer side effects than ranitidine.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : Italian

8.

Comparison of omeprazole and nizatidine in the treatment of duodenal ulcers.

Author: PerngD S, ChenC Y, JanC M, WangW M, ChenL T

Heals duodenal ulcers
Relieves ulcer pain
Smoking decreases healing

Omeprazole was significantly more effective than nizatidine in healing duodenal ulcers after two weeks of treatment. Omeprazole relieved ulcer pain sooner than nizatidine. Smoking decreased the healing rate in the omeprazole group, but not in the nizatidine groups.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

9.

Gastroprotective effects of several H2RAs on ibuprofen-induced gastric ulcer in rats.

Author: LiuJing, SunDan, HeJinfeng, YangChengli, HuTingting, ZhangLijing, CaoHua, TongAi-Ping, SongXiangrong, XieYongmei, HeGu, GuoGang, LuoYoufu, ChengPing, ZhengYu

Gastric protection
Low toxicity

This study investigated the gastric protective effects of histamine-2 receptor antagonists (H2RAs) in combination with ibuprofen. Nizatidine showed the best protective effect without significant toxicity and is a good option for combination therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Clarithromycin, amoxycillin and H2-receptor antagonist therapy for Helicobacter pylori peptic ulcer disease in Korea.

Author: BreuerT, KimJ G, el-ZimaityH M, NakajimaS, OtaH, OsatoM, GrahamD Y, NikajimaS

Few side effects
H. pylori cure
Clarithromycin resistance

A 10-day twice-daily quadruple therapy with lansoprazole, tetracycline, metronidazole, and bismuth was effective for metronidazole-sensitive H. pylori infection, but less effective for resistant strains.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

12.

Nizatidine and ranitidine in the short-term treatment of duodenal ulcer: a cooperative double-blind study of once-daily bedtime administration.

Author: PaceF, ColomboE, FerraraA, PradaA, RoccaF, Bianchi PorroG

Pain relief
Safe treatment
Ulcer healing
Minor side effects

Nizatidine, a new H2-antagonist, was found to be as effective and safe as ranitidine in the short-term treatment of duodenal ulcer.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

13.

Intravenous nizatidine kinetics and acid suppression.

Author: CallaghanJ T, BergstromR F, ObermeyerB D, KingE P, OffenW W

Gastric acid suppression
Reduced acid output

Intravenous nizatidine effectively suppressed gastric acid secretion in a dose-dependent manner. Nizatidine (100 mg) was comparable to cimetidine (300 mg) in its suppressive effects. The drug demonstrated linear pharmacokinetics.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

14.

Options for pharmacological management of obesity in patients treated with atypical antipsychotics.

Author: WernekeU, TaylorD, SandersT A B

Weight gain

There is currently no strong evidence to support the use of pharmacological interventions for overweight patients treated with antipsychotic medication.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

16.

[Treatment of acute stomach ulcer with H2 receptor antagonists. A direct therapy comparison with 300 mg nizatidine nightly and 2 times 150 mg nizatidine with twice daily 150 mg ranitidine].

Author: ArnoldR, BeckenbachP, BockH, BormannR, BrunnerG, DaakeH, DammannH G, DietrichK, FuererM, GeiterB

Gastric ulcer treatment

This double-blind study in 242 patients with acute benign gastric ulcers found that a single 300 mg dose of nizatidine at bedtime effectively suppressed nocturnal gastric acid secretion and accelerated ulcer healing. The healing rates were comparable to those seen with twice-daily doses of nizatidine or ranitidine. No clinically relevant side effects were observed in any treatment group.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : German

17.

Evaluation of therapeutic regimens for the treatment of Helicobacter pylori infection.

Author: LeeD H, ParkH J, SongS Y, LeeS J, ChoiW, LeeY C, ChungJ B, KangJ K, ParkI S, LeeY H, KimH K

H. pylori eradication
Abdominal pain
Diarrhea
Dizziness
Nausea

Triple therapy with omeprazole, metronidazole, and amoxicillin was the most effective regimen for Helicobacter pylori eradication, achieving an eradication rate of 89.3%. The compliance of patients was good, and side effects were minimal.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

18.

Nizatidine: a new histamine receptor blocker in the treatment of active duodenal ulcers.

Author: LevendogluH, MehtaB, WaitC, ReddyG, HatcherC

Effective ulcer healing
Improved pain relief
Increased creatinine

Nizatidine, a histamine blocker, was significantly more effective than placebo in promoting healing of duodenal ulcers. It showed a high incidence of complete endoscopic healing and significant improvement in day pain relief after 8 weeks of treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

19.

Effect of nizatidine versus ranitidine on gastric intraluminal prostaglandin release in duodenal ulcer patients.

Author: SilecchiaG, SpazianiE, GuarinoE, NeriT, GrassoE, MarianiP, MateriaA, GencoA, BassoN

Peptic ulcer treatment

This study compared the effects of nizatidine and ranitidine on gastric mucosal prostanoid release in patients with duodenal ulcers. Nizatidine increased PGE2 levels, while ranitidine did not. Patients with Helicobacter pylori infection had lower prostanoid concentrations, but nizatidine was equally effective in increasing prostanoid levels in both groups.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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