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An attempt to alter the pathophysiology of polycystic ovary syndrome using a gonadotrophin hormone releasing hormone agonist--Nafarelin.

Author: BurfordG, ShawR W, WilliamsI A

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A study of 15 women with polycystic ovary syndrome found that the GnRH agonist Nafarelin effectively suppressed gonadotropins and androgens, but did not consistently reduce ovarian volume or improve hirsutism. The study suggests that the underlying condition remains permanent.
Paper Details　
Original Abstract of the Article :
The aim of this study was to see whether the pathophysiology of polycystic ovary syndrome could be altered by suppressing the abnormal cycle of events associated with abnormal gonadotrophins and androgens. Fifteen women with polycystic ovary syndrome were treated with the GnRH agonist Nafarelin at a...See full text at original site
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引用元：
https://doi.org/10.1111/j.1365-2265.1989.tb01258.x

データ提供：米国国立医学図書館（NLM）

Navigating the Hormonal Desert: A Study on Polycystic Ovary Syndrome

Polycystic ovary syndrome (PCOS) is a hormonal desert, a complex condition that disrupts the delicate balance of female hormones. This study takes a closer look at PCOS by exploring the potential of a gonadotrophin hormone-releasing hormone agonist (GnRH) called Nafarelin to alter its pathophysiology. The researchers conducted a study involving 15 women with PCOS, administering Nafarelin intranasally for 3 or 6 months. They carefully monitored hormone levels and ovarian changes using ultrasound. The findings revealed that while Nafarelin effectively suppressed gonadotropins and androgens, it did not lead to any significant changes in the ultrasound appearance of the ovaries or a consistent reduction in ovarian volume. While the hormonal suppression was successful, the study suggested that the underlying cause of PCOS may be more complex and enduring.

A New Trail in the Hormonal Desert: The Search for PCOS Solutions

This study adds valuable insights to the ongoing exploration of PCOS. While Nafarelin showed promise in suppressing hormone levels, it didn't address the fundamental aspects of the condition. This research underscores the need for further investigation into the intricate interplay of hormones in PCOS.

Understanding the Shifting Sands: Managing PCOS

PCOS is a complex condition that often requires a multifaceted approach. This study emphasizes the importance of seeking professional guidance for appropriate diagnosis and treatment. Remember, managing PCOS is like navigating a vast desert; it requires patience, persistence, and a collaborative approach with your healthcare provider.

Dr. Camel's Conclusion

PCOS is a challenging desert to traverse, but this study provides valuable insights into the intricacies of the condition. While Nafarelin didn't offer a complete solution, it highlights the importance of addressing hormone imbalances and underscores the need for continued exploration of new therapeutic avenues.

Date :
  1. Date Completed 1990-03-19
  2. Date Revised 2019-08-13
Further Info :

Pubmed ID

2533526

DOI: Digital Object Identifier

10.1111/j.1365-2265.1989.tb01258.x

Related Literature

Article Analysis
・Effective treatment of polycystic ovary syndrome
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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