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Effectiveness of switching to the rivastigmine transdermal patch from oral cholinesterase inhibitors: a naturalistic prospective study in Alzheimer's disease.

Author: , CagninAnnachiara, CesterAlberto, CostaBruno, ErmaniMario, GabelliCarlo, GambinaGiuseppe

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Donepezil and rivastigmine are medications used to treat Alzheimer's disease (AD). This study investigated the effects of switching from oral donepezil or rivastigmine to rivastigmine patches in patients with AD who did not respond to previous treatment. Results showed that switching to rivastigmine patches resulted in cognitive improvement in more than half of the patients.
Paper Details　
Original Abstract of the Article :
Oral donepezil and rivastigmine are two commonly used cholinesterase inhibitors (ChEIs) used in Alzheimer's disease (AD). The rivastigmine transdermal patch formulation has high tolerability profile, allowing patients to achieve optimal therapeutic doses and providing potential advantages over oral ...See full text at original site
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引用元：
https://doi.org/10.1007/s10072-014-2002-3

データ提供：米国国立医学図書館（NLM）

Switching Gears: Evaluating the Effectiveness of Rivastigmine Patches in Alzheimer's Disease

Alzheimer's disease (AD) is a complex and debilitating condition, much like navigating the treacherous sands of a desert storm. This study explores the effectiveness of switching from oral cholinesterase inhibitors (ChEIs) to rivastigmine patches in patients with AD who did not experience benefits from prior treatments.

A New Path for Alzheimer's Treatment

The study found that switching to rivastigmine patches was effective and safe in more than half of the patients after a 6-month period. The switch led to stabilization or improvement in cognitive function as measured by the mini-mental state examination (MMSE) test. The study also found that patients who experienced a lack of response to oral ChEIs showed significant improvement in cognitive decline after switching to the rivastigmine patch.

Hope on the Horizon for Alzheimer's Patients

This research provides hope for patients with AD who have not experienced benefits from oral ChEI therapy. The findings suggest that rivastigmine patches may offer a viable alternative, potentially improving cognitive function and reducing the need for oral medications.

Dr.Camel's Conclusion

The journey through Alzheimer's disease can be challenging. This study highlights the importance of exploring new treatment options and finding the right path for each individual. The findings suggest that rivastigmine patches could be a beacon of hope for patients seeking alternative therapies.

Date :
  1. Date Completed 2016-01-15
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

25394739

DOI: Digital Object Identifier

10.1007/s10072-014-2002-3

Related Literature

Article Analysis
・Effects of rivastigmine transdermal patch
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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