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A randomized, double-blind, comparative study to assess the safety and efficacy of topical retapamulin ointment 1% versus oral linezolid in the treatment of secondarily infected traumatic lesions and impetigo due to methicillin-resistant Staphylococcus aureus.

Author: BretonJohn J, DalessandroMarybeth, LiGang, Scangarella-OmanNicole E, TanusTonny, TomaykoJohn F

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Topical retapamulin ointment 1% was less effective than oral linezolid in treating secondarily infected traumatic lesions (SITLs) or impetigo due to methicillin-resistant Staphylococcus aureus (MRSA). The clinical success rate at follow-up was significantly lower in the retapamulin group compared to the linezolid group.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To evaluate the clinical and bacteriological efficacy of topical retapamulin ointment 1% versus oral linezolid in the treatment of patients with secondarily infected traumatic lesions (SITLs; excluding abscesses) or impetigo due to methicillin-resistant Staphylococcus aureus (MRSA). DESI...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/25396674

データ提供：米国国立医学図書館（NLM）

Topical Retapamulin vs. Oral Linezolid: A Skin Infection Showdown

Infectious disease research continuously strives to develop effective treatments for skin infections, particularly those caused by drug-resistant bacteria. This randomized, double-blind, double-dummy, multicenter, comparative study examines the clinical and bacteriological efficacy of topical retapamulin ointment 1% versus oral linezolid in treating secondarily infected traumatic lesions (SITLs) and impetigo due to methicillin-resistant Staphylococcus aureus (MRSA). The authors enrolled 267 patients and found that oral linezolid had significantly higher clinical success rates at follow-up than topical retapamulin, particularly in patients with MRSA at baseline.

A Battle of the Sands: Topical vs. Oral Antibiotics

The study’s findings highlight the importance of careful consideration when choosing treatments for skin infections, particularly those caused by MRSA.

Navigating the Desert of Skin Infections

As a dermatologist, I often see patients with skin infections, and I’m always looking for the best treatment options. This study provides valuable insights into the relative efficacy of topical and oral antibiotics for treating SITLs and impetigo due to MRSA.

Dr. Camel's Conclusion

This randomized, double-blind, double-dummy, multicenter, comparative study examines the clinical and bacteriological efficacy of topical retapamulin ointment 1% versus oral linezolid in treating secondarily infected traumatic lesions (SITLs) and impetigo due to methicillin-resistant Staphylococcus aureus (MRSA). The authors enrolled 267 patients and found that oral linezolid had significantly higher clinical success rates at follow-up than topical retapamulin, particularly in patients with MRSA at baseline.

Date :
  1. Date Completed 2016-09-29
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

25396674

DOI: Digital Object Identifier

00129334-201412000-00006

Related Literature

Article Analysis
・Effects of retapamulin
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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