Effects of retapamulin: A Synthesis of Findings from 23 Studies

  1. Home
  2. Effects of retapamulin
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Effects of retapamulin: A Synthesis of Findings from 23 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Effects of retapamulin: A Synthesis of Findings from 23 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Major Research Findings

Retapamulin is a promising new treatment option for skin and soft tissue infections. 4 evaluated the effects of combining retapamulin with macrolide, lincosamide, and streptogramin (MLS) antibiotics against several bacteria, finding that retapamulin, combined with erythromycin or quinupristin, showed synergistic activity against Enterococcus faecalis, even strains highly resistant to erythromycin. Retapamulin's potential applications extend beyond skin infections. 9 identified retapamulin as a potential inhibitor of EphA4, a receptor tyrosine kinase linked to Alzheimer's disease, suggesting its potential use in treating this neurodegenerative disorder.

Multiple studies highlight retapamulin's effectiveness against skin infections, particularly those caused by Methicillin-resistant Staphylococcus aureus (MRSA). 20 , 23 , 21 , 2 , 3 These studies indicate retapamulin's broad antibacterial activity against a wide range of bacteria, including MRSA.

Retapamulin's effectiveness can be further enhanced when combined with other antibiotics. 11 demonstrated synergistic effects of retapamulin with tetracycline against Staphylococcus aureus. 13 found that retapamulin, combined with SPR741, was effective against Gram-negative bacteria like Escherichia coli, Klebsiella pneumoniae, and Acinetobacter baumannii. These findings suggest that retapamulin could be a valuable addition to combination therapies for various bacterial infections.

While topical application is common, 10 investigated the effectiveness of an oral retapamulin derivative, suggesting that oral administration could be a viable option in the future.

Benefits and Risks

Benefit Summary

Retapamulin is an effective antibacterial agent for treating skin infections, particularly those caused by MRSA. It has potential for combination therapy with other antibiotics and can be administered both topically and orally.

Risk Summary

Potential risks associated with retapamulin use include side effects like rashes, itching, and skin inflammation. Retapamulin should be avoided during pregnancy or breastfeeding.

Comparison Across Studies

Commonalities Across Studies

These studies consistently suggest that retapamulin is an effective antibacterial agent for treating skin infections. They also indicate the potential for retapamulin to be effective in combination therapy with other antibiotics.

Differences Across Studies

The studies vary in their focus on retapamulin's effectiveness, delivery methods, combination therapy partners, targeted bacteria, and research methodologies.

Consistency and Contradictions in Results

While there is consistency across multiple studies in demonstrating retapamulin's effectiveness, further research is needed to thoroughly understand the risks associated with its use and to assess the efficacy of combination therapies.

Considerations for Real-World Applications

While effective, retapamulin is not a universal treatment for skin infections. It's crucial to follow a doctor's guidance when considering retapamulin use. Additionally, retapamulin should be avoided during pregnancy and breastfeeding.

Current Limitations in Research

Research on retapamulin is still limited, particularly regarding long-term effects and the effectiveness of combination therapies. Further research is needed to address these areas.

Future Research Directions

Future research on retapamulin should focus on understanding its long-term effects, evaluating the effectiveness of combination therapies, and investigating the emergence of resistant bacteria.

Conclusion

Retapamulin shows promise as an effective treatment for skin infections, particularly those caused by MRSA. It's important to follow medical guidance when considering retapamulin and to be aware of its potential side effects. Continued research is necessary to better understand retapamulin's safety, efficacy, and long-term impact.

Literature analysis of 23 papers
Positive Content
23
Neutral Content
0
Negative Content
0
Article Type
2
0
0
5
23
1.

A comparison of the pharmacokinetic and pharmacodynamic properties of quinine and quinidine in healthy Thai males.

Author: KarbwangJ, DavisT M, LooareesuwanS, MoluntoP, BunnagD, WhiteN J

Treats malaria
Hypotension
Prolonged QTc interval

Quinine and quinidine, both antimalarial drugs, have different pharmacokinetic profiles. Quinidine has a shorter elimination half-time and is less bound to plasma proteins than quinine. Both drugs can prolong the QTc interval.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Retapamulin Activity Against Pediatric Strains of Mupirocin-resistant Methicillin-resistant Staphylococcus aureus.

Author: PatelAmi B, LighterJennifer, FulmerYi, CopinRichard, RatnerAdam J, ShopsinBo

Treatment for mupirocin-resistant infections

Retapamulin is a topical antibiotic that is used to treat skin infections. This study investigated the effectiveness of retapamulin against mupirocin-resistant Staphylococcus aureus, a type of bacteria that is resistant to the antibiotic mupirocin. Retapamulin was found to be effective against these resistant bacteria.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

3.

In vitro and in vivo antibacterial properties of peptide AMC-109 impregnated wound dressings and gels.

Author: HåkanssonJoakim, CavanaghJorunn Pauline, StensenWenche, MortensenBjarte, SvendsenJohn-Sigurd, SvensonJohan

Skin infection treatment

AMC-109, a synthetic cationic antimicrobial peptide mimic, demonstrated significantly higher antibacterial activity against Staphylococcus aureus and methicillin resistant S. aureus skin infections in vivo than current clinical standard therapy, Altargo cream and Fucidin cream, with up to a seven-log reduction in bacterial loads. This suggests AMC-109 is a promising new treatment for various skin infections.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Topical Ozenoxacin Cream 1% for Impetigo: A Review

Author: SchachnerLawrence, AndriessenAnneke, BhatiaNeal, GradaAyman, PateleDillon

Impetigo treatment
Antibiotic resistance

This review examined the challenges in treating impetigo (a bacterial skin infection) in children and adults. The review also discussed the use of ozenoxacin 1% cream, a new topical treatment for impetigo, and its safety and effectiveness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

6.

Retapamulin-Assisted Ribosome Profiling Reveals the Alternative Bacterial Proteome.

Author: MeydanSezen, MarksJames, KlepackiDorota, SharmaVirag, BaranovPavel V, FirthAndrew E, MargusTōnu, KefiAmira, Vázquez-LaslopNora, MankinAlexander S

This study describes a new technique for mapping alternative translation initiation sites in bacteria using an antibiotic, retapamulin. This technique revealed putative internal start sites in several genes, suggesting that alternative translation initiation is more common than previously thought.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

8.

Therapeutic efficacy of ozenoxacin in animal models of dermal infection with Staphylococcus aureus.

Author: TarragóCristina, EsquirolLluís Pérez, ArañóAntònia, LachampLaurence, D'AnielloFabiana, ZsoltIlonka

Effective impetigo treatment
Reduced bacterial load

Ozenoxacin ointment and cream at 1% concentration were found to be the most effective formulations in reducing bacterial load in Staphylococcus aureus-infected mice.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Identification of new EphA4 inhibitors by virtual screening of FDA-approved drugs.

Author: GuShuo, FuWing-Yu, FuAmy K Y, TongEstella Pui Sze, IpFanny C F, HuangXuhui, IpNancy Y

Alzheimer's disease treatment

Five FDA-approved drugs, ergoloid, cyproheptadine, nilotinib, abiraterone, and retapamulin, were identified as potential inhibitors of EphA4, a receptor tyrosine kinase involved in Alzheimer's disease (AD). Nilotinib, a kinase inhibitor, showed EphA4 inhibitory activity in cellular context, suggesting a potential fast-track approach for identifying and developing new treatments for AD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Antibacterial activity and pharmacokinetic profile of a promising antibacterial agent: 14-O-[(4-Amino-6-hydroxy-pyrimidine-2-yl)thioacetyl] mutilin.

Author: ShangRuofeng, YiYunpeng, ZhangChao, FuYunxing, LiangJianping, PuWanxia

Antibacterial efficacy

This study evaluated the cytotoxicity, antibacterial efficacy, and pharmacokinetic profile of a new pleuromutilin derivative, APTM.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Potentiation of Antibiotic Activity by a Novel Cationic Peptide: Potency and Spectrum of Activity of SPR741.

Author: CorbettDavid, WiseAndrew, LangleyTara, SkinnerKirsty, TrimbyEmily, BirchallStephen, DoraliAlain, SandifordStephanie, WilliamsJennifer, WarnPeter, VaaraMartti, ListerTroy

Treatment of Gram-negative bacterial infections

This study assessed the in vitro efficacy of combinations of SPR741 with conventional antibiotics against multidrug-resistant Gram-negative bacterial infections. The results suggest that SPR741 can potentiate the efficacy of several antibiotics against Escherichia coli, Klebsiella pneumoniae, and Acinetobacter baumannii.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

15.

Diagnosis and management of impetigo.

Author: VanRavensteinKathy, DurhamCatherine OʼConnor, WilliamsTiffany H, SmithWhitney

Impetigo management

Impetigo is a common bacterial skin infection, particularly in children. This article provides a practical guide for primary care providers on the diagnosis and management of impetigo, a condition that can affect individuals of all ages.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

17.

Decolonization in Prevention of Health Care-Associated Infections.

Author: SeptimusEdward J, SchweizerMarin L

Infection prevention
Allergic dermatitis
Resistance

Decolonization is an evidence-based intervention for preventing health care-associated infections (HAIs). Mupirocin is the gold standard agent for nasal decolonization. Chlorhexidine gluconate is recommended for topical decolonization.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

19.

Antibiotic resistance to Propionobacterium acnes: worldwide scenario, diagnosis and management.

Author: SardanaKabir, GuptaTanvi, GargVijay K, GhunawatSneha

Acne treatment
Antibiotic resistance

Antibiotic resistance in Propionobacterium is a growing concern. Resistance levels are high for macrolides, trimethoprim/sulfamethoxazole, and clindamycin, while tetracyclines and levofloxacin have lower resistance potential. Novel molecules with little resistance potential include octadecenedioic acid, phytosphingosine, lauric acid, retapamulin, resveratrol, T-3912, and NB-003.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

20.

A randomized, double-blind, comparative study to assess the safety and efficacy of topical retapamulin ointment 1% versus oral linezolid in the treatment of secondarily infected traumatic lesions and impetigo due to methicillin-resistant Staphylococcus aureus.

Author: TanusTonny, Scangarella-OmanNicole E, DalessandroMarybeth, LiGang, BretonJohn J, TomaykoJohn F

Treatment of MRSA infections
Lower clinical success rate

Topical retapamulin ointment 1% was less effective than oral linezolid in treating secondarily infected traumatic lesions (SITLs) or impetigo due to methicillin-resistant Staphylococcus aureus (MRSA). The clinical success rate at follow-up was significantly lower in the retapamulin group compared to the linezolid group.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

21.

Susceptibility of Staphylococcus aureus to topical agents in the United States: a sentinel study.

Author: BiedenbachDouglas J, BouchillonSamuel K, JohnsonSeth A, HobanDaryl J, HackelMeredith

Nasal decolonization
Skin infections treatment
Staphylococcus aureus resistance

Mupirocin and retapamulin are topical antibiotics used to treat skin infections. Rates of resistance to these drugs vary between countries and may be related to their usage and epidemiologic practices.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

22.

Pleuromutilins: use in food-producing animals in the European Union, development of resistance and impact on human and animal health.

Author: van DuijkerenEngeline, GrekoChristina, PringleMärit, BaptisteKeith Edward, CatryBoudewijn, JukesHelen, MorenoMiguel A, PombaM Constança Matias Ferreira, PyöräläSatu, RantalaMerja, RužauskasModestas, SandersPascal, TealeChristopher, ThrelfallE John, Torren-EdoJordi, TörnekeKarolina

Swine dysentery treatment
Antimicrobial resistance

Pleuromutilins are a class of antibiotics used primarily in veterinary medicine, especially for swine. There are concerns about increasing resistance to these drugs, which could have significant implications for animal health and even human health.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.