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Edoxaban effects on bleeding following punch biopsy and reversal by a 4-factor prothrombin complex concentrate.

Author: AntmanElliott M, BrownKaren S, DesaiMadhuri, DishyVictor, FengWenqin, FeussnerAnnette, GrossoMichael A, HeLing, LanzHans J, LomeliBarbara, MaaJen-Fue, VandellAlexander G, ZahirHamim

Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Edoxaban is a blood thinner (anticoagulant) used to prevent stroke and blood clots. This study investigated the ability of a 4-factor prothrombin complex concentrate (4F-PCC) to reverse the effects of edoxaban.
Paper Details　
Original Abstract of the Article :
The oral factor Xa inhibitor edoxaban has demonstrated safety and efficacy in stroke prevention in patients with atrial fibrillation and in the treatment and secondary prevention of venous thromboembolism. This study investigated the reversal of edoxaban's effects on bleeding measures and biomarkers...See full text at original site
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引用元：
https://doi.org/10.1161/CIRCULATIONAHA.114.013445

データ提供：米国国立医学図書館（NLM）

Reversing the Effects of Edoxaban on Bleeding Following Punch Biopsy

This study delves into the fascinating world of anticoagulation and its implications for medical procedures. It focuses on edoxaban, a potent oral factor Xa inhibitor, and investigates its effects on bleeding during punch biopsies. The research explores the potential for reversing edoxaban's effects using a 4-factor prothrombin complex concentrate (4F-PCC). This study aims to provide valuable insights into the management of bleeding complications in patients receiving edoxaban, ensuring optimal patient safety and procedural outcomes.

Reversing Edoxaban's Effects on Bleeding

The research findings suggest that 4F-PCC can effectively reverse the effects of edoxaban on bleeding measures and biomarkers. This discovery offers a promising avenue for managing bleeding complications in patients receiving edoxaban, particularly in situations where rapid reversal is necessary. These insights contribute to the evolving knowledge base on managing anticoagulation therapies and optimizing patient care.

Navigating Anticoagulation Therapies

This research highlights the importance of understanding the nuances of anticoagulation therapies and their potential impact on medical procedures. It underscores the need for careful patient monitoring and the availability of effective reversal agents to manage bleeding complications. This study serves as a valuable resource for clinicians, enabling them to navigate the complex world of anticoagulation with greater confidence and expertise.

Dr.Camel's Conclusion

Just like a skilled navigator guiding a caravan across the desert, this research illuminates the complexities of anticoagulation management. It emphasizes the importance of having the right tools and knowledge to handle potential challenges, ensuring that patients receive the optimal care and achieve positive outcomes. This study serves as a testament to the ongoing quest for safer and more effective treatments in the ever-evolving field of medicine.
Date :
  1. Date Completed 2015-03-26
  2. Date Revised 2022-03-09
Further Info :

Pubmed ID

25403645

DOI: Digital Object Identifier

10.1161/CIRCULATIONAHA.114.013445

Related Literature

Article Analysis
・Effects of edoxaban
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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