Imipramine and tetrabenazine: effects on monoamine receptor binding sites and phosphoinositide hydrolysis.

Author: BarkaiA I, ButlerP D, EdwardsE

Paper Details 
Original Abstract of the Article :
Treatment of rats for 21 days with tetrabenazine, a drug which depletes monoamines and is used behaviorally to screen for antidepressants, significantly decreased 5-HT2 receptor density, increased alpha 1-adrenoceptor density but did not alter beta-adrenoceptor density in homogenates of frontal cort...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1016/0014-2999(89)90657-2

データ提供:米国国立医学図書館(NLM)

Exploring the Effects of Imipramine and Tetrabenazine on Monoamine Receptors

This study investigates the effects of imipramine and tetrabenazine, two drugs used in the treatment of various neurological and psychiatric conditions, on monoamine receptor binding sites and phosphoinositide hydrolysis in rat brain tissue. The authors explored the interactions between these drugs, examining their impact on different receptor types and their potential mechanisms of action. Their findings provide valuable insights into the complex pharmacological interactions between these medications, offering a deeper understanding of their respective effects on the nervous system.

Unraveling the Complexities of Monoamine Receptor Interactions

The study reveals distinct effects of imipramine and tetrabenazine on different monoamine receptor types, suggesting a complex interplay between these drugs. While tetrabenazine depletes monoamines and is used as a behavioral screen for antidepressants, its effects on receptor density differ from those of imipramine. These findings highlight the need for a nuanced understanding of the pharmacological interactions between different medications, particularly when used in combination.

A Deeper Dive into the Neuropharmacology of Medications

This study emphasizes the importance of exploring the complex interactions between medications at the receptor level. The study's findings provide valuable insights into the neuropharmacology of imipramine and tetrabenazine, offering a deeper understanding of their mechanisms of action and potential interactions. This knowledge is crucial for optimizing drug treatment strategies and ensuring patient safety.

Dr.Camel's Conclusion

Just as the desert is filled with intricate pathways and hidden treasures, the human brain is a complex network of receptors and pathways. This research helps us navigate the intricate landscape of neuropharmacology, shedding light on the complex interactions between different medications. It’s a reminder that understanding the subtle nuances of these interactions is essential for effective and safe treatment strategies.
Date :
  1. Date Completed 1989-06-20
  2. Date Revised 2019-06-24
Further Info :

Pubmed ID

2540994

DOI: Digital Object Identifier

10.1016/0014-2999(89)90657-2

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.