Effects of tetrabenazine: A Synthesis of Findings from 23 Studies

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Original Abstract of the Article

Major Research Findings

Tetrabenazine is a medication that blocks the storage of neurotransmitters like dopamine inside brain cells. 9 , 5 , 2 , 23 , 14 , 16 , , 19 , 17 , 13 , 18 , 7 , , 15 , , , 21 , 6 , 1 , 4 , 3 , 20 , 12 , 10 , 22 , , 8 , 11 Research has shown that it can affect many aspects of the nervous system, including movement, mood, and motivation. For example, tetrabenazine can suppress the activity of dopamine neurons, which can alter movement control. It can also influence mood and motivation, particularly in areas of the brain that are involved in effort and drive, leading to decreased motivation and feelings of fatigue. Additionally, tetrabenazine can impact body temperature regulation and sleep patterns.

Benefits and Risks

Benefit Summary

Tetrabenazine is used to treat involuntary movements caused by neurological disorders like Huntington's disease. It is also sometimes used to treat movement disorders such as Tourette's syndrome and tardive dyskinesia, with the goal of improving movement symptoms associated with these conditions. Additionally, research suggests that tetrabenazine could be effective in treating methamphetamine addiction. 7

Risk Summary

Tetrabenazine can cause a variety of side effects. Common side effects include drowsiness, fatigue, depression, insomnia, anxiety, and movement disorders. Tetrabenazine may also cause digestive problems and cardiovascular issues. Furthermore, it may not be suitable for pregnant or breastfeeding women. It is crucial to follow a doctor's instructions when using tetrabenazine.

Comparison of Research

Research Similarities

These studies consistently demonstrate that tetrabenazine interferes with the storage of neurotransmitters like dopamine within brain cells, impacting various aspects of the nervous system. Many of the studies report that tetrabenazine affects movement, mood, and motivation. Additionally, it has been shown to influence body temperature regulation and sleep patterns.

Research Differences

These studies suggest that tetrabenazine might be effective in treating various neurological disorders, but there is variability in the specific diseases it is effective for and the extent of its effectiveness. Moreover, these studies highlight that tetrabenazine can cause a range of side effects. The frequency and severity of side effects can differ between studies.

Consistency and Contradictions in Results

While many studies agree that tetrabenazine suppresses the activity of dopamine neurons and affects movement control, there is less clarity on its impact on motivation and mood, and the underlying mechanisms are still being investigated. Some studies suggest that tetrabenazine can cause reduced motivation and fatigue, while others report no significant impact on mood or motivation. More research is needed to fully understand the effects of tetrabenazine on motivation and mood.

Considerations for Real-World Application

Tetrabenazine is used as a medication for neurological disorders, but due to the risk of side effects, it is crucial to use it under the guidance of a doctor. As tetrabenazine can influence motivation and mood, it is essential to consult with a doctor if it affects daily life negatively.

Limitations of Current Research

There is still much to learn about the effects of tetrabenazine. Further research is necessary to understand how tetrabenazine influences brain circuits and its specific impact on motivation and mood. More detailed research on the side effects of tetrabenazine is also needed.

Future Research Directions

To better understand the effects of tetrabenazine, research needs to explore how it affects brain circuitry, specifically how it influences motivation and mood. Additionally, research is required to find ways to minimize the side effects of tetrabenazine.

Conclusion

Tetrabenazine is a medication that disrupts the storage of neurotransmitters like dopamine inside brain cells, affecting various aspects of the nervous system. While used as a treatment for neurological disorders, it is important to use it under medical supervision due to the potential for side effects. There is still much to learn about the effects of tetrabenazine, and further research is needed for safer and more effective utilization. It is essential to consult a medical professional for guidance regarding the use of tetrabenazine.

Literature analysis of 23 papers
Positive Content
12
Neutral Content
5
Negative Content
6
Article Type
0
0
0
0
23
1.

Effects of the dopamine depleting agent tetrabenazine on detailed temporal parameters of effort-related choice responding.

Author: RenNaxin, Carratala-RosCarla, EcevitogluAlev, RotoloRenee A, EdelsteinGayle A, PresbyRose E, StevensonIan H, ChrobakJames J, SalamoneJohn D

Model motivation symptoms
Dopamine depletion

Tetrabenazine, a dopamine-depleting agent, alters effort-based choice in rats, shifting preference towards low-effort options. This effect seems to primarily affect the allocation of behavior towards food-seeking actions rather than consummatory behavior itself.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Partial reversal of the effort-related motivational effects of tetrabenazine with the MAO-B inhibitor deprenyl (selegiline): Implications for treating motivational dysfunctions.

Author: Contreras-MoraHector, RowlandMargaret A, YohnSamantha E, CorreaMerce, SalamoneJohn D

Depression treatment
Parkinsonism treatment

The study found that the MAO-B inhibitor deprenyl can help to reverse the low effort bias induced by tetrabenazine, which is a drug that causes depressive symptoms. This suggests that MAO-B inhibitors may be a potential treatment for the motivational symptoms of depression and Parkinsonism.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

5.

Oral Ingestion and Intraventricular Injection of Curcumin Attenuates the Effort-Related Effects of the VMAT-2 Inhibitor Tetrabenazine: Implications for Motivational Symptoms of Depression.

Author: YohnSamantha E, GorkaDea, MistryAnisha, CollinsSamantha, QianEmily, CorreaMerce, ManchandaArushi, BognerRobin H, SalamoneJohn D

Anergia/fatigue treatment

Curcumin is a natural compound found in turmeric. This study looked at whether curcumin could help to reverse the low-effort bias induced by tetrabenazine, a drug that is used to treat movement disorders. The study found that curcumin reversed the low-effort bias in rats.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Effort-related motivational effects of the VMAT-2 inhibitor tetrabenazine: implications for animal models of the motivational symptoms of depression.

Author: NunesEric J, RandallPatrick A, HartEvan E, FreelandCharlotte, YohnSamantha E, BaqiYounis, MüllerChrista E, López-CruzLaura, CorreaMercè, SalamoneJohn D

Animal model for depression
Reverses effort-related choice deficits

This study investigated the effects of tetrabenazine, a VMAT inhibitor, on effort-related choice behavior in rats. Tetrabenazine produced a dose-related decrease in lever pressing and an increase in chow intake, suggesting a shift in response choice. The effects of tetrabenazine were reversed by MSX-3 and bupropion.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Tetrabenazine inhibition of monoamine uptake and methamphetamine behavioral effects: locomotor activity, drug discrimination and self-administration.

Author: MeyerA C, HortonD B, NeugebauerN M, WootersT E, NickellJ R, DwoskinL P, BardoM T

Treat methamphetamine abuse
Increase methamphetamine self-administration

This study investigated the potential of tetrabenazine (TBZ) as a treatment for methamphetamine abuse. TBZ inhibited dopamine transporter (DAT), serotonin transporter (SERT), and vesicular monoamine transporter-2 (VMAT2). However, TBZ lacked behavioral specificity as an inhibitor of methamphetamine-induced reinforcement.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

8.

Short-term effects of tetrabenazine on chorea associated with Huntington's disease.

Author: KenneyChristopher, HunterChristine, DavidsonAnthony, JankovicJoseph

Chorea improvement

This observational study assessed the short-term effects of tetrabenazine (TBZ) on choreic movements in Huntington's disease patients. TBZ reduced chorea scores by an average of 42.4% for approximately 5 hours following a single dose.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Apparent opposite effects of tetrabenazine and reserpine on the toxic effects of 1-methyl-4-phenylpyridinium or 6-hydroxydopamine on nigro-striatal dopaminergic neurons.

Author: ClerenCarine, NaudinBertrand, CostentinJean

Neuroprotection

VMAT2, a protein responsible for storing neurotransmitters, protects against neurotoxin-induced damage. This study investigates the role of VMAT2 in 6-OHDA neurotoxicity. While initially seeming protective, VMAT2 inhibition actually potentiated neurotoxicity, likely due to hypothermia.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

10.

Long-term effects of tetrabenazine in hyperkinetic movement disorders.

Author: JankovicJ, BeachJ

Movement disorder treatment
Side effects

This study found that tetrabenazine (TBZ) was effective and safe for treating a variety of hyperkinetic movement disorders, with marked improvement in over 80% of patients. The most common side effects, including drowsiness and parkinsonism, were manageable with dose reduction.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Imipramine and tetrabenazine: effects on monoamine receptor binding sites and phosphoinositide hydrolysis.

Author: ButlerP D, EdwardsE, BarkaiA I

Antagonistic interactions
Tetrabenazine effect

Tetrabenazine, a drug that depletes monoamines, decreased 5-HT2 receptor density and increased alpha 1-adrenoceptor density in rat frontal cortices, indicating that its effects on receptor density differ from those of reserpine.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

13.

Effects of reserpine and tetrabenazine on catecholamine and ATP storage in cultured bovine adrenal medullary chromaffin cells.

Author: CaugheyB, KirshnerN

Store catecholamines

Reserpine and tetrabenazine, drugs that deplete catecholamines, reduced ATP levels in chromaffin vesicles of adrenal medulla cells. This suggests that interactions between ATP and catecholamines are important for storing these compounds within vesicles.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

14.

Lithium attenuates dopamine depleting effects of reserpine and tetrabenazine but not that of alpha methyl-p-tyrosine.

Author: RechesA, HassanM N, JacksonV R, FahnS

Attenuated effects

Lithium attenuated the dopamine-depleting effects of reserpine and tetrabenazine in rat brains. This interaction may affect the efficacy of these drugs in patients with tardive dyskinesia or dystonia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

Comparative effects of delta 9-tetrahydrocannabinol, tetrabenazine and chlorpromazine on rectal temperature in the rat.

Author: DiamantisW, MeltonJ, SofiaR D

Hyperthermia
Hypothermia

Tetrabenazine produced a biphasic response in rectal temperature of rats, with an initial hyperthermia followed by hypothermia. This effect was similar to that of THC, supporting the idea that the two drugs act via similar mechanisms. Chlorpromazine, in contrast, only caused hypothermia.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

23.

Effects of rubidium on behavioral responses to methamphetamine and tetrabenazine.

Author: FurukawaT, TokudaM

Catalepsy
Jumping
Straub tail

Rubidium was found to potentiate the excitatory action of methamphetamine on spontaneous locomotor activities in mice.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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