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The effect of triple vs. double nonopioid therapy on postoperative pain and functional outcome after abdominal hysterectomy: a randomised double-blind control trial.

Author: DugganScott, Dumerton-ShoreDeborah, GilronIan, McGrathMichael, OrrElizabeth, RooneyRachel, TuDongsheng

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the effectiveness of adding a third non-opioid analgesic to double-drug regimens for pain management after abdominal hysterectomy. The study failed to demonstrate a significant benefit of the triple regimen compared to double-drug regimens.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Movement-evoked pain is more severe than pain at rest and is likely to interfere more with functional recovery after surgery. OBJECTIVE: To compare triple vs. double nonopioid perioperative analgesic regimens in women undergoing abdominal hysterectomy. DESIGN: A randomised, parallel de...See full text at original site
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引用元：
https://doi.org/10.1097/EJA.0000000000000190

データ提供：米国国立医学図書館（NLM）

Triple vs. Double Nonopioid Therapy: A Journey Through the Sands of Postoperative Pain

Postoperative pain is a common and often challenging experience for patients undergoing surgery. This study investigated the effectiveness of different nonopioid analgesic regimens in reducing postoperative pain and improving functional recovery after abdominal hysterectomy.

The study compared a triple nonopioid regimen (acetaminophen, meloxicam, and gabapentin) to three different double-drug regimens. The study found that the triple regimen did not demonstrate significant benefits over the double-drug regimens. However, all four analgesic regimens were well-tolerated, and exploratory analyses revealed consistent negative correlations between pain and functional outcomes, such as the timed up and go test (TUG).

The Quest for Optimal Pain Management

This research highlights the importance of multimodal analgesic approaches in managing postoperative pain. While the triple regimen did not show significant advantages over double-drug regimens, the study suggests that exploring different combinations of nonopioid analgesics may lead to improved pain management and functional recovery.

A Camel's Perspective: The Oasis of Pain Relief

Postoperative pain can feel like a harsh desert wind, making recovery challenging. This study explores the effectiveness of different pain management strategies, providing insights into the search for the perfect oasis of pain relief.

Dr. Camel's Conclusion

This trial failed to demonstrate substantial benefits with the addition of a third nonopioid analgesic to three different double-drug regimens. Further research is needed to more definitively support expanding multimodal analgesic practices. Our results demonstrate consistent correlations between evoked pain and functional outcomes further emphasizing the need for improved analgesic regimens that will accelerate postsurgical functional recovery.
Date :
  1. Date Completed 2016-05-15
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

25485880

DOI: Digital Object Identifier

10.1097/EJA.0000000000000190

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SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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