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Population pharmacokinetics of morphine and morphine-6-glucuronide following rectal administration--a dose escalation study.

Author: BrokjærAnne, ChristrupLona Louring, DahanAlbert, DrewesAsbjørn Mohr, KreilgaardMads, OlesenAnne Estrup, SimonssonUlrika S H

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study aimed to develop a population pharmacokinetic model of liquid rectal morphine and morphine-6-glucoronide (M6G), simulate clinically relevant rectal doses of morphine, and assess the tolerability and safety.
Paper Details　
Original Abstract of the Article :
To safely and effectively administer morphine as liquid formulation via the rectal route, a thorough understanding of the pharmacokinetics is warranted. The aims were: (1) to develop a population pharmacokinetic model of liquid rectal morphine and morphine-6-glucoronide (M6G), (2) to simulate clinic...See full text at original site
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引用元：
https://doi.org/10.1016/j.ejps.2014.12.004

データ提供：米国国立医学図書館（NLM）

Mapping the Desert of Morphine Pharmacokinetics: A Dose Escalation Study

The field of [pain management] is constantly seeking safer and more effective ways to deliver pain relief. This study investigates the pharmacokinetics of [morphine] following [rectal administration]. The authors developed a [population pharmacokinetic model] for both [morphine] and its metabolite, [morphine-6-glucuronide (M6G)]. This model provides a valuable tool for understanding the absorption, distribution, metabolism, and excretion of [morphine] following [rectal administration], paving the way for more precise and personalized dosing strategies.

A Dose of Understanding: Unveiling the Pharmacokinetics of Rectal Morphine

This study sheds light on the intricate pharmacokinetics of [morphine] when administered rectally. The development of a [population pharmacokinetic model] allows for a more accurate understanding of how [morphine] is absorbed, distributed, and eliminated in the body. This knowledge is essential for optimizing [morphine] dosing and ensuring safe and effective pain relief.

Navigating the Desert of Pain Management: Personalized Approaches to Dosing

The desert of chronic pain can be a challenging landscape to navigate. This study emphasizes the importance of personalized approaches to pain management, particularly in the realm of [morphine] administration. By understanding the pharmacokinetics of [morphine], healthcare professionals can tailor dosing strategies to individual patients, ensuring optimal pain relief while minimizing potential adverse effects.

Dr. Camel's Conclusion

Just as a camel traverses the vast desert landscape, seeking the most efficient path to reach its destination, healthcare professionals strive to find the most effective and safe ways to manage pain. This study provides valuable insights into the pharmacokinetics of [morphine] following [rectal administration], offering a roadmap for personalized dosing strategies. By understanding the nuances of [morphine] absorption, distribution, and elimination, we can better navigate the desert of chronic pain and provide patients with the optimal pain relief they deserve.

Date :
  1. Date Completed 2015-09-17
  2. Date Revised 2022-03-11
Further Info :

Pubmed ID

25486331

DOI: Digital Object Identifier

10.1016/j.ejps.2014.12.004

Related Literature

Article Analysis
・Effects of morphine rectal
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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