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MIL-53(Fe), MIL-101, and SBA-15 porous materials: potential platforms for drug delivery.
Author: GordonJeff, KazemianHossein, RohaniSohrab
Original Abstract of the Article :
Conventional drug administration suffers from several drawbacks, including a lack of specificity for diseased tissue, the necessity of large and frequent doses, and adverse side effects. Great effort is currently being devoted to developing nanoparticle-based therapeutics capable of prolonging drug ...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元：
https://doi.org/10.1016/j.msec.2014.11.046
データ提供：米国国立医学図書館（NLM）
Unlocking the Potential of Porous Materials for Drug Delivery
The world of drug delivery is constantly evolving, seeking to overcome limitations of conventional methods, such as lack of target specificity, frequent dosing requirements, and adverse side effects. This study investigates the potential of porous materials like MIL-53(Fe), MIL-101, and SBA-15 as matrices for controlled drug delivery. The authors explore their ability to adsorb and release drugs in a controlled manner, demonstrating their potential to address existing challenges in drug delivery. The study focused on the adsorption and in vitro release of acetaminophen, progesterone, and stavudine using MIL-53(Fe), MIL-101, and SBA-15 as drug carriers. The nanomaterials were loaded with 20 wt.% of each drug using incipient wetness impregnation. Characterization techniques, including BET, DSC, and XRPD, confirmed the successful incorporation of the drugs within the porous structures. The study observed that the loaded drugs were released in a diffusion-controlled process, with release times varying depending on the porous material and drug. For example, acetaminophen was released over six days from MIL-53(Fe), highlighting the material's ability to adapt its porosity and optimize drug-matrix interactions. MIL-101, with its larger pore diameters and weaker host-guest interactions, exhibited shorter release times, as demonstrated by the complete release of stavudine within five days. SBA-15, characterized by its rapid drug dissolution and diffusion out of the mesopores, showed the fastest release of all the tested drugs.
Novel Drug Delivery Strategies for Improved Therapeutic Outcomes
The study demonstrates the potential of porous materials like MIL-53(Fe), MIL-101, and SBA-15 for controlled drug delivery. The varying release profiles observed in the study suggest that these materials could be tailored for specific therapeutic applications.
The Future of Drug Delivery: A Journey Through Porous Materials
The use of porous materials for drug delivery is a promising frontier in pharmaceutical research. These materials offer the potential to enhance drug efficacy and safety, ultimately improving patient outcomes. Further research is needed to optimize their use for various drug delivery applications.
Dr.Camel's Conclusion
Think of porous materials as a camel's hump, storing essential resources for a long journey through the desert. Just as a camel's hump can sustain the animal for days, these porous materials can hold and release drugs in a controlled manner, providing sustained therapeutic benefits. This study sheds light on the potential of porous materials to revolutionize drug delivery, offering a brighter future for patients battling various ailments.
Date :
- Date Completed 2015-08-07
- Date Revised 2019-12-10
Further Info :
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