Enhanced anticancer properties of lomustine in conjunction with docosahexaenoic acid in glioblastoma cell lines.

Author: Cohen-GadolAaron A, HarveyKevin A, PollokKaren, SaaddatzadehM Reza, SiddiquiRafat A, WangHaiyan, XuZhidong

Paper Details 
Original Abstract of the Article :
Glioblastoma is a rapidly infiltrating tumor that consistently rematerializes despite various forms of aggressive treatment. Brain tumors are commonly treated with alkylating drugs, such as lomustine, which are chemotherapeutic agents. Use of these drugs, however, is associated with serious side eff...See full text at original site
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引用元:
https://doi.org/10.3171/2014.10.JNS14759

データ提供:米国国立医学図書館(NLM)

Fighting Brain Tumors with a Double Whammy: Lomustine and DHA Unite

Glioblastoma, an aggressive brain tumor, poses a formidable challenge to medical science, with its tendency to rematerialize despite aggressive treatments. Chemotherapeutic agents, like lomustine, are commonly used to combat these tumors, but their use is often accompanied by serious side effects. This study explores a promising strategy to mitigate these side effects by combining lomustine with docosahexaenoic acid (DHA), an omega-3 fatty acid abundant in the brain and known for its anticancer potential.

The Synergistic Power of Lomustine and DHA Against Glioblastoma

This study investigates the combined effect of lomustine and DHA on glioblastoma cell lines. The researchers discovered that the combination of these agents resulted in enhanced anticancer properties compared to lomustine alone. This synergy could lead to more effective treatment strategies for glioblastoma, potentially reducing the need for high doses of chemotherapy and associated side effects. This finding suggests that DHA might play a crucial role in enhancing the effectiveness of lomustine while minimizing its adverse effects.

A Glimpse of Hope for Glioblastoma Patients

The potential of DHA to enhance the efficacy of lomustine and minimize side effects offers a glimmer of hope for patients battling glioblastoma. This research paves the way for exploring new and less toxic treatment strategies for this devastating disease. By harnessing the power of naturally occurring substances like DHA, we can potentially find new ways to combat this challenging brain tumor.

Dr.Camel's Conclusion

This study provides compelling evidence that DHA could be a valuable adjunct to lomustine in the treatment of glioblastoma. This research offers a promising path towards more effective and less toxic treatment options for patients battling this challenging disease. The combined power of lomustine and DHA could lead to a brighter future for those affected by glioblastoma.
Date :
  1. Date Completed 2015-04-20
  2. Date Revised 2015-03-02
Further Info :

Pubmed ID

25526274

DOI: Digital Object Identifier

10.3171/2014.10.JNS14759

Related Literature

SNS
PICO Info
in preparation
Languages

English

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