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Treatments of Negative Symptoms in Schizophrenia: Meta-Analysis of 168 Randomized Placebo-Controlled Trials.

Author: CarpenterWilliam, Fusar-PoliPaolo, McGuirePhilip, PapanastasiouEvangelos, RocchettiMatteo, ShergillSukhwinder, StahlDaniel

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

While most treatments for schizophrenia reduced negative symptoms compared to placebo, none reached the threshold for clinically significant improvement.
Paper Details　
Original Abstract of the Article :
OBJECTIVES: Existing treatments for schizophrenia can improve positive symptoms, but it is unclear if they have any impact on negative symptoms. This meta-analysis was conducted to assess the efficacy of available treatments for negative symptoms in schizophrenia. METHODS: All randomized-controlled...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466178/

データ提供：米国国立医学図書館（NLM）

Treatments of Negative Symptoms in Schizophrenia

Schizophrenia, a complex mental illness, is like a desert mirage that distorts reality, making it difficult to navigate everyday life. This meta-analysis examines the effectiveness of various treatments for negative symptoms in schizophrenia, a crucial aspect of this disorder that often goes overlooked.

Limited Efficacy for Negative Symptoms in Schizophrenia

The meta-analysis revealed that while most treatments showed some statistical significance in reducing negative symptoms, none reached the threshold for clinically meaningful improvement. It's like finding a small puddle of water in the desert, providing some relief but not a lasting solution.

Continuing the Search for Effective Treatments

This research highlights the need for further research and development of more effective treatments for negative symptoms in schizophrenia. It's like continuing to explore the desert for a true oasis, searching for a more lasting and transformative solution.

Dr.Camel's Conclusion

This meta-analysis underscores the ongoing challenges in treating negative symptoms in schizophrenia. It's a reminder that the desert of mental health research is vast and complex, requiring persistence and innovation to find effective solutions for those affected by this challenging condition.

Date :
  1. Date Completed 2016-03-29
  2. Date Revised 2023-12-12
Further Info :

Pubmed ID

25528757

DOI: Digital Object Identifier

PMC4466178

Related Literature

Article Analysis
・Effective treatment of schizophrenia
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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