Paper Details 
Original Abstract of the Article :
The drug 5-fluoro-2-deoxyuridine-C8 (FUdR-C8), one of the lipophilic prodrugs of FUdR, was dissolved in an oily lymphographic agent (Lipiodol Ultra Fluid, Andre Gelbe Laboratory, Paris, France; Ethiodol, Savage Laboratories, Melville, NY) and used for the intraarterial treatment of malignant liver t...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1002/1097-0142(19891215)64:12<2437::aid-cncr2820641207>3.0.co;2-h

データ提供:米国国立医学図書館(NLM)

Targeting Liver Tumors with Precision: Intraarterial Infusion of FUdR-C8

The fight against cancer is a journey of continuous innovation, with researchers constantly exploring new approaches to target and destroy malignant cells. This study examines the potential of intraarterial infusion of 5-fluoro-2-deoxyuridine-C8 (FUdR-C8), a lipophilic prodrug, for the treatment of malignant liver tumors. The researchers dissolved FUdR-C8 in a lymphographic agent and delivered it directly to the tumor site. The study reports encouraging results, showing a significant response rate in both hepatocellular carcinoma and metastatic liver tumors, along with improved survival rates. This research provides compelling evidence for the potential of targeted drug delivery in the fight against liver cancer.

A Precise Strike: Intraarterial Infusion for Liver Cancer Treatment

The study's findings demonstrate the effectiveness of intraarterial infusion of FUdR-C8 in achieving a significant response rate in liver cancer. The researchers observed a 27.6% response rate for hepatocellular carcinomas and 46.1% for metastatic liver tumors, along with improved survival rates. These results suggest that this targeted approach could be a valuable weapon in the arsenal against liver cancer. It is worth noting that the study also found a significant decrease in tumor marker levels in a majority of patients, suggesting that this treatment modality may be a valuable tool for monitoring tumor progression and evaluating treatment efficacy.

Navigating the Treatment Landscape: A Precision-Based Approach to Liver Cancer

The study's findings highlight the importance of personalized treatment approaches tailored to individual patient needs. Just as a skilled navigator chooses the optimal route through a vast desert, clinicians must carefully consider the individual characteristics of each patient when selecting the most appropriate treatment strategy. The research suggests that intraarterial infusion of FUdR-C8 could be a valuable addition to the treatment landscape for liver cancer, offering a more targeted and potentially more effective approach to combating this disease.

Dr. Camel's Conclusion

This research presents a compelling case for the potential of intraarterial infusion of FUdR-C8 in the treatment of liver cancer. By delivering the drug directly to the tumor site, this approach offers a targeted and potentially more effective means of combating this disease. The study's encouraging results provide a beacon of hope for patients seeking innovative treatments for liver cancer.

Date :
  1. Date Completed 1990-01-03
  2. Date Revised 2019-06-19
Further Info :

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.