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The effects of gastric pH and food on the pharmacokinetics of a new oral cephalosporin, cefpodoxime proxetil.

Author: BarkerK B, BattsD H, EulerA R, HealdD L, HughesG S, PatelR K, SpillersC R, WattsK C

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study in healthy subjects investigated the effects of gastric pH and food on the pharmacokinetics of cefpodoxime proxetil, an antibiotic. Absorption was best at low gastric pH or in the presence of food, suggesting a complex interplay between gastrointestinal function and the drug's pharmacokinetic profile.
Paper Details　
Original Abstract of the Article :
The effects of alteration of gastric pH and food on the pharmacokinetics of 200 mg doses of cefpodoxime proxetil tablets were studied in two separate randomized, open label, crossover studies in healthy subjects. In the pH study (n = 17 subjects), there was a lead-in period done under fasting condit...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
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引用元：
https://doi.org/10.1038/clpt.1989.204

データ提供：米国国立医学図書館（NLM）

Investigating the Pharmacokinetics of Cefpodoxime Proxetil

The realm of pharmaceutical research is constantly evolving, seeking to optimize drug delivery and enhance therapeutic outcomes. This study explores the pharmacokinetics of cefpodoxime proxetil, a new oral cephalosporin, in relation to gastric pH and food consumption. The researchers conducted two separate studies, examining the impact of gastric pH alterations and various dietary compositions on the absorption and bioavailability of this antibiotic. The findings shed light on the complex interplay between gastric environment, food intake, and drug absorption.

Gastric pH and Food Intake: Influencing Cefpodoxime Proxetil Absorption

The study reveals that the absorption of cefpodoxime proxetil is significantly influenced by both gastric pH and the presence of food. Lower gastric pH, often found in fasting conditions, was associated with higher peak plasma concentrations and overall bioavailability of the antibiotic. Interestingly, the presence of food, particularly high protein diets, also enhanced absorption. These findings highlight the importance of considering these factors in optimizing drug administration for maximum efficacy.

Optimizing Drug Absorption: Tailoring Treatment Strategies

This study underscores the need for tailored treatment strategies in antibiotic therapy, considering individual patient factors like gastric pH and dietary habits. The findings provide valuable insights into the complex interplay between drug absorption and the gastrointestinal environment, emphasizing the importance of optimizing drug administration for optimal therapeutic outcomes.

Dr.Camel's Conclusion

Imagine a desert oasis, where the water represents cefpodoxime proxetil, a vital resource for combatting infections. This study reveals that the absorption of this antibiotic is influenced by the surrounding environment, whether it's the acidity of the stomach or the presence of food. Understanding these factors, like navigating a treacherous desert landscape, is crucial for ensuring the efficient delivery and effectiveness of this life-saving drug.
Date :
  1. Date Completed 1990-01-26
  2. Date Revised 2023-12-13
Further Info :

Pubmed ID

2557183

DOI: Digital Object Identifier

10.1038/clpt.1989.204

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in preparation
Languages

English

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