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The next-generation ALK inhibitors.

Author: PallGeorg

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review discusses the mechanisms of crizotinib resistance in ALK-rearranged lung adenocarcinomas and the development of second-generation ALK inhibitors. Crizotinib is a standard first-line treatment for this type of cancer, but resistance often develops. The review provides an overview of the preclinical background and clinical development of these second-generation inhibitors, which are aimed at overcoming crizotinib resistance.
Paper Details　
Original Abstract of the Article :
Crizotinib now is accepted as the standard first-line treatment of ALK-rearranged lung adenocarcinomas. To overcome the problem of crizotinib resistance, second-generation ALK inhibitors are in development. The aim of this review is to give an overview on the mechanisms behind crizotinib resistance ...See full text at original site
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引用元：
https://doi.org/10.1097/CCO.0000000000000165

データ提供：米国国立医学図書館（NLM）

Next-Generation ALK Inhibitors: A New Era in Lung Cancer Treatment

This research explores the exciting landscape of lung cancer treatment, focusing on the development of next-generation ALK inhibitors to overcome resistance to current therapies. It's like embarking on a journey through a desert, seeking new and innovative solutions to combat this formidable disease.

Overcoming Resistance: A Quest for New Weapons Against Lung Cancer

This study investigates the mechanisms behind crizotinib resistance and the development of second-generation ALK inhibitors. It's like uncovering the secrets of a desert fortress, seeking new strategies to penetrate its defenses. The research highlights the importance of understanding resistance mechanisms and developing new therapies to address this challenge, offering a potential path toward more effective and lasting treatments for lung cancer.

A New Dawn for Lung Cancer Treatment

The fight against lung cancer is a continuous battle. This research highlights the promising potential of next-generation ALK inhibitors to overcome resistance and improve outcomes for patients. It's like discovering a new source of water in the desert, bringing renewed hope and energy to the fight against this deadly disease.

Dr. Camel's Conclusion

This study offers a glimpse into the exciting future of lung cancer treatment, revealing the potential of next-generation ALK inhibitors to overcome resistance and provide a more effective path to recovery. It's a reminder that the desert of lung cancer research is vast, but with relentless exploration and innovation, we can uncover new oases of hope and solutions for patients facing this challenge.

Date :
  1. Date Completed 2015-09-30
  2. Date Revised 2022-03-11
Further Info :

Pubmed ID

25588040

DOI: Digital Object Identifier

10.1097/CCO.0000000000000165

SNS
PICO Info
in preparation
Languages

English

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