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Different effects of cholestyramine on postprandial secretions of cholecystokinin and peptide YY in women with bulimia nervosa.

Author: BiniSilvia, CellaSilvano G, MarazziNicoletta, MastromoDaniele, MonteleoneAlessio M, MonteleonePalmiero, RigamontiAntonello E, SartorioAlessandro, ScognamiglioPasquale

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Cholestyramine, an anion exchanger that reduces lipid digestion, was studied in bulimic and healthy women to see its effects on the release of cholecystokinin (CCK) and peptide YY (PYY) after a high-fat meal. The study aimed to understand the physiology of these peptides in bulimia nervosa, as patients with this disorder exhibit reduced postprandial levels of CCK and PYY.
Paper Details　
Original Abstract of the Article :
Patients with bulimia nervosa (BN) are reported to have decreased postprandial levels of cholecystokinin (CCK) and peptide YY (PYY). Fatty nutrients are the most powerful stimulus for releasing these peptides. Cholestyramine is an anion exchanger which adsorbs bile salts and reduces the digestion of...See full text at original site
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引用元：
https://doi.org/10.1159/000368160

データ提供：米国国立医学図書館（NLM）

Cholestyramine: Navigating the Desert of Bulimia Nervosa

The desert of eating disorders is a challenging landscape, with bulimia nervosa (BN) posing a significant threat to individuals' well-being. This study explores the effects of cholestyramine on postprandial secretions of cholecystokinin (CCK) and peptide YY (PYY) in women with BN. It's like exploring a desert landscape, seeking to understand the intricate mechanisms that contribute to this disorder.

Cholestyramine: A Potential Influence on Gut Hormones

The researchers meticulously investigated the impact of cholestyramine on the release of key gut hormones, CCK and PYY, in women with BN. It's like carefully mapping out the desert landscape, understanding the complex interplay between hormones and eating behavior. The study reveals that cholestyramine, an agent that binds bile acids, may have a different effect on CCK and PYY secretion in women with BN compared to healthy women.

The Need for Further Investigation

The study emphasizes the need for further research to fully understand the role of cholestyramine and gut hormones in the pathophysiology of BN. It's like venturing deeper into the desert, seeking to uncover more about the complex interplay of factors contributing to this disorder.

Dr. Camel's Conclusion

This study offers valuable insights into the potential role of gut hormones in BN. It's a reminder that the desert of eating disorders requires a multifaceted approach, involving a deep understanding of the underlying biological mechanisms and the development of targeted therapies.

Date :
  1. Date Completed 2016-02-29
  2. Date Revised 2015-03-13
Further Info :

Pubmed ID

25592490

DOI: Digital Object Identifier

10.1159/000368160

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Languages

English

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