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Empirical therapy of the male with clomiphene in couples with unexplained infertility.

Author: AdelsonH G, ChaseJ S, CheckJ H, NowrooziK, WuC H

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

A study of 100 couples with unexplained infertility found that clomiphene citrate treatment of the male partner significantly improved pregnancy rates (58%) compared to placebo (16%). The mechanism of action is unclear, but potential explanations include improved sperm quality or seminal plasma changes.
Paper Details　
Original Abstract of the Article :
Unexplained infertility may be secondary to a cryptic male or female factor. Although most often empirical therapy of the female partner may be attempted, clomiphene has been claimed, after uncontrolled studies, to improve fertility in men with subnormal spermograms. We chose to determine if clomiph...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/2565314

データ提供：米国国立医学図書館（NLM）

Clomiphene: A Potential Solution for Unexplained Infertility

Infertility, a challenging and emotionally taxing journey for couples, is a complex area of study. This study investigates the potential of clomiphene citrate, a medication commonly used to treat female infertility, as a treatment option for unexplained infertility in men. The researchers conducted a randomized, double-blind study involving 100 couples, comparing the effects of clomiphene citrate to ascorbic acid. Their findings suggest that clomiphene citrate may significantly improve fertility rates in couples with unexplained infertility, despite normal-appearing semen parameters.

Clomiphene: A Promising Treatment for Unexplained Infertility

This study provides intriguing evidence for the potential benefits of clomiphene citrate in treating unexplained infertility in couples. The study's findings, based on a randomized, double-blind trial, indicate that clomiphene citrate may significantly improve fertility rates in couples with unexplained infertility. While further research is needed to fully understand the mechanisms involved and to establish optimal dosing and treatment protocols, clomiphene citrate shows promise as a potential treatment option for this challenging condition.

Clomiphene: A Potential Key to Unlocking Fertility

This study highlights the potential of clomiphene citrate to unlock fertility in couples with unexplained infertility. The researchers found that clomiphene citrate may significantly improve fertility rates, suggesting that it could be a valuable tool in managing this challenging condition. While further investigation is necessary to confirm these findings and to understand the long-term effects of clomiphene citrate treatment, this study provides a valuable starting point for exploring the potential of this medication in improving fertility outcomes.

Dr.Camel's Conclusion

This study provides intriguing evidence for the potential benefits of clomiphene citrate in treating unexplained infertility in couples. While further research is needed, the study's findings suggest that clomiphene citrate could offer a new avenue for treatment and a potential oasis of hope for couples struggling with infertility. This research highlights the importance of exploring innovative approaches to treating infertility, considering both male and female factors that may contribute to this complex condition.
Date :
  1. Date Completed 1989-05-31
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

2565314

DOI: Digital Object Identifier

2565314

SNS
PICO Info
in preparation
Languages

English

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