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Ferrous sulfate supplementation causes significant gastrointestinal side-effects in adults: a systematic review and meta-analysis.

Author: ManderAdrian P, PereiraDora I A, PowellJonathan J, StecherLynne, TolkienZoe

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Ferrous sulfate is associated with a significant increase in gastrointestinal-specific side-effects but does not find a relationship with dose.
Paper Details　
Original Abstract of the Article :
BACKGROUND: The tolerability of oral iron supplementation for the treatment of iron deficiency anemia is disputed. OBJECTIVE: Our aim was to quantify the odds of GI side-effects in adults related to current gold standard oral iron therapy, namely ferrous sulfate. METHODS: Systematic review and met...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336293/

データ提供：米国国立医学図書館（NLM）

Iron Supplements and Your Gut: A Tale of Two Metals

The field of [iron deficiency anemia] is always striving to find the best solutions for patients. This study delves into the world of [oral iron supplements], specifically [ferrous sulfate], and its impact on our digestive system. Using a [systematic review and meta-analysis] approach, the researchers analyzed data from multiple studies to get a clearer picture of the situation. Their findings suggest that [ferrous sulfate] can increase the risk of [gastrointestinal side-effects] compared to either [placebo] or [intravenous iron]. This discovery is particularly important for understanding how different forms of iron supplementation affect patients.

Understanding the Odds: A Look at the Numbers

The research revealed that [ferrous sulfate] was associated with a significantly higher chance of [gastrointestinal issues] when compared to [placebo] (odds ratio of 2.32). Even when compared to [intravenous iron], [ferrous sulfate] still presented a higher risk (odds ratio of 3.05). This suggests that the route of administration of iron can significantly affect the likelihood of experiencing [gastrointestinal side-effects].

A Balancing Act: Iron and Your Digestive System

This study emphasizes the importance of considering the potential [side effects] of iron supplementation. While [ferrous sulfate] is an effective treatment for [iron deficiency anemia], it's crucial to be aware of its potential impact on your digestive system. It's like navigating a desert: you need to replenish your resources, but choosing the wrong source can lead to discomfort. Understanding the risks and benefits of different iron therapies is crucial for maintaining a healthy balance.

Dr. Camel's Conclusion

While [ferrous sulfate] is a commonly used treatment for [iron deficiency anemia], it can lead to some unpleasant digestive experiences. The findings of this study highlight the need for a more nuanced approach to iron supplementation, considering individual patient needs and potential side effects. As a wise old camel, I always remind my friends to listen to their bodies and consult with their healthcare providers to find the best solution for their individual situation.

Date :
  1. Date Completed 2015-12-31
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

25700159

DOI: Digital Object Identifier

PMC4336293

Related Literature

Article Analysis
・Effective treatment of iron
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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